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Dietary fat intake and risk for Parkinson's disease.
Mov Disord 2014; 29(13):1623-30MD

Abstract

Previous epidemiological studies have generated inconsistent results regarding the associations between dietary fat intakes and risk for Parkinson's disease (PD). We therefore prospectively examined these associations in the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study. A 124-item food frequency questionnaire was administered at baseline in1995 to 1996, and PD diagnosis was self-reported at the follow-up survey in 2004 to 2006. A total of 1,087 cases with a PD diagnosis between 2000 and 2006 and 299,617 controls were included in the analyses. Overall, intakes of fats and other macronutrients were not associated with PD risk. However, we found a weak positive association between n-6 polyunsaturated fatty acids (PUFA) and the risk for PD. After adjusting for potential confounders, the odds ratio (OR) and 95% confidence interval (CI) between extreme quintiles of n-6 PUFA intake was 1.23 (95% CI = 1.02-1.49, P for trend = 0.02). A similar association was observed for the intake of linoleic acid. Results were similar among men and among women. Our study suggests that fat intake in general is not related to the risk for PD. The weak positive association between intake of n-6 PUFA and PD risk needs further investigation.

Authors+Show Affiliations

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

25186946

Citation

Dong, Jing, et al. "Dietary Fat Intake and Risk for Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 29, no. 13, 2014, pp. 1623-30.
Dong J, Beard JD, Umbach DM, et al. Dietary fat intake and risk for Parkinson's disease. Mov Disord. 2014;29(13):1623-30.
Dong, J., Beard, J. D., Umbach, D. M., Park, Y., Huang, X., Blair, A., ... Chen, H. (2014). Dietary fat intake and risk for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 29(13), pp. 1623-30. doi:10.1002/mds.26032.
Dong J, et al. Dietary Fat Intake and Risk for Parkinson's Disease. Mov Disord. 2014;29(13):1623-30. PubMed PMID: 25186946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake and risk for Parkinson's disease. AU - Dong,Jing, AU - Beard,John D, AU - Umbach,David M, AU - Park,YikYung, AU - Huang,Xuemei, AU - Blair,Aaron, AU - Kamel,Freya, AU - Chen,Honglei, Y1 - 2014/09/03/ PY - 2014/04/21/received PY - 2014/08/04/revised PY - 2014/08/25/accepted PY - 2014/9/5/entrez PY - 2014/9/5/pubmed PY - 2015/6/24/medline KW - Parkinson's disease KW - cohort study KW - dietary fat intake SP - 1623 EP - 30 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 29 IS - 13 N2 - Previous epidemiological studies have generated inconsistent results regarding the associations between dietary fat intakes and risk for Parkinson's disease (PD). We therefore prospectively examined these associations in the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study. A 124-item food frequency questionnaire was administered at baseline in1995 to 1996, and PD diagnosis was self-reported at the follow-up survey in 2004 to 2006. A total of 1,087 cases with a PD diagnosis between 2000 and 2006 and 299,617 controls were included in the analyses. Overall, intakes of fats and other macronutrients were not associated with PD risk. However, we found a weak positive association between n-6 polyunsaturated fatty acids (PUFA) and the risk for PD. After adjusting for potential confounders, the odds ratio (OR) and 95% confidence interval (CI) between extreme quintiles of n-6 PUFA intake was 1.23 (95% CI = 1.02-1.49, P for trend = 0.02). A similar association was observed for the intake of linoleic acid. Results were similar among men and among women. Our study suggests that fat intake in general is not related to the risk for PD. The weak positive association between intake of n-6 PUFA and PD risk needs further investigation. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/25186946/Dietary_fat_intake_and_risk_for_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.26032 DB - PRIME DP - Unbound Medicine ER -