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Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome.
Gut Microbes. 2014 May-Jun; 5(3):430-6.GM

Abstract

The last ten years' wide progress in the gut microbiota phylogenetic and functional characterization has been made evidencing dysbiosis in several gastrointestinal diseases including inflammatory bowel diseases and irritable bowel syndrome (IBS). IBS is a functional gut disease with high prevalence and negative impact on patient's quality of life characterized mainly by visceral pain and/or discomfort, representing a good paradigm of chronic gut hypersensitivity. The IBS features are strongly regulated by bidirectional gut-brain interactions and there is increasing evidence for the involvement of gut bacteria and/or their metabolites in these features, including visceral pain. Further, gut microbiota modulation by antibiotics or probiotics has been promising in IBS. Mechanistic data provided mainly by animal studies highlight that commensals or probiotics may exert a direct action through bacterial metabolites on sensitive nerve endings in the gut mucosa, or indirect pathways targeting the intestinal epithelial barrier, the mucosal and/or systemic immune activation, and subsequent neuronal sensitization and/or activation.

Authors+Show Affiliations

INRA; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; El-Purpan; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France.INRA; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; El-Purpan; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; Lallemand Health Solutions Inc; Montreal, Canada.INRA; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; El-Purpan; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France.INRA; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; El-Purpan; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25184834

Citation

Theodorou, Vassilia, et al. "Effect of Commensals and Probiotics On Visceral Sensitivity and Pain in Irritable Bowel Syndrome." Gut Microbes, vol. 5, no. 3, 2014, pp. 430-6.
Theodorou V, Ait Belgnaoui A, Agostini S, et al. Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome. Gut Microbes. 2014;5(3):430-6.
Theodorou, V., Ait Belgnaoui, A., Agostini, S., & Eutamene, H. (2014). Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome. Gut Microbes, 5(3), 430-6. https://doi.org/10.4161/gmic.29796
Theodorou V, et al. Effect of Commensals and Probiotics On Visceral Sensitivity and Pain in Irritable Bowel Syndrome. Gut Microbes. 2014 May-Jun;5(3):430-6. PubMed PMID: 25184834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome. AU - Theodorou,Vassilia, AU - Ait Belgnaoui,Afifa, AU - Agostini,Simona, AU - Eutamene,Helene, PY - 2014/9/4/entrez PY - 2014/9/4/pubmed PY - 2015/5/20/medline KW - brain-gut axis KW - gut permeability KW - intestinal barrier KW - irritable bowel syndrome KW - microbiota KW - probiotics KW - stress KW - visceral pain SP - 430 EP - 6 JF - Gut microbes JO - Gut Microbes VL - 5 IS - 3 N2 - The last ten years' wide progress in the gut microbiota phylogenetic and functional characterization has been made evidencing dysbiosis in several gastrointestinal diseases including inflammatory bowel diseases and irritable bowel syndrome (IBS). IBS is a functional gut disease with high prevalence and negative impact on patient's quality of life characterized mainly by visceral pain and/or discomfort, representing a good paradigm of chronic gut hypersensitivity. The IBS features are strongly regulated by bidirectional gut-brain interactions and there is increasing evidence for the involvement of gut bacteria and/or their metabolites in these features, including visceral pain. Further, gut microbiota modulation by antibiotics or probiotics has been promising in IBS. Mechanistic data provided mainly by animal studies highlight that commensals or probiotics may exert a direct action through bacterial metabolites on sensitive nerve endings in the gut mucosa, or indirect pathways targeting the intestinal epithelial barrier, the mucosal and/or systemic immune activation, and subsequent neuronal sensitization and/or activation. SN - 1949-0984 UR - https://www.unboundmedicine.com/medline/citation/25184834/Effect_of_commensals_and_probiotics_on_visceral_sensitivity_and_pain_in_irritable_bowel_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.4161/gmic.29796 DB - PRIME DP - Unbound Medicine ER -