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Alcohol consumption and persistent infection of high-risk human papillomavirus.
Epidemiol Infect 2015; 143(7):1442-50EI

Abstract

Alcohol consumption is a possible co-factor of high-risk human papillomavirus (HR-HPV) persistence, a major step in cervical carcinogenesis, but the association between alcohol and continuous HPV infection remains unclear. This prospective study identified the association between alcohol consumption and HR-HPV persistence. Overall, 9230 women who underwent screening during 2002-2011 at the National Cancer Center, Korea were analysed in multivariate logistic regression. Current drinkers [odds ratio (OR) 2·49, 95% confidence interval (CI) 1·32-4·71] and drinkers for ⩾5 years (OR 2·33, 95% CI 1·17-4·63) had a higher risk of 2-year HR-HPV persistence (HPV positivity for 3 consecutive years) than non-drinkers and drinkers for <5 years, respectively (vs. HPV negativity for 3 consecutive years). A high drinking frequency (⩾twice/week) and a high beer intake (⩾3 glasses/occasion) had higher risks of 1-year (OR 1·80, 95% CI 1·01-3·36) HPV positivity for 2 consecutive years) and 2-year HR-HPV persistence (OR 3·62, 95% CI 1·35-9·75) than non-drinkers. Of the HPV-positive subjects enrolled, drinking habit (OR 2·68, 95% CI 1·10-6·51) and high consumption of beer or soju (⩾2 glasses/occasion; OR 2·90, 95% CI 1·06-7·98) increased the risk of 2-year consecutive or alternate HR-HPV positivity (vs. consecutive HPV negativity). These findings suggest that alcohol consumption might increase the risk of cervical HR-HPV persistence in Korean women.

Authors+Show Affiliations

Translational Epidemiology Branch,Division of Cancer Epidemiology and Prevention,National Cancer Center,Gyeonggi-do,Korea.Translational Epidemiology Branch,Division of Cancer Epidemiology and Prevention,National Cancer Center,Gyeonggi-do,Korea.Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.Center for Cancer Prevention and Detection, Hospital, National Cancer Center,Gyeonggi-do,Korea.Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.Center for Cancer Prevention and Detection, Hospital, National Cancer Center,Gyeonggi-do,Korea.Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25185457

Citation

Oh, H Y., et al. "Alcohol Consumption and Persistent Infection of High-risk Human Papillomavirus." Epidemiology and Infection, vol. 143, no. 7, 2015, pp. 1442-50.
Oh HY, Kim MK, Seo S, et al. Alcohol consumption and persistent infection of high-risk human papillomavirus. Epidemiol Infect. 2015;143(7):1442-50.
Oh, H. Y., Kim, M. K., Seo, S., Lee, D. O., Chung, Y. K., Lim, M. C., ... Park, S. (2015). Alcohol consumption and persistent infection of high-risk human papillomavirus. Epidemiology and Infection, 143(7), pp. 1442-50. doi:10.1017/S0950268814002258.
Oh HY, et al. Alcohol Consumption and Persistent Infection of High-risk Human Papillomavirus. Epidemiol Infect. 2015;143(7):1442-50. PubMed PMID: 25185457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and persistent infection of high-risk human papillomavirus. AU - Oh,H Y, AU - Kim,M K, AU - Seo,S, AU - Lee,D O, AU - Chung,Y K, AU - Lim,M C, AU - Kim,J, AU - Lee,C W, AU - Park,S, Y1 - 2014/09/04/ PY - 2014/9/5/entrez PY - 2014/9/5/pubmed PY - 2015/6/3/medline KW - persistence SP - 1442 EP - 50 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 143 IS - 7 N2 - Alcohol consumption is a possible co-factor of high-risk human papillomavirus (HR-HPV) persistence, a major step in cervical carcinogenesis, but the association between alcohol and continuous HPV infection remains unclear. This prospective study identified the association between alcohol consumption and HR-HPV persistence. Overall, 9230 women who underwent screening during 2002-2011 at the National Cancer Center, Korea were analysed in multivariate logistic regression. Current drinkers [odds ratio (OR) 2·49, 95% confidence interval (CI) 1·32-4·71] and drinkers for ⩾5 years (OR 2·33, 95% CI 1·17-4·63) had a higher risk of 2-year HR-HPV persistence (HPV positivity for 3 consecutive years) than non-drinkers and drinkers for <5 years, respectively (vs. HPV negativity for 3 consecutive years). A high drinking frequency (⩾twice/week) and a high beer intake (⩾3 glasses/occasion) had higher risks of 1-year (OR 1·80, 95% CI 1·01-3·36) HPV positivity for 2 consecutive years) and 2-year HR-HPV persistence (OR 3·62, 95% CI 1·35-9·75) than non-drinkers. Of the HPV-positive subjects enrolled, drinking habit (OR 2·68, 95% CI 1·10-6·51) and high consumption of beer or soju (⩾2 glasses/occasion; OR 2·90, 95% CI 1·06-7·98) increased the risk of 2-year consecutive or alternate HR-HPV positivity (vs. consecutive HPV negativity). These findings suggest that alcohol consumption might increase the risk of cervical HR-HPV persistence in Korean women. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/25185457/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0950268814002258/type/journal_article DB - PRIME DP - Unbound Medicine ER -