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Correlations between serum levels of 25-hydroxyvitamin D and carotid atherosclerosis in patients with type 2 diabetes in Shanghai.
Ann Endocrinol (Paris) 2014; 75(4):206-12AE

Abstract

OBJECTIVE

To explore the potential association between the serum levels of 25-hydroxyvitamin D [25(OH)D] and carotid atherosclerosis in patients with type 2 diabetes.

MATERIAL AND METHODS

Three hundred and fifty patients with type 2 diabetes were enrolled in this study in Shanghai, China. B-mode ultrasound was used to detect carotid plaques as indicators of atherosclerosis and measure carotid artery intima-media wall thickness (C-IMT) at two sites of carotid artery. Subjects were divided into group A (patients with carotid plaques) and group B (patients without carotid plaques) and be assessed clinically. Serum levels of 25(OH)D and other clinical parameters were measured. Multivariate logistic regression was performed to find predictors of carotid atherosclerosis in the entire group.

RESULTS

The levels of serum 25(OH)D were lower in group A than in group B[19.60 (13.30-25.73) vs 23.19 (18.10-30.06)ng/ml, P<0.001]. The C-IMT levels [(1.00±0.17 vs 0.88±0.20)mm, Ptrend<0.001] and proportion of people with carotid plaques(44/88 vs 20/87, Ptrend<0.001) in the lowest quartile of 25(OH)D were higher than in the highest quartile. Vitamin D concentrations were inversely associated with HbA1c in women(r=-0.194, P=0.006), and C-IMT in men(r=-0.409, P<0.001). Logistic regression analysis showed age, male sex, current smoke, history of hypertension, SBP, LDL-C and lg[25(OH)D] (OR: 0.924, 95%CI: 0.893-0.955, P<0.001) were independently associated with the presence of carotid plaques in T2DM.

CONCLUSIONS

Serum vitamin D level is significantly and independently associated with carotid atherosclerosis in patients with T2DM in Shanghai, China.

Authors+Show Affiliations

Department of endocrinology, Pudong New Area People's Hospital, 490, South Chuan Huan Road, Shanghai, China.Department of endocrinology, Pudong New Area People's Hospital, 490, South Chuan Huan Road, Shanghai, China. Electronic address: jiangxz3338@126.com.Department of ultrasonography, Shanghai Pudong New Area People's Hospital, Shanghai, China.Department of endocrinology, Pudong New Area People's Hospital, 490, South Chuan Huan Road, Shanghai, China.Department of endocrinology, Pudong New Area People's Hospital, 490, South Chuan Huan Road, Shanghai, China.Department of endocrinology, Pudong New Area People's Hospital, 490, South Chuan Huan Road, Shanghai, China.Department of endocrinology, Pudong New Area People's Hospital, 490, South Chuan Huan Road, Shanghai, China.Department of endocrinology, Pudong New Area People's Hospital, 490, South Chuan Huan Road, Shanghai, China.Department of endocrinology, Pudong New Area People's Hospital, 490, South Chuan Huan Road, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25168108

Citation

Chen, Rui-hua, et al. "Correlations Between Serum Levels of 25-hydroxyvitamin D and Carotid Atherosclerosis in Patients With Type 2 Diabetes in Shanghai." Annales D'endocrinologie, vol. 75, no. 4, 2014, pp. 206-12.
Chen RH, Jiang XZ, Jiang Q, et al. Correlations between serum levels of 25-hydroxyvitamin D and carotid atherosclerosis in patients with type 2 diabetes in Shanghai. Ann Endocrinol (Paris). 2014;75(4):206-12.
Chen, R. H., Jiang, X. Z., Jiang, Q., Gu, Z., Gu, P. L., Zhou, B., ... Zou, Y. F. (2014). Correlations between serum levels of 25-hydroxyvitamin D and carotid atherosclerosis in patients with type 2 diabetes in Shanghai. Annales D'endocrinologie, 75(4), pp. 206-12. doi:10.1016/j.ando.2014.07.113.
Chen RH, et al. Correlations Between Serum Levels of 25-hydroxyvitamin D and Carotid Atherosclerosis in Patients With Type 2 Diabetes in Shanghai. Ann Endocrinol (Paris). 2014;75(4):206-12. PubMed PMID: 25168108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlations between serum levels of 25-hydroxyvitamin D and carotid atherosclerosis in patients with type 2 diabetes in Shanghai. AU - Chen,Rui-hua, AU - Jiang,Xiao-zhen, AU - Jiang,Quan, AU - Gu,Zhe, AU - Gu,Pei-li, AU - Zhou,Bin, AU - Zhu,Zhen-hong, AU - Xu,Lin-yan, AU - Zou,Yu-feng, Y1 - 2014/08/26/ PY - 2013/08/01/received PY - 2014/03/16/revised PY - 2014/07/04/accepted PY - 2014/8/30/entrez PY - 2014/8/30/pubmed PY - 2015/5/15/medline KW - 25-hydroxyvitamin D KW - 25-hydroxyvitamine D KW - Atherosclerosis KW - Athérosclérose subclinique KW - Carotid intima-media thickness KW - Diabetes mellitus type 2 KW - Diabète de type 2 KW - Épaisseur intima-média carotidienne SP - 206 EP - 12 JF - Annales d'endocrinologie JO - Ann. Endocrinol. (Paris) VL - 75 IS - 4 N2 - OBJECTIVE: To explore the potential association between the serum levels of 25-hydroxyvitamin D [25(OH)D] and carotid atherosclerosis in patients with type 2 diabetes. MATERIAL AND METHODS: Three hundred and fifty patients with type 2 diabetes were enrolled in this study in Shanghai, China. B-mode ultrasound was used to detect carotid plaques as indicators of atherosclerosis and measure carotid artery intima-media wall thickness (C-IMT) at two sites of carotid artery. Subjects were divided into group A (patients with carotid plaques) and group B (patients without carotid plaques) and be assessed clinically. Serum levels of 25(OH)D and other clinical parameters were measured. Multivariate logistic regression was performed to find predictors of carotid atherosclerosis in the entire group. RESULTS: The levels of serum 25(OH)D were lower in group A than in group B[19.60 (13.30-25.73) vs 23.19 (18.10-30.06)ng/ml, P<0.001]. The C-IMT levels [(1.00±0.17 vs 0.88±0.20)mm, Ptrend<0.001] and proportion of people with carotid plaques(44/88 vs 20/87, Ptrend<0.001) in the lowest quartile of 25(OH)D were higher than in the highest quartile. Vitamin D concentrations were inversely associated with HbA1c in women(r=-0.194, P=0.006), and C-IMT in men(r=-0.409, P<0.001). Logistic regression analysis showed age, male sex, current smoke, history of hypertension, SBP, LDL-C and lg[25(OH)D] (OR: 0.924, 95%CI: 0.893-0.955, P<0.001) were independently associated with the presence of carotid plaques in T2DM. CONCLUSIONS: Serum vitamin D level is significantly and independently associated with carotid atherosclerosis in patients with T2DM in Shanghai, China. SN - 2213-3941 UR - https://www.unboundmedicine.com/medline/citation/25168108/Correlations_between_serum_levels_of_25_hydroxyvitamin_D_and_carotid_atherosclerosis_in_patients_with_type_2_diabetes_in_Shanghai_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-4266(14)00204-2 DB - PRIME DP - Unbound Medicine ER -