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Alcohol drinking and the risk of colorectal cancer death: a meta-analysis.
Eur J Cancer Prev 2014; 23(6):532-9EJ

Abstract

A causal link between alcohol consumption and colorectal cancer (CRC) was established only recently by the International Agency for Research on Cancer. However, the quantitative association between alcohol drinking and CRC mortality is still an open question. We performed a systemic review and meta-analysis on epidemiological studies to quantify the risk for CRC mortality at different levels of alcohol consumption. A literature search was carried out in PubMed and Web of Science to identify all relevant studies published from January 1966 to June 2013. The pooled relative risk (RR) and the corresponding 95% confidence interval (CI) were estimated by categorical meta-analysis. A dose-risk relation was also analyzed. Nine cohort studies exploring the association between CRC mortality and alcohol drinking were identified. Compared with non/occasional drinkers, the pooled RR was 1.03 (95% CI, 0.93-1.15) for any, 0.97 (95% CI, 0.86-1.10) for light (≤12.5 g/day of ethanol), 1.04 (95% CI, 0.94-1.16) for moderate (12.6-49.9 g/day of ethanol), and 1.21 (1.01-1.46) for heavy drinkers (≥50 g/day of ethanol). For heavy drinkers, the pooled estimate was apparently higher for men (RR=1.28; 95% CI, 1.13-1.46) than for women (RR=0.79; 95% CI, 0.40-1.54; P(heterogeneity)=0.007). The dose-response analysis showed a J-shaped relationship between alcohol consumption and CRC mortality. The present meta-analysis provides the evidence for an association between heavy alcohol drinking (≥50 g/day of ethanol) and CRC mortality.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25170915

Citation

Cai, Shaofang, et al. "Alcohol Drinking and the Risk of Colorectal Cancer Death: a Meta-analysis." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 23, no. 6, 2014, pp. 532-9.
Cai S, Li Y, Ding Y, et al. Alcohol drinking and the risk of colorectal cancer death: a meta-analysis. Eur J Cancer Prev. 2014;23(6):532-9.
Cai, S., Li, Y., Ding, Y., Chen, K., & Jin, M. (2014). Alcohol drinking and the risk of colorectal cancer death: a meta-analysis. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 23(6), pp. 532-9. doi:10.1097/CEJ.0000000000000076.
Cai S, et al. Alcohol Drinking and the Risk of Colorectal Cancer Death: a Meta-analysis. Eur J Cancer Prev. 2014;23(6):532-9. PubMed PMID: 25170915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking and the risk of colorectal cancer death: a meta-analysis. AU - Cai,Shaofang, AU - Li,Yingjun, AU - Ding,Ye, AU - Chen,Kun, AU - Jin,Mingjuan, PY - 2014/8/30/entrez PY - 2014/8/30/pubmed PY - 2015/6/9/medline SP - 532 EP - 9 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 23 IS - 6 N2 - A causal link between alcohol consumption and colorectal cancer (CRC) was established only recently by the International Agency for Research on Cancer. However, the quantitative association between alcohol drinking and CRC mortality is still an open question. We performed a systemic review and meta-analysis on epidemiological studies to quantify the risk for CRC mortality at different levels of alcohol consumption. A literature search was carried out in PubMed and Web of Science to identify all relevant studies published from January 1966 to June 2013. The pooled relative risk (RR) and the corresponding 95% confidence interval (CI) were estimated by categorical meta-analysis. A dose-risk relation was also analyzed. Nine cohort studies exploring the association between CRC mortality and alcohol drinking were identified. Compared with non/occasional drinkers, the pooled RR was 1.03 (95% CI, 0.93-1.15) for any, 0.97 (95% CI, 0.86-1.10) for light (≤12.5 g/day of ethanol), 1.04 (95% CI, 0.94-1.16) for moderate (12.6-49.9 g/day of ethanol), and 1.21 (1.01-1.46) for heavy drinkers (≥50 g/day of ethanol). For heavy drinkers, the pooled estimate was apparently higher for men (RR=1.28; 95% CI, 1.13-1.46) than for women (RR=0.79; 95% CI, 0.40-1.54; P(heterogeneity)=0.007). The dose-response analysis showed a J-shaped relationship between alcohol consumption and CRC mortality. The present meta-analysis provides the evidence for an association between heavy alcohol drinking (≥50 g/day of ethanol) and CRC mortality. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/25170915/Alcohol_drinking_and_the_risk_of_colorectal_cancer_death:_a_meta_analysis_ L2 - http://Insights.ovid.com/pubmed?pmid=25170915 DB - PRIME DP - Unbound Medicine ER -