Tags

Type your tag names separated by a space and hit enter

Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012.
Virol J. 2014 Sep 01; 11:157.VJ

Abstract

BACKGROUND

Hand, foot and mouth disease (HFMD) is usually caused by Enterovirus 71(EV71), and Coxsackievirus A16 (CV-A16) in Guangzhou, the biggest city of South China. However, Coxsackievirus A6 (CV-A6) were observed increased dramatically from 2010-2012.

METHODS

In order to understand and to describe the epidemiologic and genetic characteristics of CV-A6, specimens of 5482 suspected HFMD cases were collected and examined by real-time fluorescence PCR. All samples positive for enteroviruses were analyzed by descriptive statistics. Phylogenetic analysis of CV-A6 based on the VP1 sequences was performed to investigate molecular and evolutionary characteristics.

RESULTS

Coxsackievirus A6 increased dramatically from 9.04% in 2010 to 23.21% in 2012 and became one of the main causative agents of HFMD in Guangzhou. CV-A6 attack rates were highest in one to two year olds (33.14%). Typical clinic symptoms of CV-A6 HFMD include fever (589/720, 81.81%), maculopopular rash and vesicular exanthema around the perioral area (408/720, 56.66%), intraoral (545/720, 75.69%), the buttock (395/720, 54.86%), the trunk (244/720, 33.89%), the knee (188/720, 26.11%), and the dorsal aspects of hands (437/720, 60.69%). Phylogenetic analysis showed the CV-A6 isolates in this study belonged to Cluster A1 and were similar to those found in Shanghai in 2011 and 2012 (JX495148, KC414735), Shenzhen in 2011 (JX473394), Japan in 2011 (AB649243, AB649246), France in 2010(HE572928), Thailand in 2012(JX556564) and Israel in 2012 and 2013(.KF991010, KF991012).

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableGuangzhou Center for Disease Control and Prevention, NO,1, Qide Road, Baiyun District, Guangzhou, Guangdong, 510440, China. wangming@gzcdc.org.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25178398

Citation

Di, Biao, et al. "Circulation of Coxsackievirus A6 in Hand-foot-mouth Disease in Guangzhou, 2010-2012." Virology Journal, vol. 11, 2014, p. 157.
Di B, Zhang Y, Xie H, et al. Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012. Virol J. 2014;11:157.
Di, B., Zhang, Y., Xie, H., Li, X., Chen, C., Ding, P., He, P., Wang, D., Geng, J., Luo, L., Bai, Z., Yang, Z., & Wang, M. (2014). Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012. Virology Journal, 11, 157. https://doi.org/10.1186/1743-422X-11-157
Di B, et al. Circulation of Coxsackievirus A6 in Hand-foot-mouth Disease in Guangzhou, 2010-2012. Virol J. 2014 Sep 1;11:157. PubMed PMID: 25178398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012. AU - Di,Biao, AU - Zhang,Ying, AU - Xie,Huaping, AU - Li,Xiaoquan, AU - Chen,Chun, AU - Ding,Peng, AU - He,Peng, AU - Wang,Dahu, AU - Geng,Jinmei, AU - Luo,Lei, AU - Bai,Zhijun, AU - Yang,Zhicong, AU - Wang,Ming, Y1 - 2014/09/01/ PY - 2014/03/19/received PY - 2014/08/08/accepted PY - 2014/9/3/entrez PY - 2014/9/3/pubmed PY - 2015/5/20/medline SP - 157 EP - 157 JF - Virology journal JO - Virol J VL - 11 N2 - BACKGROUND: Hand, foot and mouth disease (HFMD) is usually caused by Enterovirus 71(EV71), and Coxsackievirus A16 (CV-A16) in Guangzhou, the biggest city of South China. However, Coxsackievirus A6 (CV-A6) were observed increased dramatically from 2010-2012. METHODS: In order to understand and to describe the epidemiologic and genetic characteristics of CV-A6, specimens of 5482 suspected HFMD cases were collected and examined by real-time fluorescence PCR. All samples positive for enteroviruses were analyzed by descriptive statistics. Phylogenetic analysis of CV-A6 based on the VP1 sequences was performed to investigate molecular and evolutionary characteristics. RESULTS: Coxsackievirus A6 increased dramatically from 9.04% in 2010 to 23.21% in 2012 and became one of the main causative agents of HFMD in Guangzhou. CV-A6 attack rates were highest in one to two year olds (33.14%). Typical clinic symptoms of CV-A6 HFMD include fever (589/720, 81.81%), maculopopular rash and vesicular exanthema around the perioral area (408/720, 56.66%), intraoral (545/720, 75.69%), the buttock (395/720, 54.86%), the trunk (244/720, 33.89%), the knee (188/720, 26.11%), and the dorsal aspects of hands (437/720, 60.69%). Phylogenetic analysis showed the CV-A6 isolates in this study belonged to Cluster A1 and were similar to those found in Shanghai in 2011 and 2012 (JX495148, KC414735), Shenzhen in 2011 (JX473394), Japan in 2011 (AB649243, AB649246), France in 2010(HE572928), Thailand in 2012(JX556564) and Israel in 2012 and 2013(.KF991010, KF991012). SN - 1743-422X UR - https://www.unboundmedicine.com/medline/citation/25178398/Circulation_of_Coxsackievirus_A6_in_hand_foot_mouth_disease_in_Guangzhou_2010_2012_ L2 - https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-11-157 DB - PRIME DP - Unbound Medicine ER -