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Single dosage of doxycycline for prophylaxis against leptospiral infection and leptospirosis during urban flooding in southern Thailand: a non-randomized controlled trial.
J Infect Chemother. 2014 Nov; 20(11):709-15.JI

Abstract

This study was conducted to investigate the protective efficacy of a single dosage of 200 mg doxycycline against leptospiral infection and leptospirosis and associated risk factors among residents exposed to flooding in southern Thailand. Of 641 participants, 600 received doxycycline while 41 did not. Twenty two participants were infected with Leptospira and six developed leptospirosis. Having a laceration wound was significantly associated with leptospiral infection (odds ratio [OR] = 37.20; P < 0.001) and leptospirosis (OR = 18.24; P = 0.003) whereas exposure to flood more than 3 h per day was associated with only leptospiral infection (OR = 3.70; P = 0.038). Seventeen participants who received doxycycline and five who did not, were infected with Leptospira, resulting a protective efficacy of 76.8% (95% confidence interval [CI] = 34.3%-92.0%). Four who received doxycycline and two who did not, developed leptospirosis, resulting a protective efficacy of 86.3% (CI = -9.8%-98.2%). Among the participants with laceration wound, the protective efficacy for leptospiral infection was 92.0% (CI = 81.2%-96.6%) and for leptospirosis was 95.6% (CI = 78.2%-99.3%). Among the participants exposed to flood water less than or equal to 3 h per day, the protective efficacy for leptospiral infection was 89.2% (95% CI 63.6%-96.67%). A single dosage of 200 mg doxycycline for prophylaxis might be effective for preventing leptospirosis among flood victims with laceration wound after recent flood exposure.

Authors+Show Affiliations

Division of Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. Electronic address: sarunyouchusri@hotmail.com.Epidemiology Unit, Department of Community Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.Division of Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.Division of Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.Division of Serology, Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.Department of Pharmacy, Faculty of Pharmacy, Silapakorn University, Nakornpathom, Thailand.Department of Clinical Pharmacy, Faculty of Pharmacy, Prince of Songkla University, Songkhla, Thailand.Department of Clinical Pharmacy, Faculty of Pharmacy, Prince of Songkla University, Songkhla, Thailand.Department of Virology, Armed Forces Research Institute of Medial Sciences, Bangkok, Thailand.Department of Virology, Armed Forces Research Institute of Medial Sciences, Bangkok, Thailand.

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

25172777

Citation

Chusri, Sarunyou, et al. "Single Dosage of Doxycycline for Prophylaxis Against Leptospiral Infection and Leptospirosis During Urban Flooding in Southern Thailand: a Non-randomized Controlled Trial." Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, vol. 20, no. 11, 2014, pp. 709-15.
Chusri S, McNeil EB, Hortiwakul T, et al. Single dosage of doxycycline for prophylaxis against leptospiral infection and leptospirosis during urban flooding in southern Thailand: a non-randomized controlled trial. J Infect Chemother. 2014;20(11):709-15.
Chusri, S., McNeil, E. B., Hortiwakul, T., Charernmak, B., Sritrairatchai, S., Santimaleeworagun, W., Pattharachayakul, S., Suksanan, P., Thaisomboonsuk, B., & Jarman, R. G. (2014). Single dosage of doxycycline for prophylaxis against leptospiral infection and leptospirosis during urban flooding in southern Thailand: a non-randomized controlled trial. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 20(11), 709-15. https://doi.org/10.1016/j.jiac.2014.07.016
Chusri S, et al. Single Dosage of Doxycycline for Prophylaxis Against Leptospiral Infection and Leptospirosis During Urban Flooding in Southern Thailand: a Non-randomized Controlled Trial. J Infect Chemother. 2014;20(11):709-15. PubMed PMID: 25172777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single dosage of doxycycline for prophylaxis against leptospiral infection and leptospirosis during urban flooding in southern Thailand: a non-randomized controlled trial. AU - Chusri,Sarunyou, AU - McNeil,Edward B, AU - Hortiwakul,Thanaporn, AU - Charernmak,Boonsri, AU - Sritrairatchai,Somporn, AU - Santimaleeworagun,Wichai, AU - Pattharachayakul,Sutthiporn, AU - Suksanan,Paritasana, AU - Thaisomboonsuk,Butsaya, AU - Jarman,Richard G, Y1 - 2014/09/22/ PY - 2014/06/20/received PY - 2014/07/17/revised PY - 2014/07/22/accepted PY - 2014/8/31/entrez PY - 2014/8/31/pubmed PY - 2015/7/29/medline KW - Doxycycline KW - Flooding KW - Leptospirosis KW - Prophylaxis SP - 709 EP - 15 JF - Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy JO - J Infect Chemother VL - 20 IS - 11 N2 - This study was conducted to investigate the protective efficacy of a single dosage of 200 mg doxycycline against leptospiral infection and leptospirosis and associated risk factors among residents exposed to flooding in southern Thailand. Of 641 participants, 600 received doxycycline while 41 did not. Twenty two participants were infected with Leptospira and six developed leptospirosis. Having a laceration wound was significantly associated with leptospiral infection (odds ratio [OR] = 37.20; P < 0.001) and leptospirosis (OR = 18.24; P = 0.003) whereas exposure to flood more than 3 h per day was associated with only leptospiral infection (OR = 3.70; P = 0.038). Seventeen participants who received doxycycline and five who did not, were infected with Leptospira, resulting a protective efficacy of 76.8% (95% confidence interval [CI] = 34.3%-92.0%). Four who received doxycycline and two who did not, developed leptospirosis, resulting a protective efficacy of 86.3% (CI = -9.8%-98.2%). Among the participants with laceration wound, the protective efficacy for leptospiral infection was 92.0% (CI = 81.2%-96.6%) and for leptospirosis was 95.6% (CI = 78.2%-99.3%). Among the participants exposed to flood water less than or equal to 3 h per day, the protective efficacy for leptospiral infection was 89.2% (95% CI 63.6%-96.67%). A single dosage of 200 mg doxycycline for prophylaxis might be effective for preventing leptospirosis among flood victims with laceration wound after recent flood exposure. SN - 1437-7780 UR - https://www.unboundmedicine.com/medline/citation/25172777/Single_dosage_of_doxycycline_for_prophylaxis_against_leptospiral_infection_and_leptospirosis_during_urban_flooding_in_southern_Thailand:_a_non_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1341-321X(14)00257-8 DB - PRIME DP - Unbound Medicine ER -