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Preparation and pharmacokinetics study on gastro-floating sustained-release tablets of troxipide.
Drug Dev Ind Pharm. 2015; 41(9):1443-51.DD

Abstract

The purpose of this research aimed at preparing gastro-floating sustained-release tablets of troxipide and a further study on in vitro release and in vivo bioavailability. Under the circumstances of direct powder compression, the floating tablets were successfully prepared with HPMC as main matrix material, Carbopol as assistant matrix material, octadecanol as floating agent and sodium bicarbonate as foaming agent to float by gas-forming. The floating time and accumulative release amount as evaluation indexes were utilized to perform pre-experiment screening and single-factor test, respectively, while central composite design response surface method was applied for formulation optimization, followed by in vivo pharmacokinetic study in beagles after oral administration for floating tablets and commercial tablets used as the control. The results indicated that the floating sustained-release tablets held a better capability for floating and drug release and more satisfactory pharmacokinetic parameters, such as a lower Cmax, a prolonged Tmax, but an equivalent bioavailability calculated by AUC0-24 compared to commercial tablets. So a conclusion was finally drawn that the floating sustained-release tablets possessing a good release property could be suitable for demands of design.

Authors+Show Affiliations

a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , China .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25190152

Citation

Gao, Yunyun, et al. "Preparation and Pharmacokinetics Study On Gastro-floating Sustained-release Tablets of Troxipide." Drug Development and Industrial Pharmacy, vol. 41, no. 9, 2015, pp. 1443-51.
Gao Y, Gao Y, Yin F, et al. Preparation and pharmacokinetics study on gastro-floating sustained-release tablets of troxipide. Drug Dev Ind Pharm. 2015;41(9):1443-51.
Gao, Y., Gao, Y., Yin, F., Wang, M., Wang, Z., Ye, T., Yang, Y., Pan, W. S., & Yang, X. (2015). Preparation and pharmacokinetics study on gastro-floating sustained-release tablets of troxipide. Drug Development and Industrial Pharmacy, 41(9), 1443-51. https://doi.org/10.3109/03639045.2014.956113
Gao Y, et al. Preparation and Pharmacokinetics Study On Gastro-floating Sustained-release Tablets of Troxipide. Drug Dev Ind Pharm. 2015;41(9):1443-51. PubMed PMID: 25190152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and pharmacokinetics study on gastro-floating sustained-release tablets of troxipide. AU - Gao,Yunyun, AU - Gao,Yang, AU - Yin,Fei, AU - Wang,Mi, AU - Wang,Zhenhong, AU - Ye,Tiantian, AU - Yang,Yonggang, AU - Pan,W S, AU - Yang,Xinggang, Y1 - 2015/07/21/ PY - 2014/9/6/entrez PY - 2014/9/6/pubmed PY - 2016/6/2/medline KW - Accumulative release amount KW - bioavailability KW - floating sustained-release tablet KW - floating time KW - troxipide SP - 1443 EP - 51 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 41 IS - 9 N2 - The purpose of this research aimed at preparing gastro-floating sustained-release tablets of troxipide and a further study on in vitro release and in vivo bioavailability. Under the circumstances of direct powder compression, the floating tablets were successfully prepared with HPMC as main matrix material, Carbopol as assistant matrix material, octadecanol as floating agent and sodium bicarbonate as foaming agent to float by gas-forming. The floating time and accumulative release amount as evaluation indexes were utilized to perform pre-experiment screening and single-factor test, respectively, while central composite design response surface method was applied for formulation optimization, followed by in vivo pharmacokinetic study in beagles after oral administration for floating tablets and commercial tablets used as the control. The results indicated that the floating sustained-release tablets held a better capability for floating and drug release and more satisfactory pharmacokinetic parameters, such as a lower Cmax, a prolonged Tmax, but an equivalent bioavailability calculated by AUC0-24 compared to commercial tablets. So a conclusion was finally drawn that the floating sustained-release tablets possessing a good release property could be suitable for demands of design. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/25190152/Preparation_and_pharmacokinetics_study_on_gastro_floating_sustained_release_tablets_of_troxipide_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2014.956113 DB - PRIME DP - Unbound Medicine ER -