Tags

Type your tag names separated by a space and hit enter

Signaling of hydrogen sulfide and polysulfides.
Antioxid Redox Signal. 2015 Feb 10; 22(5):347-9.AR

Abstract

It has been almost two decades since the first demonstration of hydrogen sulfide (H2S) as a physiological mediator of cognitive function and vascular tone. H2S is physiologically important because it protects various organs from ischemia-reperfusion injury besides regulating inflammation, oxygen sensing, cell growth, and senescence. The production, metabolism, and regulation of H2S have been studied extensively. H2S modulates target proteins through sulfhydration (or sulfuration) or by the reduction of cysteine disulfide bonds. A large number of novel H2S-donating compounds are being developed owing to the therapeutic potential of H2S. Recently, polysulfides, rather than H2S, have been identified as molecules that sulfhydrate (or sulfurate) their target proteins.

Authors+Show Affiliations

Department of Molecular Pharmacology, National Institute of Neuroscience , Kodaira, Tokyo, Japan .

Pub Type(s)

Editorial
Introductory Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25178405

Citation

Kimura, Hideo. "Signaling of Hydrogen Sulfide and Polysulfides." Antioxidants & Redox Signaling, vol. 22, no. 5, 2015, pp. 347-9.
Kimura H. Signaling of hydrogen sulfide and polysulfides. Antioxid Redox Signal. 2015;22(5):347-9.
Kimura, H. (2015). Signaling of hydrogen sulfide and polysulfides. Antioxidants & Redox Signaling, 22(5), 347-9. https://doi.org/10.1089/ars.2014.6082
Kimura H. Signaling of Hydrogen Sulfide and Polysulfides. Antioxid Redox Signal. 2015 Feb 10;22(5):347-9. PubMed PMID: 25178405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Signaling of hydrogen sulfide and polysulfides. A1 - Kimura,Hideo, Y1 - 2014/10/09/ PY - 2014/9/3/entrez PY - 2014/9/3/pubmed PY - 2015/11/18/medline SP - 347 EP - 9 JF - Antioxidants & redox signaling JO - Antioxid Redox Signal VL - 22 IS - 5 N2 - It has been almost two decades since the first demonstration of hydrogen sulfide (H2S) as a physiological mediator of cognitive function and vascular tone. H2S is physiologically important because it protects various organs from ischemia-reperfusion injury besides regulating inflammation, oxygen sensing, cell growth, and senescence. The production, metabolism, and regulation of H2S have been studied extensively. H2S modulates target proteins through sulfhydration (or sulfuration) or by the reduction of cysteine disulfide bonds. A large number of novel H2S-donating compounds are being developed owing to the therapeutic potential of H2S. Recently, polysulfides, rather than H2S, have been identified as molecules that sulfhydrate (or sulfurate) their target proteins. SN - 1557-7716 UR - https://www.unboundmedicine.com/medline/citation/25178405/Signaling_of_hydrogen_sulfide_and_polysulfides_ L2 - https://www.liebertpub.com/doi/10.1089/ars.2014.6082?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -