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The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix.
Phytomedicine. 2014 Sep 25; 21(11):1318-24.P

Abstract

Angelica Sinensis Radix (roots of Angelica sinensis; ASR) is a popular herbal supplement in China for promoting blood circulation. Today, sulfur-fumigation is commonly used to treat ASR as a means of pest control; however, the studies of sulfur-fumigation on the safety and efficacy of ASR are very limited. Here, we elucidated the destructive roles of sulfur-fumigation on ASR by chemical and biological assessments. After sulfur-fumigation, the chemicals in ASR were significantly lost. The biological activities of anti-platelet aggregation, induction of NO production and estrogenic properties were compared between the water extracts of non-fumigated and sulfur-fumigated ASR. In all cases, the sulfur-fumigation significantly reduced the biological properties of ASR. In addition, application of water extract deriving from sulfur-fumigated ASR showed toxicity to cultured MCF-7 cells. In order to ensure the safety and to achieve the best therapeutic effect, it is recommended that sulfur-fumigation is an unacceptable approach for processing herbal materials.

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Publisher Full Text (DOI)

Authors+Show Affiliations

School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China.

Department of Biology, Hanshan Normal University, Chaozhou, Guangdong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China.

School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China. Electronic address: botsim@ust.hk.

MeSH

Angelica sinensisAnimalsDrugs, Chinese HerbalFumigationHuman Umbilical Vein Endothelial CellsHumansMCF-7 CellsNitric OxidePlant ExtractsPlant RootsPlatelet AggregationRabbitsSulfur

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25172796

Citation

Zhan, Janis Ya-Xian, et al. "The Sulfur-fumigation Reduces Chemical Composition and Biological Properties of Angelicae Sinensis Radix." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 21, no. 11, 2014, pp. 1318-24.

Zhan JY, Yao P, Bi CW, et al. The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix. Phytomedicine. 2014;21(11):1318-24.

Zhan, J. Y., Yao, P., Bi, C. W., Zheng, K. Y., Zhang, W. L., Chen, J. P., Dong, T. T., Su, Z. R., & Tsim, K. W. (2014). The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 21(11), 1318-24. https://doi.org/10.1016/j.phymed.2014.07.002

Zhan JY, et al. The Sulfur-fumigation Reduces Chemical Composition and Biological Properties of Angelicae Sinensis Radix. Phytomedicine. 2014 Sep 25;21(11):1318-24. PubMed PMID: 25172796.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix. AU - Zhan,Janis Ya-Xian, AU - Yao,Ping, AU - Bi,Cathy Wen-Chuan, AU - Zheng,Ken Yu-Zhong, AU - Zhang,Wendy Li, AU - Chen,Jian-Ping, AU - Dong,Tina Ting-Xia, AU - Su,Zi-Ren, AU - Tsim,Karl Wah-Keung, Y1 - 2014/07/31/ PY - 2014/03/19/received PY - 2014/05/27/revised PY - 2014/07/02/accepted PY - 2014/8/31/entrez PY - 2014/8/31/pubmed PY - 2015/3/31/medline KW - Angelica Sinensis Radix KW - Biological function KW - Chemical composition KW - Sulfur-fumigation SP - 1318 EP - 24 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 21 IS - 11 N2 - Angelica Sinensis Radix (roots of Angelica sinensis; ASR) is a popular herbal supplement in China for promoting blood circulation. Today, sulfur-fumigation is commonly used to treat ASR as a means of pest control; however, the studies of sulfur-fumigation on the safety and efficacy of ASR are very limited. Here, we elucidated the destructive roles of sulfur-fumigation on ASR by chemical and biological assessments. After sulfur-fumigation, the chemicals in ASR were significantly lost. The biological activities of anti-platelet aggregation, induction of NO production and estrogenic properties were compared between the water extracts of non-fumigated and sulfur-fumigated ASR. In all cases, the sulfur-fumigation significantly reduced the biological properties of ASR. In addition, application of water extract deriving from sulfur-fumigated ASR showed toxicity to cultured MCF-7 cells. In order to ensure the safety and to achieve the best therapeutic effect, it is recommended that sulfur-fumigation is an unacceptable approach for processing herbal materials. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/25172796/The_sulfur_fumigation_reduces_chemical_composition_and_biological_properties_of_Angelicae_Sinensis_Radix_ DB - PRIME DP - Unbound Medicine ER -