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Grade-response relationship between blood pressure and severity of coronary atherosclerosis in asymptomatic adults: assessment with coronary CT angiography.
Int J Cardiovasc Imaging. 2014 Dec; 30 Suppl 2:105-12.IJ

Abstract

Hypertension is known to be a strong risk factor for coronary atherosclerosis. We aimed to investigate the prevalence, severity, and plaque characteristics of coronary atherosclerosis according to grade of blood pressure (BP) using coronary CT angiography (CCTA) in asymptomatic adults. We enrolled 8,238 asymptomatic subjects who underwent coronary artery calcium scoring (CACS) and CCTA for health screening purposes. Subjects were classified according to JNC 7 guidelines (normal, systolic BP/diastolic BP < 120/80; pre-hypertension [PH], 120-139/80-89; hypertension stage 1 [H1], 140-159/90-99; hypertension stage 2 [H2], >160/100). Isolated systolic hypertension (ISH; systolic BP > 140, diastolic BP < 80) was additionally categorized. With CCTA, the presence of plaques, severity of stenosis, and plaque types were assessed. Using multiple logistic regression analysis, the adjusted odds ratios (AORs) for plaque, obstructive coronary artery disease (CAD) (luminal stenosis ≥50 %), non-calcified plaque (NCP), and CACS > 100 were assessed according to BP grade. After adjustment for clinical risk factors, the risk of subclinical atherosclerosis, NCP, and CACS > 100 gradually increased from PH stage (all P values for trend <0.05), while the risk of obstructive CAD increased from the H1 stage (AORs of H1 and H2: 1.70 and 2.33, respectively). In the ISH group, the AOR of subclinical atherosclerosis (1.64) was higher than in the H1 group (1.55), while the AOR of obstructive CAD (2.58) was higher than in the H2 group (2.33). Therefore, our study strongly suggests that coronary atherosclerosis in asymptomatic adults shows a grade-response relationship according to hypertension grade.

Authors+Show Affiliations

Department of Radiology, Seoul National University Bundang Hospital, Gyeonggido, 436-707, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25178841

Citation

Im, Tae Seong, et al. "Grade-response Relationship Between Blood Pressure and Severity of Coronary Atherosclerosis in Asymptomatic Adults: Assessment With Coronary CT Angiography." The International Journal of Cardiovascular Imaging, vol. 30 Suppl 2, 2014, pp. 105-12.
Im TS, Chun EJ, Lee MS, et al. Grade-response relationship between blood pressure and severity of coronary atherosclerosis in asymptomatic adults: assessment with coronary CT angiography. Int J Cardiovasc Imaging. 2014;30 Suppl 2:105-12.
Im, T. S., Chun, E. J., Lee, M. S., Adla, T., Kim, J. A., & Choi, S. I. (2014). Grade-response relationship between blood pressure and severity of coronary atherosclerosis in asymptomatic adults: assessment with coronary CT angiography. The International Journal of Cardiovascular Imaging, 30 Suppl 2, 105-12. https://doi.org/10.1007/s10554-014-0522-9
Im TS, et al. Grade-response Relationship Between Blood Pressure and Severity of Coronary Atherosclerosis in Asymptomatic Adults: Assessment With Coronary CT Angiography. Int J Cardiovasc Imaging. 2014;30 Suppl 2:105-12. PubMed PMID: 25178841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Grade-response relationship between blood pressure and severity of coronary atherosclerosis in asymptomatic adults: assessment with coronary CT angiography. AU - Im,Tae Seong, AU - Chun,Eun Ju, AU - Lee,Min Su, AU - Adla,Theodor, AU - Kim,Jeong A, AU - Choi,Sang Il, Y1 - 2014/09/02/ PY - 2014/07/29/received PY - 2014/08/12/accepted PY - 2014/9/3/entrez PY - 2014/9/3/pubmed PY - 2015/7/7/medline SP - 105 EP - 12 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 30 Suppl 2 N2 - Hypertension is known to be a strong risk factor for coronary atherosclerosis. We aimed to investigate the prevalence, severity, and plaque characteristics of coronary atherosclerosis according to grade of blood pressure (BP) using coronary CT angiography (CCTA) in asymptomatic adults. We enrolled 8,238 asymptomatic subjects who underwent coronary artery calcium scoring (CACS) and CCTA for health screening purposes. Subjects were classified according to JNC 7 guidelines (normal, systolic BP/diastolic BP < 120/80; pre-hypertension [PH], 120-139/80-89; hypertension stage 1 [H1], 140-159/90-99; hypertension stage 2 [H2], >160/100). Isolated systolic hypertension (ISH; systolic BP > 140, diastolic BP < 80) was additionally categorized. With CCTA, the presence of plaques, severity of stenosis, and plaque types were assessed. Using multiple logistic regression analysis, the adjusted odds ratios (AORs) for plaque, obstructive coronary artery disease (CAD) (luminal stenosis ≥50 %), non-calcified plaque (NCP), and CACS > 100 were assessed according to BP grade. After adjustment for clinical risk factors, the risk of subclinical atherosclerosis, NCP, and CACS > 100 gradually increased from PH stage (all P values for trend <0.05), while the risk of obstructive CAD increased from the H1 stage (AORs of H1 and H2: 1.70 and 2.33, respectively). In the ISH group, the AOR of subclinical atherosclerosis (1.64) was higher than in the H1 group (1.55), while the AOR of obstructive CAD (2.58) was higher than in the H2 group (2.33). Therefore, our study strongly suggests that coronary atherosclerosis in asymptomatic adults shows a grade-response relationship according to hypertension grade. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/25178841/Grade_response_relationship_between_blood_pressure_and_severity_of_coronary_atherosclerosis_in_asymptomatic_adults:_assessment_with_coronary_CT_angiography_ L2 - https://doi.org/10.1007/s10554-014-0522-9 DB - PRIME DP - Unbound Medicine ER -