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Relationship between non-alcoholic fatty liver disease and benign prostatic hyperplasia/lower urinary tract symptoms: new insights from an Italian cross-sectional study.
World J Urol. 2015 May; 33(5):743-51.WJ

Abstract

PURPOSE

To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) assessed by the fatty liver index (FLI), in lower urinary tract symptoms (LUTS) patients and to estimate its ability in predicting LUTS.

METHODS

We performed a cross-sectional analysis of 448 consecutive patients affected by LUTS. LUTS were evaluated using the IPSS questionnaire and metabolic syndrome (MetS) criteria (by International Diabetes Federation). FLI, prostate volume (PV), serum prostate-specific antigen, total testosterone (TT) and homeostasis model assessment (HOMA) index were evaluated. A value of FLI ≥40 was set to predict NAFLD. Patients were divided into Group A (FLI <40) and Group B (FLI ≥40). Odds ratios (OR) for having moderate-severe LUTS were calculated. Logistic regression model was fitted adjusting for confounding factors.

RESULTS

Group B showed higher prevalence of MetS, IR, moderate-severe LUTS and ED, higher IPSS, IPSS-storage, IPSS-voiding, total prostate volume, insulin, HOMA and lower TT and IIEF-5. Univariate logistic regression analysis demonstrated that continuous FLI (OR = 1.03, p < 0.05) and FLI ≥40 (OR = 2.41, p < 0.01) significantly increase the risk of moderate-severe LUTS. Continuous FLI (OR = 1.12, p < 0.01) and FLI ≥40 (OR = 5.39, p < 0.01) were independent predictors of moderate-severe LUTS at the multivariate logistic regression analysis, after adjusting for confounding factors. Subjects with MetS and FLI ≥40 had 2.0-fold the risk of moderate-severe LUTS (OR = 2.10, p < 0.01).

CONCLUSIONS

Non-alcoholic fatty liver disease (NAFLD) subjects have higher risk of LUTS. The presence of FLI ≥40 can be used to predict subjects at high risk of LUTS.

Authors+Show Affiliations

Department of Urology, School of Medicine Policlinico Hospital, University of Catania, Catania, Italy, giorgioivan@virgilio.it.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25189458

Citation

Russo, Giorgio Ivan, et al. "Relationship Between Non-alcoholic Fatty Liver Disease and Benign Prostatic Hyperplasia/lower Urinary Tract Symptoms: New Insights From an Italian Cross-sectional Study." World Journal of Urology, vol. 33, no. 5, 2015, pp. 743-51.
Russo GI, Cimino S, Fragalà E, et al. Relationship between non-alcoholic fatty liver disease and benign prostatic hyperplasia/lower urinary tract symptoms: new insights from an Italian cross-sectional study. World J Urol. 2015;33(5):743-51.
Russo, G. I., Cimino, S., Fragalà, E., Privitera, S., La Vignera, S., Condorelli, R., Calogero, A. E., Chisari, M., Castelli, T., Favilla, V., & Morgia, G. (2015). Relationship between non-alcoholic fatty liver disease and benign prostatic hyperplasia/lower urinary tract symptoms: new insights from an Italian cross-sectional study. World Journal of Urology, 33(5), 743-51. https://doi.org/10.1007/s00345-014-1392-4
Russo GI, et al. Relationship Between Non-alcoholic Fatty Liver Disease and Benign Prostatic Hyperplasia/lower Urinary Tract Symptoms: New Insights From an Italian Cross-sectional Study. World J Urol. 2015;33(5):743-51. PubMed PMID: 25189458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between non-alcoholic fatty liver disease and benign prostatic hyperplasia/lower urinary tract symptoms: new insights from an Italian cross-sectional study. AU - Russo,Giorgio Ivan, AU - Cimino,Sebastiano, AU - Fragalà,Eugenia, AU - Privitera,Salvatore, AU - La Vignera,Sandro, AU - Condorelli,Rosita, AU - Calogero,Aldo E, AU - Chisari,Mario, AU - Castelli,Tommaso, AU - Favilla,Vincenzo, AU - Morgia,Giuseppe, Y1 - 2014/09/05/ PY - 2014/04/15/received PY - 2014/07/31/accepted PY - 2014/9/6/entrez PY - 2014/9/6/pubmed PY - 2016/2/13/medline SP - 743 EP - 51 JF - World journal of urology JO - World J Urol VL - 33 IS - 5 N2 - PURPOSE: To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) assessed by the fatty liver index (FLI), in lower urinary tract symptoms (LUTS) patients and to estimate its ability in predicting LUTS. METHODS: We performed a cross-sectional analysis of 448 consecutive patients affected by LUTS. LUTS were evaluated using the IPSS questionnaire and metabolic syndrome (MetS) criteria (by International Diabetes Federation). FLI, prostate volume (PV), serum prostate-specific antigen, total testosterone (TT) and homeostasis model assessment (HOMA) index were evaluated. A value of FLI ≥40 was set to predict NAFLD. Patients were divided into Group A (FLI <40) and Group B (FLI ≥40). Odds ratios (OR) for having moderate-severe LUTS were calculated. Logistic regression model was fitted adjusting for confounding factors. RESULTS: Group B showed higher prevalence of MetS, IR, moderate-severe LUTS and ED, higher IPSS, IPSS-storage, IPSS-voiding, total prostate volume, insulin, HOMA and lower TT and IIEF-5. Univariate logistic regression analysis demonstrated that continuous FLI (OR = 1.03, p < 0.05) and FLI ≥40 (OR = 2.41, p < 0.01) significantly increase the risk of moderate-severe LUTS. Continuous FLI (OR = 1.12, p < 0.01) and FLI ≥40 (OR = 5.39, p < 0.01) were independent predictors of moderate-severe LUTS at the multivariate logistic regression analysis, after adjusting for confounding factors. Subjects with MetS and FLI ≥40 had 2.0-fold the risk of moderate-severe LUTS (OR = 2.10, p < 0.01). CONCLUSIONS: Non-alcoholic fatty liver disease (NAFLD) subjects have higher risk of LUTS. The presence of FLI ≥40 can be used to predict subjects at high risk of LUTS. SN - 1433-8726 UR - https://www.unboundmedicine.com/medline/citation/25189458/Relationship_between_non_alcoholic_fatty_liver_disease_and_benign_prostatic_hyperplasia/lower_urinary_tract_symptoms:_new_insights_from_an_Italian_cross_sectional_study_ L2 - https://dx.doi.org/10.1007/s00345-014-1392-4 DB - PRIME DP - Unbound Medicine ER -