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Angiogenesis contributes to the neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats.
Int J Neurosci. 2015; 125(8):625-34.IJ

Abstract

Ischemic stroke is one of the leading causes of mortality and disability worldwide. Previous studies have indicated that hyperbaric oxygen preconditioning (HBO-PC) can induce neuroprotection against focal cerebral ischemia. However, the underlying mechanisms are still not fully understood, and the optimal regimen for preconditioning must be confirmed. In the present study, we designed eight preconditioning regimens and compared their neuroprotective effects. Hyperbaric oxygen preconditioning every other day for there sessions exhibited the best neuroprotective effect; the infarct volume was reduced by almost 50% at 48 h after middle cerebral artery occlusion. We also found that HBO-PC significantly increased the microvessel density and the CD31-positive cells in the penumbra at 72 h after stroke. These results indicate that angiogenesis is involved in the neuroprotection induced by HBO-PC. Moreover, we explored the roles of HIF-1α and angiogenic factors in the angiogenesis process induced by HBO-PC. The results from western blotting demonstrated that protein expression of Ang-2 in the HBO-PC group was significantly increased. In conclusion, HBO-PC reduced brain injury and improved neurological function after focal cerebral ischemia, as partly mediated by the increased microvessel density in the penumbra, and this effect may result from the upregulation of Ang-2.

Authors+Show Affiliations

1Department of Neurology, Shanghai No. 5 Hospital, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25171223

Citation

Duan, Shanshan, et al. "Angiogenesis Contributes to the Neuroprotection Induced By Hyperbaric Oxygen Preconditioning Against Focal Cerebral Ischemia in Rats." The International Journal of Neuroscience, vol. 125, no. 8, 2015, pp. 625-34.
Duan S, Shao G, Yu L, et al. Angiogenesis contributes to the neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. Int J Neurosci. 2015;125(8):625-34.
Duan, S., Shao, G., Yu, L., & Ren, C. (2015). Angiogenesis contributes to the neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. The International Journal of Neuroscience, 125(8), 625-34. https://doi.org/10.3109/00207454.2014.956101
Duan S, et al. Angiogenesis Contributes to the Neuroprotection Induced By Hyperbaric Oxygen Preconditioning Against Focal Cerebral Ischemia in Rats. Int J Neurosci. 2015;125(8):625-34. PubMed PMID: 25171223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiogenesis contributes to the neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. AU - Duan,Shanshan, AU - Shao,Guiqiang, AU - Yu,Ling, AU - Ren,Chuancheng, Y1 - 2014/09/17/ PY - 2014/8/30/entrez PY - 2014/8/30/pubmed PY - 2016/5/7/medline KW - angiogenesis KW - angiopoietin-2 KW - hyperbaric oxygen preconditioning KW - neuroprotection KW - stroke SP - 625 EP - 34 JF - The International journal of neuroscience JO - Int. J. Neurosci. VL - 125 IS - 8 N2 - Ischemic stroke is one of the leading causes of mortality and disability worldwide. Previous studies have indicated that hyperbaric oxygen preconditioning (HBO-PC) can induce neuroprotection against focal cerebral ischemia. However, the underlying mechanisms are still not fully understood, and the optimal regimen for preconditioning must be confirmed. In the present study, we designed eight preconditioning regimens and compared their neuroprotective effects. Hyperbaric oxygen preconditioning every other day for there sessions exhibited the best neuroprotective effect; the infarct volume was reduced by almost 50% at 48 h after middle cerebral artery occlusion. We also found that HBO-PC significantly increased the microvessel density and the CD31-positive cells in the penumbra at 72 h after stroke. These results indicate that angiogenesis is involved in the neuroprotection induced by HBO-PC. Moreover, we explored the roles of HIF-1α and angiogenic factors in the angiogenesis process induced by HBO-PC. The results from western blotting demonstrated that protein expression of Ang-2 in the HBO-PC group was significantly increased. In conclusion, HBO-PC reduced brain injury and improved neurological function after focal cerebral ischemia, as partly mediated by the increased microvessel density in the penumbra, and this effect may result from the upregulation of Ang-2. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/25171223/Angiogenesis_contributes_to_the_neuroprotection_induced_by_hyperbaric_oxygen_preconditioning_against_focal_cerebral_ischemia_in_rats_ L2 - http://www.tandfonline.com/doi/full/10.3109/00207454.2014.956101 DB - PRIME DP - Unbound Medicine ER -