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The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial.
Nutr Metab Cardiovasc Dis 2015; 25(1):46-51NM

Abstract

BACKGROUND AND AIMS

Despite strong mechanistic data, and promising results from in vitro and animal studies, the ability of probiotic bacteria to improve blood pressure and serum lipid concentrations in humans remains uncertain. The aim of this study was to determine the effect of Lactobacillus acidophilus La5 and Bifidobacterium animalis subsp lactis Bb12, provided in either yoghurt or capsule form, on home blood pressure and serum lipid profile.

METHODS AND RESULTS

Following a 3-week washout period, 156 overweight men and women over 55 y were randomized to a 6-week double-blinded, factorial, parallel study. The four intervention groups were: A) probiotic yoghurt plus probiotic capsules; B) probiotic yoghurt plus placebo capsules; C) control milk plus probiotic capsules; and D) control milk plus placebo capsules. Each probiotic test article provided a minimum L. acidophilus La5 and B. animalis subsp. lactis Bb12 dose of 3.0 × 10⁹ CFU/d. Home blood pressure monitoring, consisting of 7-day bi-daily repeat measurements, were collected at baseline and week 6. Fasting total cholesterol, low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), and serum triglyceride were performed at baseline and week 6. When compared to control milk, probiotic yoghurt did not significantly alter blood pressure, heart rate or serum lipid concentrations (P > 0.05). Similarly, when compared to placebo capsules, supplementation with probiotic capsules did not alter blood pressure or concentrations of total cholesterol LDLC, HDLC, or triglycerides (P > 0.05).

CONCLUSIONS

The probiotic strains L. acidophilus La5 and B. animalis subsp. lactis Bb12 did not improve cardiovascular risk factors.

Authors+Show Affiliations

University of Western Australia, School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Australia; Sir Charles Gairdner Hospital, Department of Endocrinology and Diabetes, Australia. Electronic address: kerry.ivey@gmail.com.University of Western Australia, School of Medicine and Pharmacology, Royal Perth Hospital, Australia.Curtin University, School of Public Health, Australia.Sir Charles Gairdner Hospital, Department of Cardiovascular Medicine, Australia.University of Western Australia, School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Australia; Sir Charles Gairdner Hospital, Department of Endocrinology and Diabetes, Australia.University of Western Australia, School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Australia; Sir Charles Gairdner Hospital, Department of Endocrinology and Diabetes, Australia.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25171898

Citation

Ivey, K L., et al. "The Effect of Yoghurt and Its Probiotics On Blood Pressure and Serum Lipid Profile; a Randomised Controlled Trial." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 25, no. 1, 2015, pp. 46-51.
Ivey KL, Hodgson JM, Kerr DA, et al. The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial. Nutr Metab Cardiovasc Dis. 2015;25(1):46-51.
Ivey, K. L., Hodgson, J. M., Kerr, D. A., Thompson, P. L., Stojceski, B., & Prince, R. L. (2015). The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 25(1), pp. 46-51. doi:10.1016/j.numecd.2014.07.012.
Ivey KL, et al. The Effect of Yoghurt and Its Probiotics On Blood Pressure and Serum Lipid Profile; a Randomised Controlled Trial. Nutr Metab Cardiovasc Dis. 2015;25(1):46-51. PubMed PMID: 25171898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial. AU - Ivey,K L, AU - Hodgson,J M, AU - Kerr,D A, AU - Thompson,P L, AU - Stojceski,B, AU - Prince,R L, Y1 - 2014/08/01/ PY - 2014/03/12/received PY - 2014/07/22/revised PY - 2014/07/22/accepted PY - 2014/8/31/entrez PY - 2014/8/31/pubmed PY - 2015/9/17/medline KW - Blood pressure KW - Cholesterol KW - Dairy KW - Lipid KW - Probiotics KW - Yoghurt SP - 46 EP - 51 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 25 IS - 1 N2 - BACKGROUND AND AIMS: Despite strong mechanistic data, and promising results from in vitro and animal studies, the ability of probiotic bacteria to improve blood pressure and serum lipid concentrations in humans remains uncertain. The aim of this study was to determine the effect of Lactobacillus acidophilus La5 and Bifidobacterium animalis subsp lactis Bb12, provided in either yoghurt or capsule form, on home blood pressure and serum lipid profile. METHODS AND RESULTS: Following a 3-week washout period, 156 overweight men and women over 55 y were randomized to a 6-week double-blinded, factorial, parallel study. The four intervention groups were: A) probiotic yoghurt plus probiotic capsules; B) probiotic yoghurt plus placebo capsules; C) control milk plus probiotic capsules; and D) control milk plus placebo capsules. Each probiotic test article provided a minimum L. acidophilus La5 and B. animalis subsp. lactis Bb12 dose of 3.0 × 10⁹ CFU/d. Home blood pressure monitoring, consisting of 7-day bi-daily repeat measurements, were collected at baseline and week 6. Fasting total cholesterol, low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), and serum triglyceride were performed at baseline and week 6. When compared to control milk, probiotic yoghurt did not significantly alter blood pressure, heart rate or serum lipid concentrations (P > 0.05). Similarly, when compared to placebo capsules, supplementation with probiotic capsules did not alter blood pressure or concentrations of total cholesterol LDLC, HDLC, or triglycerides (P > 0.05). CONCLUSIONS: The probiotic strains L. acidophilus La5 and B. animalis subsp. lactis Bb12 did not improve cardiovascular risk factors. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/25171898/The_effect_of_yoghurt_and_its_probiotics_on_blood_pressure_and_serum_lipid_profile L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(14)00255-5 DB - PRIME DP - Unbound Medicine ER -