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Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients.
BMC Nephrol. 2014 Sep 04; 15:145.BN

Abstract

BACKGROUND

Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last process being dependent on vitamin K. The present study focused on the inactive form of MGP (dephosphorylated and uncarboxylated: dp-ucMGP) in a population of hemodialyzed (HD) patients. Results found in subjects being treated or not with vitamin K antagonist (VKA) were compared and the relationship between dp-ucMGP levels and the vascular calcification score were assessed.

METHODS

One hundred sixty prevalent HD patients were enrolled into this observational cohort study, including 23 who were receiving VKA treatment. The calcification score was determined (using the Kauppila method) and dp-ucMGP levels were measured using the automated iSYS method.

RESULTS

dp-ucMGP levels were much higher in patients being treated with VKA and little overlap was found with those not being treated (5604 [3758; 7836] vs. 1939 [1419; 2841] pmol/L, p < 0.0001). In multivariate analysis, treatment with VKA was the most important variable explaining variation in dp-ucMGP levels even when adjusting for all other significant variables. In the 137 untreated patients, dp-ucMGP levels were significantly (p < 0.05) associated both in the uni- and multivariate analysis with age, body mass index, plasma levels of albumin, C-reactive protein, and FGF-23, and the vascular calcification score.

CONCLUSION

We confirmed that the concentration of dp-ucMGP was higher in HD patients being treated with VKA. We observed a significant correlation between dp-ucMGP concentration and the calcification score. Our data support the theoretical role of MGP in the development of vascular calcifications. We confirmed the potential role of the inactive form of MGP in assessing the vitamin K status of the HD patients.

TRIAL REGISTRATION

B707201215885.

Authors+Show Affiliations

Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium. pierre_delanaye@yahoo.fr.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

25190488

Citation

Delanaye, Pierre, et al. "Dephosphorylated-uncarboxylated Matrix Gla Protein Concentration Is Predictive of Vitamin K Status and Is Correlated With Vascular Calcification in a Cohort of Hemodialysis Patients." BMC Nephrology, vol. 15, 2014, p. 145.
Delanaye P, Krzesinski JM, Warling X, et al. Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients. BMC Nephrol. 2014;15:145.
Delanaye, P., Krzesinski, J. M., Warling, X., Moonen, M., Smelten, N., Médart, L., Pottel, H., & Cavalier, E. (2014). Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients. BMC Nephrology, 15, 145. https://doi.org/10.1186/1471-2369-15-145
Delanaye P, et al. Dephosphorylated-uncarboxylated Matrix Gla Protein Concentration Is Predictive of Vitamin K Status and Is Correlated With Vascular Calcification in a Cohort of Hemodialysis Patients. BMC Nephrol. 2014 Sep 4;15:145. PubMed PMID: 25190488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients. AU - Delanaye,Pierre, AU - Krzesinski,Jean-Marie, AU - Warling,Xavier, AU - Moonen,Martial, AU - Smelten,Nicole, AU - Médart,Laurent, AU - Pottel,Hans, AU - Cavalier,Etienne, Y1 - 2014/09/04/ PY - 2014/05/27/received PY - 2014/08/27/accepted PY - 2014/9/6/entrez PY - 2014/9/6/pubmed PY - 2015/3/31/medline SP - 145 EP - 145 JF - BMC nephrology JO - BMC Nephrol VL - 15 N2 - BACKGROUND: Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last process being dependent on vitamin K. The present study focused on the inactive form of MGP (dephosphorylated and uncarboxylated: dp-ucMGP) in a population of hemodialyzed (HD) patients. Results found in subjects being treated or not with vitamin K antagonist (VKA) were compared and the relationship between dp-ucMGP levels and the vascular calcification score were assessed. METHODS: One hundred sixty prevalent HD patients were enrolled into this observational cohort study, including 23 who were receiving VKA treatment. The calcification score was determined (using the Kauppila method) and dp-ucMGP levels were measured using the automated iSYS method. RESULTS: dp-ucMGP levels were much higher in patients being treated with VKA and little overlap was found with those not being treated (5604 [3758; 7836] vs. 1939 [1419; 2841] pmol/L, p < 0.0001). In multivariate analysis, treatment with VKA was the most important variable explaining variation in dp-ucMGP levels even when adjusting for all other significant variables. In the 137 untreated patients, dp-ucMGP levels were significantly (p < 0.05) associated both in the uni- and multivariate analysis with age, body mass index, plasma levels of albumin, C-reactive protein, and FGF-23, and the vascular calcification score. CONCLUSION: We confirmed that the concentration of dp-ucMGP was higher in HD patients being treated with VKA. We observed a significant correlation between dp-ucMGP concentration and the calcification score. Our data support the theoretical role of MGP in the development of vascular calcifications. We confirmed the potential role of the inactive form of MGP in assessing the vitamin K status of the HD patients. TRIAL REGISTRATION: B707201215885. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/25190488/Dephosphorylated_uncarboxylated_Matrix_Gla_protein_concentration_is_predictive_of_vitamin_K_status_and_is_correlated_with_vascular_calcification_in_a_cohort_of_hemodialysis_patients_ L2 - https://www.biomedcentral.com/1471-2369/15/145 DB - PRIME DP - Unbound Medicine ER -