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Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: a nested case-control study: plasma micronutrients and pancreatic cancer risk.
Int J Cancer 2015; 136(6):E665-76IJ

Abstract

Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (α- and β-carotene, lycopene, β-cryptoxanthin, canthaxanthin, zeaxanthin and lutein), α- and γ-tocopherol and retinol were measured by reverse phase high-performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma β-carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31-0.88, p for trend = 0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30-0.94, p for trend = 0.06) and α-tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39-0.99, p for trend = 0.08. For α- and β-carotene, lutein, sum of carotenoids and γ-tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of β-carotene, zeaxanthin and α-tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25175624

Citation

Jeurnink, Suzanne M., et al. "Plasma Carotenoids, Vitamin C, Retinol and Tocopherols Levels and Pancreatic Cancer Risk Within the European Prospective Investigation Into Cancer and Nutrition: a Nested Case-control Study: Plasma Micronutrients and Pancreatic Cancer Risk." International Journal of Cancer, vol. 136, no. 6, 2015, pp. E665-76.
Jeurnink SM, Ros MM, Leenders M, et al. Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: a nested case-control study: plasma micronutrients and pancreatic cancer risk. Int J Cancer. 2015;136(6):E665-76.
Jeurnink, S. M., Ros, M. M., Leenders, M., van Duijnhoven, F. J., Siersema, P. D., Jansen, E. H., ... Bueno-de-Mesquita, H. B. (2015). Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: a nested case-control study: plasma micronutrients and pancreatic cancer risk. International Journal of Cancer, 136(6), pp. E665-76. doi:10.1002/ijc.29175.
Jeurnink SM, et al. Plasma Carotenoids, Vitamin C, Retinol and Tocopherols Levels and Pancreatic Cancer Risk Within the European Prospective Investigation Into Cancer and Nutrition: a Nested Case-control Study: Plasma Micronutrients and Pancreatic Cancer Risk. Int J Cancer. 2015 Mar 15;136(6):E665-76. PubMed PMID: 25175624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: a nested case-control study: plasma micronutrients and pancreatic cancer risk. AU - Jeurnink,Suzanne M, AU - Ros,Martine M, AU - Leenders,Max, AU - van Duijnhoven,Franzel J B, AU - Siersema,Peter D, AU - Jansen,Eugene H J M, AU - van Gils,Carla H, AU - Bakker,Marije F, AU - Overvad,Kim, AU - Roswall,Nina, AU - Tjønneland,Anne, AU - Boutron-Ruault,Marie-Christine, AU - Racine,Antoine, AU - Cadeau,Claire, AU - Grote,Verena, AU - Kaaks,Rudolf, AU - Aleksandrova,Krasimira, AU - Boeing,Heiner, AU - Trichopoulou,Antonia, AU - Benetou,Vasiliki, AU - Valanou,Elisavet, AU - Palli,Domenico, AU - Krogh,Vittorio, AU - Vineis,Paolo, AU - Tumino,Rosario, AU - Mattiello,Amalia, AU - Weiderpass,Elisabete, AU - Skeie,Guri, AU - Castaño,José María Huerta, AU - Duell,Eric J, AU - Barricarte,Aurelio, AU - Molina-Montes,Esther, AU - Argüelles,Marcial, AU - Dorronsoro,Mire, AU - Johansen,Dorthe, AU - Lindkvist,Björn, AU - Sund,Malin, AU - Crowe,Francesca L, AU - Khaw,Kay-Tee, AU - Jenab,Mazda, AU - Fedirko,Veronika, AU - Riboli,E, AU - Bueno-de-Mesquita,H B, Y1 - 2014/09/17/ PY - 2014/01/27/received PY - 2014/06/19/revised PY - 2014/06/23/accepted PY - 2014/9/2/entrez PY - 2014/9/2/pubmed PY - 2015/4/23/medline KW - carotenoid KW - pancreatic cancer KW - retinol KW - tocopherol KW - vitamin C SP - E665 EP - 76 JF - International journal of cancer JO - Int. J. Cancer VL - 136 IS - 6 N2 - Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (α- and β-carotene, lycopene, β-cryptoxanthin, canthaxanthin, zeaxanthin and lutein), α- and γ-tocopherol and retinol were measured by reverse phase high-performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma β-carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31-0.88, p for trend = 0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30-0.94, p for trend = 0.06) and α-tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39-0.99, p for trend = 0.08. For α- and β-carotene, lutein, sum of carotenoids and γ-tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of β-carotene, zeaxanthin and α-tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/25175624/Plasma_carotenoids_vitamin_C_retinol_and_tocopherols_levels_and_pancreatic_cancer_risk_within_the_European_Prospective_Investigation_into_Cancer_and_Nutrition:_a_nested_case_control_study:_plasma_micronutrients_and_pancreatic_cancer_risk_ L2 - https://doi.org/10.1002/ijc.29175 DB - PRIME DP - Unbound Medicine ER -