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Comparison of adrenocortical steroidogenesis in women with post-adolescent severe acne and polycystic ovary syndrome.
J Eur Acad Dermatol Venereol. 2015 May; 29(5):875-80.JE

Abstract

BACKGROUND

Increased adrenocortical production appears to be associated with acne and hirsutism in acne and polycystic ovary syndrome (PCOS). However, the aetiological role of androgens in the pathogenesis of acne per se is far from being clear.

OBJECTIVE

We aimed to evaluate adrenocortical function in women with post-adolescent severe acne in comparison with patients with PCOS and healthy women.

METHODS

The study included 32 women with post-adolescent severe acne, 32 women with PCOS and 32 age and body mass index (BMI)-matched healthy controls (age 17-34 years, BMI: 20.8 ± 1.9 kg/m²). Women with acne did not have hirsutism or ovulatory dysfunction whereas all PCOS patients had androgen excess and ovulatory dysfunction. Measurements included basal testosterone (T), sex hormone-binding globulin (SHBG) and dehydroepiandrosterone sulphate (DHEAS) levels and serum 17-hydroxyprogesterone (17-OHP), androstenedione (A4), DHEA and cortisol levels in response to corticotropin (ACTH) stimulation.

RESULTS

T, free androgen index, DHEAS levels, basal and AUC (area under the curve) values for A4 were significantly higher in PCOS than women with acne and controls (P < 0.05 for all), whereas three groups did not differ for basal or AUC values of DHEA and cortisol. Women with PCOS and those with severe acne had significantly and similarly higher AUC values of 17-OHP compared to controls (P < 0.05).

CONCLUSION

Women with isolated post-adolescent severe acne do not have increased levels of adrenal androgens basally or in response to ACTH. However, these women have similar secretion pattern of 17-OHP with PCOS patients suggesting increased enzymatic activity in this pathway.

Authors+Show Affiliations

Department of Internal Medicine, Division of Endocrinology and Metabolism, Hacettepe University School of Medicine, Hacettepe, Ankara, 06100, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25176476

Citation

Cinar, N, et al. "Comparison of Adrenocortical Steroidogenesis in Women With Post-adolescent Severe Acne and Polycystic Ovary Syndrome." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 29, no. 5, 2015, pp. 875-80.
Cinar N, Cetinozman F, Aksoy DY, et al. Comparison of adrenocortical steroidogenesis in women with post-adolescent severe acne and polycystic ovary syndrome. J Eur Acad Dermatol Venereol. 2015;29(5):875-80.
Cinar, N., Cetinozman, F., Aksoy, D. Y., Elcin, G., & Yildiz, B. O. (2015). Comparison of adrenocortical steroidogenesis in women with post-adolescent severe acne and polycystic ovary syndrome. Journal of the European Academy of Dermatology and Venereology : JEADV, 29(5), 875-80. https://doi.org/10.1111/jdv.12696
Cinar N, et al. Comparison of Adrenocortical Steroidogenesis in Women With Post-adolescent Severe Acne and Polycystic Ovary Syndrome. J Eur Acad Dermatol Venereol. 2015;29(5):875-80. PubMed PMID: 25176476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of adrenocortical steroidogenesis in women with post-adolescent severe acne and polycystic ovary syndrome. AU - Cinar,N, AU - Cetinozman,F, AU - Aksoy,D Y, AU - Elcin,G, AU - Yildiz,B O, Y1 - 2014/08/29/ PY - 2014/05/15/received PY - 2014/07/17/accepted PY - 2014/9/2/entrez PY - 2014/9/2/pubmed PY - 2016/2/18/medline SP - 875 EP - 80 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 29 IS - 5 N2 - BACKGROUND: Increased adrenocortical production appears to be associated with acne and hirsutism in acne and polycystic ovary syndrome (PCOS). However, the aetiological role of androgens in the pathogenesis of acne per se is far from being clear. OBJECTIVE: We aimed to evaluate adrenocortical function in women with post-adolescent severe acne in comparison with patients with PCOS and healthy women. METHODS: The study included 32 women with post-adolescent severe acne, 32 women with PCOS and 32 age and body mass index (BMI)-matched healthy controls (age 17-34 years, BMI: 20.8 ± 1.9 kg/m²). Women with acne did not have hirsutism or ovulatory dysfunction whereas all PCOS patients had androgen excess and ovulatory dysfunction. Measurements included basal testosterone (T), sex hormone-binding globulin (SHBG) and dehydroepiandrosterone sulphate (DHEAS) levels and serum 17-hydroxyprogesterone (17-OHP), androstenedione (A4), DHEA and cortisol levels in response to corticotropin (ACTH) stimulation. RESULTS: T, free androgen index, DHEAS levels, basal and AUC (area under the curve) values for A4 were significantly higher in PCOS than women with acne and controls (P < 0.05 for all), whereas three groups did not differ for basal or AUC values of DHEA and cortisol. Women with PCOS and those with severe acne had significantly and similarly higher AUC values of 17-OHP compared to controls (P < 0.05). CONCLUSION: Women with isolated post-adolescent severe acne do not have increased levels of adrenal androgens basally or in response to ACTH. However, these women have similar secretion pattern of 17-OHP with PCOS patients suggesting increased enzymatic activity in this pathway. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/25176476/Comparison_of_adrenocortical_steroidogenesis_in_women_with_post_adolescent_severe_acne_and_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -