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Determination of urinary levels of Bisphenol A in a Turkish population.
Environ Monit Assess. 2014 Dec; 186(12):8443-52.EM

Abstract

Bisphenol A (BPA) is one of the environmental endocrine disrupting chemicals that is widely used in common consumer products. The aim of this study was to report the total urinary BPA concentrations (free plus conjugated) in 200 urine samples (children: 57; male: 74; female: 69) obtained from residents of a Mediterranean city, Mersin. Analyses were performed by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and for assessing environmental exposure to free BPA and its major metabolite bisphenol A glucuronide (BPAG) in human urine were determinated. Our results indicated that the free BPA and BPAG concentrations were in the range of 0.06-0.99 μg/g creatinine and 0.24-615 μg/g creatinine, respectively. No statistically significant difference obtained in BPA concentrations between genders (male and female) or domicile of residence (rural and urban) (p > 0.05). In our study, the mean level of detected free BPA was 0.46 μg/g creatinine in the urban area and 0.37 μg/g creatinine in the rural area. The average amount of BPAG was 60.56 μg/g creatinine in the urban area and 30.28 μg/g creatinine in the rural area. The data demonstrate that determined amount of total BPA in the present study is lower than the results of similar studies conducted in developed countries. There is no data about the levels of BPA in humans and environment in Turkey. Because of this reason, present study is very important since it is the first study in Turkey which determined the concentrations of free BPA and total BPA in human.

Authors+Show Affiliations

Faculty of Pharmacy, Department of Toxicology, Mersin University, 33169, Mersin, Turkey, diakunal@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25171897

Citation

Battal, Dilek, et al. "Determination of Urinary Levels of Bisphenol a in a Turkish Population." Environmental Monitoring and Assessment, vol. 186, no. 12, 2014, pp. 8443-52.
Battal D, Cok I, Unlusayin I, et al. Determination of urinary levels of Bisphenol A in a Turkish population. Environ Monit Assess. 2014;186(12):8443-52.
Battal, D., Cok, I., Unlusayin, I., Aktas, A., & Tunctan, B. (2014). Determination of urinary levels of Bisphenol A in a Turkish population. Environmental Monitoring and Assessment, 186(12), 8443-52. https://doi.org/10.1007/s10661-014-4015-z
Battal D, et al. Determination of Urinary Levels of Bisphenol a in a Turkish Population. Environ Monit Assess. 2014;186(12):8443-52. PubMed PMID: 25171897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of urinary levels of Bisphenol A in a Turkish population. AU - Battal,Dilek, AU - Cok,Ismet, AU - Unlusayin,Irfan, AU - Aktas,Ayca, AU - Tunctan,Bahar, Y1 - 2014/08/30/ PY - 2014/07/05/received PY - 2014/08/15/accepted PY - 2014/8/31/entrez PY - 2014/8/31/pubmed PY - 2015/5/2/medline SP - 8443 EP - 52 JF - Environmental monitoring and assessment JO - Environ Monit Assess VL - 186 IS - 12 N2 - Bisphenol A (BPA) is one of the environmental endocrine disrupting chemicals that is widely used in common consumer products. The aim of this study was to report the total urinary BPA concentrations (free plus conjugated) in 200 urine samples (children: 57; male: 74; female: 69) obtained from residents of a Mediterranean city, Mersin. Analyses were performed by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and for assessing environmental exposure to free BPA and its major metabolite bisphenol A glucuronide (BPAG) in human urine were determinated. Our results indicated that the free BPA and BPAG concentrations were in the range of 0.06-0.99 μg/g creatinine and 0.24-615 μg/g creatinine, respectively. No statistically significant difference obtained in BPA concentrations between genders (male and female) or domicile of residence (rural and urban) (p > 0.05). In our study, the mean level of detected free BPA was 0.46 μg/g creatinine in the urban area and 0.37 μg/g creatinine in the rural area. The average amount of BPAG was 60.56 μg/g creatinine in the urban area and 30.28 μg/g creatinine in the rural area. The data demonstrate that determined amount of total BPA in the present study is lower than the results of similar studies conducted in developed countries. There is no data about the levels of BPA in humans and environment in Turkey. Because of this reason, present study is very important since it is the first study in Turkey which determined the concentrations of free BPA and total BPA in human. SN - 1573-2959 UR - https://www.unboundmedicine.com/medline/citation/25171897/Determination_of_urinary_levels_of_Bisphenol_A_in_a_Turkish_population_ L2 - https://doi.org/10.1007/s10661-014-4015-z DB - PRIME DP - Unbound Medicine ER -