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Morphologic variability of nonsyndromic operated patients affected by cleft lip and palate: a geometric morphometric study.
Am J Orthod Dentofacial Orthop. 2014 Sep; 146(3):346-54.AJ

Abstract

INTRODUCTION

In this study, we compared patterns of morphologic variations of the craniofacial skeleton between patients affected by clefts who were operated on and unaffected subjects, aiming to discuss possible morpho-functional consequences of treatment in craniofacial development.

METHODS

The lateral cephalograms of 76 subjects, comprising patients with operated unilateral cleft lip and palate (OpC) and a group matched for sex and age without cleft, were used. Thirteen landmarks were used as variables in geometric morphometric tests quantifying and describing overall shape variation, differences between group means, allometry, and upper-lower face covariation.

RESULTS

The OpC group showed broader shape variations including noncleft group characteristics, but mainly a retrognathic maxilla, a vertically elongated face, a more open mandibular angle, and a more closed basicranial angle. Group means differed mainly in the maxillomandibular relationships. Allometry differed between groups, with the smallest OpC patients showing the most altered morphology. Upper and lower face covariation was stronger in the OpC group, showing mainly vertical changes in the anterior face.

CONCLUSIONS

Operated patients affected by clefts achieve a broad range of morphologies; the most altered were found in those with skeletal Class III and small size. Furthermore, their strongest upper and lower face shape covariation suggests that a harmonic dental occlusion could be a key factor in achieving "normal" craniofacial morphology.

Authors+Show Affiliations

Researcher, Centre for Anatomical and Human Sciences, Hull York Medical School, Heslington, York, United Kingdom; lecturer, Facultad de Odontología, Universidad de Chile, Independencia, Región Metropolitana, Chile.Professor, Facultad de Odontología, Universidad de Chile, Independencia, Región Metropolitana, Chile.Lecturer, Facultad de Odontología, Universidad de Chile, Independencia, Región Metropolitana, Chile; orthodontist, Servicio de Cirugía Máxilo Facial, Hospital San Borja Arriarán, Santiago, Región Metropolitana, Chile.Associate professor, Centro de Análisis Cuantitativo en Antropología Dental, Facultad de Odontología, Universidad de Chile, Independencia, Región Metropolitana, Chile; associate professor, Facultad de Ciencias Sociales, Universidad de Chile, Ñuñoa, Región Metropolitana, Chile. Electronic address: gmanriqu@med.uchile.cl.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25172257

Citation

Toro-Ibacache, Viviana, et al. "Morphologic Variability of Nonsyndromic Operated Patients Affected By Cleft Lip and Palate: a Geometric Morphometric Study." American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics, vol. 146, no. 3, 2014, pp. 346-54.
Toro-Ibacache V, Cortés Araya J, Díaz Muñoz A, et al. Morphologic variability of nonsyndromic operated patients affected by cleft lip and palate: a geometric morphometric study. Am J Orthod Dentofacial Orthop. 2014;146(3):346-54.
Toro-Ibacache, V., Cortés Araya, J., Díaz Muñoz, A., & Manríquez Soto, G. (2014). Morphologic variability of nonsyndromic operated patients affected by cleft lip and palate: a geometric morphometric study. American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics, 146(3), 346-54. https://doi.org/10.1016/j.ajodo.2014.06.002
Toro-Ibacache V, et al. Morphologic Variability of Nonsyndromic Operated Patients Affected By Cleft Lip and Palate: a Geometric Morphometric Study. Am J Orthod Dentofacial Orthop. 2014;146(3):346-54. PubMed PMID: 25172257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphologic variability of nonsyndromic operated patients affected by cleft lip and palate: a geometric morphometric study. AU - Toro-Ibacache,Viviana, AU - Cortés Araya,Juan, AU - Díaz Muñoz,Alejandro, AU - Manríquez Soto,Germán, PY - 2014/02/01/received PY - 2014/06/01/revised PY - 2014/06/01/accepted PY - 2014/8/31/entrez PY - 2014/8/31/pubmed PY - 2014/10/24/medline SP - 346 EP - 54 JF - American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics JO - Am J Orthod Dentofacial Orthop VL - 146 IS - 3 N2 - INTRODUCTION: In this study, we compared patterns of morphologic variations of the craniofacial skeleton between patients affected by clefts who were operated on and unaffected subjects, aiming to discuss possible morpho-functional consequences of treatment in craniofacial development. METHODS: The lateral cephalograms of 76 subjects, comprising patients with operated unilateral cleft lip and palate (OpC) and a group matched for sex and age without cleft, were used. Thirteen landmarks were used as variables in geometric morphometric tests quantifying and describing overall shape variation, differences between group means, allometry, and upper-lower face covariation. RESULTS: The OpC group showed broader shape variations including noncleft group characteristics, but mainly a retrognathic maxilla, a vertically elongated face, a more open mandibular angle, and a more closed basicranial angle. Group means differed mainly in the maxillomandibular relationships. Allometry differed between groups, with the smallest OpC patients showing the most altered morphology. Upper and lower face covariation was stronger in the OpC group, showing mainly vertical changes in the anterior face. CONCLUSIONS: Operated patients affected by clefts achieve a broad range of morphologies; the most altered were found in those with skeletal Class III and small size. Furthermore, their strongest upper and lower face shape covariation suggests that a harmonic dental occlusion could be a key factor in achieving "normal" craniofacial morphology. SN - 1097-6752 UR - https://www.unboundmedicine.com/medline/citation/25172257/Morphologic_variability_of_nonsyndromic_operated_patients_affected_by_cleft_lip_and_palate:_a_geometric_morphometric_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-5406(14)00536-8 DB - PRIME DP - Unbound Medicine ER -