Tags

Type your tag names separated by a space and hit enter

Effects of hydrolysed casein, intact casein and intact whey protein on energy expenditure and appetite regulation: a randomised, controlled, cross-over study.
Br J Nutr. 2014 Oct 28; 112(8):1412-22.BJ

Abstract

Casein and whey differ in amino acid composition and in the rate of absorption; however, the absorption rate of casein can be increased to mimic that of whey by exogenous hydrolysis. The objective of the present study was to compare the effects of hydrolysed casein (HC), intact casein (IC) and intact whey (IW) on energy expenditure (EE) and appetite regulation, and thereby to investigate the influence of amino acid composition and the rate of absorption. In the present randomised cross-over study, twenty-four overweight and moderately obese young men and women consumed three isoenergetic dietary treatments that varied in protein source. The study was conducted in a respiration chamber, where EE, substrate oxidation and subjective appetite were measured over 24 h at three independent visits. Moreover, blood and urine samples were collected from the participants. The results showed no differences in 24 h and postprandial EE or appetite regulation. However, lipid oxidation, estimated from the respiratory quotient (RQ), was found to be higher after consumption of IW than after consumption of HC during daytime (P= 0·014) as well as during the time after the breakfast meal (P= 0·008) when the food was provided. Likewise, NEFA concentrations were found to be higher after consumption of IW than after consumption of HC and IC (P< 0·01). However, there was no overall difference in the concentration of insulin or glucagon-like peptide 1. In conclusion, dietary treatments when served as high-protein mixed meals induced similar effects on EE and appetite regulation, except for lipid oxidation, where RQ values suggest that it is higher after consumption of IW than after consumption of HC.

Authors+Show Affiliations

Department of Nutrition, Exercise and Sports,Faculty of Science, University of Copenhagen, Rolighedsvej 30,DK-1958Frederiksberg C, Copenhagen,Denmark.Department of Nutrition, Exercise and Sports,Faculty of Science, University of Copenhagen, Rolighedsvej 30,DK-1958Frederiksberg C, Copenhagen,Denmark.Department of Nutrition, Exercise and Sports,Faculty of Science, University of Copenhagen, Rolighedsvej 30,DK-1958Frederiksberg C, Copenhagen,Denmark.National Institute of Nutrition and Seafood Research,Bergen,Norway.Department of Biomedical Sciences,The NNF Center for Basic Metabolism Research, University of Copenhagen,Copenhagen,Denmark.Department of Nutrition, Exercise and Sports,Faculty of Science, University of Copenhagen, Rolighedsvej 30,DK-1958Frederiksberg C, Copenhagen,Denmark.Institute of Sports Medicine, Bispebjerg Hospital,Copenhagen,Denmark.Department of Nutrition, Exercise and Sports,Faculty of Science, University of Copenhagen, Rolighedsvej 30,DK-1958Frederiksberg C, Copenhagen,Denmark.Department of Nutrition, Exercise and Sports,Faculty of Science, University of Copenhagen, Rolighedsvej 30,DK-1958Frederiksberg C, Copenhagen,Denmark.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25191896

Citation

Bendtsen, Line Q., et al. "Effects of Hydrolysed Casein, Intact Casein and Intact Whey Protein On Energy Expenditure and Appetite Regulation: a Randomised, Controlled, Cross-over Study." The British Journal of Nutrition, vol. 112, no. 8, 2014, pp. 1412-22.
Bendtsen LQ, Lorenzen JK, Gomes S, et al. Effects of hydrolysed casein, intact casein and intact whey protein on energy expenditure and appetite regulation: a randomised, controlled, cross-over study. Br J Nutr. 2014;112(8):1412-22.
Bendtsen, L. Q., Lorenzen, J. K., Gomes, S., Liaset, B., Holst, J. J., Ritz, C., Reitelseder, S., Sjödin, A., & Astrup, A. (2014). Effects of hydrolysed casein, intact casein and intact whey protein on energy expenditure and appetite regulation: a randomised, controlled, cross-over study. The British Journal of Nutrition, 112(8), 1412-22. https://doi.org/10.1017/S000711451400213X
Bendtsen LQ, et al. Effects of Hydrolysed Casein, Intact Casein and Intact Whey Protein On Energy Expenditure and Appetite Regulation: a Randomised, Controlled, Cross-over Study. Br J Nutr. 2014 Oct 28;112(8):1412-22. PubMed PMID: 25191896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hydrolysed casein, intact casein and intact whey protein on energy expenditure and appetite regulation: a randomised, controlled, cross-over study. AU - Bendtsen,Line Q, AU - Lorenzen,Janne K, AU - Gomes,Sisse, AU - Liaset,Bjørn, AU - Holst,Jens J, AU - Ritz,Christian, AU - Reitelseder,Søren, AU - Sjödin,Anders, AU - Astrup,Arne, Y1 - 2014/09/05/ PY - 2014/9/6/entrez PY - 2014/9/6/pubmed PY - 2014/12/17/medline SP - 1412 EP - 22 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 112 IS - 8 N2 - Casein and whey differ in amino acid composition and in the rate of absorption; however, the absorption rate of casein can be increased to mimic that of whey by exogenous hydrolysis. The objective of the present study was to compare the effects of hydrolysed casein (HC), intact casein (IC) and intact whey (IW) on energy expenditure (EE) and appetite regulation, and thereby to investigate the influence of amino acid composition and the rate of absorption. In the present randomised cross-over study, twenty-four overweight and moderately obese young men and women consumed three isoenergetic dietary treatments that varied in protein source. The study was conducted in a respiration chamber, where EE, substrate oxidation and subjective appetite were measured over 24 h at three independent visits. Moreover, blood and urine samples were collected from the participants. The results showed no differences in 24 h and postprandial EE or appetite regulation. However, lipid oxidation, estimated from the respiratory quotient (RQ), was found to be higher after consumption of IW than after consumption of HC during daytime (P= 0·014) as well as during the time after the breakfast meal (P= 0·008) when the food was provided. Likewise, NEFA concentrations were found to be higher after consumption of IW than after consumption of HC and IC (P< 0·01). However, there was no overall difference in the concentration of insulin or glucagon-like peptide 1. In conclusion, dietary treatments when served as high-protein mixed meals induced similar effects on EE and appetite regulation, except for lipid oxidation, where RQ values suggest that it is higher after consumption of IW than after consumption of HC. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25191896/Effects_of_hydrolysed_casein_intact_casein_and_intact_whey_protein_on_energy_expenditure_and_appetite_regulation:_a_randomised_controlled_cross_over_study_ DB - PRIME DP - Unbound Medicine ER -