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Alcohol consumption and persistent infection of high-risk human papillomavirus.

Abstract

Alcohol consumption is a possible co-factor of high-risk human papillomavirus (HR-HPV) persistence, a major step in cervical carcinogenesis, but the association between alcohol and continuous HPV infection remains unclear. This prospective study identified the association between alcohol consumption and HR-HPV persistence. Overall, 9230 women who underwent screening during 2002-2011 at the National Cancer Center, Korea were analysed in multivariate logistic regression. Current drinkers [odds ratio (OR) 2·49, 95% confidence interval (CI) 1·32-4·71] and drinkers for ⩾5 years (OR 2·33, 95% CI 1·17-4·63) had a higher risk of 2-year HR-HPV persistence (HPV positivity for 3 consecutive years) than non-drinkers and drinkers for <5 years, respectively (vs. HPV negativity for 3 consecutive years). A high drinking frequency (⩾twice/week) and a high beer intake (⩾3 glasses/occasion) had higher risks of 1-year (OR 1·80, 95% CI 1·01-3·36) HPV positivity for 2 consecutive years) and 2-year HR-HPV persistence (OR 3·62, 95% CI 1·35-9·75) than non-drinkers. Of the HPV-positive subjects enrolled, drinking habit (OR 2·68, 95% CI 1·10-6·51) and high consumption of beer or soju (⩾2 glasses/occasion; OR 2·90, 95% CI 1·06-7·98) increased the risk of 2-year consecutive or alternate HR-HPV positivity (vs. consecutive HPV negativity). These findings suggest that alcohol consumption might increase the risk of cervical HR-HPV persistence in Korean women.

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  • Authors+Show Affiliations

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    Translational Epidemiology Branch,Division of Cancer Epidemiology and Prevention,National Cancer Center,Gyeonggi-do,Korea.

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    Translational Epidemiology Branch,Division of Cancer Epidemiology and Prevention,National Cancer Center,Gyeonggi-do,Korea.

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    Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.

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    Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.

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    Center for Cancer Prevention and Detection, Hospital, National Cancer Center,Gyeonggi-do,Korea.

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    Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.

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    Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.

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    Center for Cancer Prevention and Detection, Hospital, National Cancer Center,Gyeonggi-do,Korea.

    Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.

    Source

    Epidemiology and infection 143:7 2015 May pg 1442-50

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Female
    Humans
    Incidence
    Logistic Models
    Middle Aged
    Odds Ratio
    Papillomaviridae
    Papillomavirus Infections
    Prospective Studies
    Republic of Korea
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25185457

    Citation

    Oh, H Y., et al. "Alcohol Consumption and Persistent Infection of High-risk Human Papillomavirus." Epidemiology and Infection, vol. 143, no. 7, 2015, pp. 1442-50.
    Oh HY, Kim MK, Seo S, et al. Alcohol consumption and persistent infection of high-risk human papillomavirus. Epidemiol Infect. 2015;143(7):1442-50.
    Oh, H. Y., Kim, M. K., Seo, S., Lee, D. O., Chung, Y. K., Lim, M. C., ... Park, S. (2015). Alcohol consumption and persistent infection of high-risk human papillomavirus. Epidemiology and Infection, 143(7), pp. 1442-50. doi:10.1017/S0950268814002258.
    Oh HY, et al. Alcohol Consumption and Persistent Infection of High-risk Human Papillomavirus. Epidemiol Infect. 2015;143(7):1442-50. PubMed PMID: 25185457.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and persistent infection of high-risk human papillomavirus. AU - Oh,H Y, AU - Kim,M K, AU - Seo,S, AU - Lee,D O, AU - Chung,Y K, AU - Lim,M C, AU - Kim,J, AU - Lee,C W, AU - Park,S, Y1 - 2014/09/04/ PY - 2014/9/5/entrez PY - 2014/9/5/pubmed PY - 2015/6/3/medline KW - persistence SP - 1442 EP - 50 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 143 IS - 7 N2 - Alcohol consumption is a possible co-factor of high-risk human papillomavirus (HR-HPV) persistence, a major step in cervical carcinogenesis, but the association between alcohol and continuous HPV infection remains unclear. This prospective study identified the association between alcohol consumption and HR-HPV persistence. Overall, 9230 women who underwent screening during 2002-2011 at the National Cancer Center, Korea were analysed in multivariate logistic regression. Current drinkers [odds ratio (OR) 2·49, 95% confidence interval (CI) 1·32-4·71] and drinkers for ⩾5 years (OR 2·33, 95% CI 1·17-4·63) had a higher risk of 2-year HR-HPV persistence (HPV positivity for 3 consecutive years) than non-drinkers and drinkers for <5 years, respectively (vs. HPV negativity for 3 consecutive years). A high drinking frequency (⩾twice/week) and a high beer intake (⩾3 glasses/occasion) had higher risks of 1-year (OR 1·80, 95% CI 1·01-3·36) HPV positivity for 2 consecutive years) and 2-year HR-HPV persistence (OR 3·62, 95% CI 1·35-9·75) than non-drinkers. Of the HPV-positive subjects enrolled, drinking habit (OR 2·68, 95% CI 1·10-6·51) and high consumption of beer or soju (⩾2 glasses/occasion; OR 2·90, 95% CI 1·06-7·98) increased the risk of 2-year consecutive or alternate HR-HPV positivity (vs. consecutive HPV negativity). These findings suggest that alcohol consumption might increase the risk of cervical HR-HPV persistence in Korean women. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/25185457/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0950268814002258/type/journal_article DB - PRIME DP - Unbound Medicine ER -