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Analysis of eight glycols in serum using LC-ESI-MS-MS.
J Anal Toxicol. 2014 Nov-Dec; 38(9):676-80.JA

Abstract

A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters were tested: linearity, repeatability and intermediate precision, limits of detection and quantification, carry over and ion suppression. Limits of detection were between 0.18 and 1.1 mg/L, and limits of quantification were between 0.4 and 2.3 mg/L. Separation of isomers was possible either chromatographically or by selecting specific multiple reaction monitoring transitions. This method could be a useful tool in case of suspected intoxication with antifreeze agents, solvents, dietary supplements or some medical drug compounds.

Authors+Show Affiliations

Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France laurent.imbert@ch-havre.fr.Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France.Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25187402

Citation

Imbert, Laurent, et al. "Analysis of Eight Glycols in Serum Using LC-ESI-MS-MS." Journal of Analytical Toxicology, vol. 38, no. 9, 2014, pp. 676-80.
Imbert L, Saussereau E, Lacroix C. Analysis of eight glycols in serum using LC-ESI-MS-MS. J Anal Toxicol. 2014;38(9):676-80.
Imbert, L., Saussereau, E., & Lacroix, C. (2014). Analysis of eight glycols in serum using LC-ESI-MS-MS. Journal of Analytical Toxicology, 38(9), 676-80. https://doi.org/10.1093/jat/bku100
Imbert L, Saussereau E, Lacroix C. Analysis of Eight Glycols in Serum Using LC-ESI-MS-MS. J Anal Toxicol. 2014 Nov-Dec;38(9):676-80. PubMed PMID: 25187402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of eight glycols in serum using LC-ESI-MS-MS. AU - Imbert,Laurent, AU - Saussereau,Elodie, AU - Lacroix,Christian, Y1 - 2014/09/03/ PY - 2014/9/5/entrez PY - 2014/9/5/pubmed PY - 2015/7/24/medline SP - 676 EP - 80 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 38 IS - 9 N2 - A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters were tested: linearity, repeatability and intermediate precision, limits of detection and quantification, carry over and ion suppression. Limits of detection were between 0.18 and 1.1 mg/L, and limits of quantification were between 0.4 and 2.3 mg/L. Separation of isomers was possible either chromatographically or by selecting specific multiple reaction monitoring transitions. This method could be a useful tool in case of suspected intoxication with antifreeze agents, solvents, dietary supplements or some medical drug compounds. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/25187402/Analysis_of_eight_glycols_in_serum_using_LC_ESI_MS_MS_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bku100 DB - PRIME DP - Unbound Medicine ER -