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The role of the central histaminergic receptors in the exercise-induced improvements of the spatial learning and memory in rats.
Brain Res. 2014 Oct 31; 1587:112-8.BR

Abstract

While it is well known that exercise can improve cognitive performance, the underlying mechanisms are not fully understood. There is now evidence that histamine can modulate learning and memory in different types of behavioral tasks. The present study was designed to examine the possible role of central histamine H1 and H2 receptors in forced treadmill running-induced enhancement of learning and memory in rats. For this purpose the animals received intracerebroventricularly chlorpheniramine (H1 receptor blocker) and cimetidine (H2 receptor blocker) before each day of fifteen consecutive days of exercise. Then their learning and memory were tested on the water maze task using a four-trial-per-day for 4 consecutive days. A probe trial was performed after the last training day. Our data showed that cimetidine reversed the exercise-induced improvement in learning and memory in rats; however, this was not the case regarding chlorpheniramine. Our findings indicate that central histamine H2 receptors play an important role in mediating the beneficial effects of forced exercise on learning and memory.

Authors+Show Affiliations

Faculty of Veterinary Medicine, Lorestan University, Khoramabad, Iran. Electronic address: Taatimajid@yahoo.com.Lorestan University of Medical Sciences, Khoramabad, Iran.Faculty of Sciences, Azad University, Hamedan, Iran.Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran.Faculty of Veterinary Medicine, Lorestan University, Khoramabad, Iran.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25192644

Citation

Taati, Majid, et al. "The Role of the Central Histaminergic Receptors in the Exercise-induced Improvements of the Spatial Learning and Memory in Rats." Brain Research, vol. 1587, 2014, pp. 112-8.
Taati M, Moghaddasi M, Esmaeili M, et al. The role of the central histaminergic receptors in the exercise-induced improvements of the spatial learning and memory in rats. Brain Res. 2014;1587:112-8.
Taati, M., Moghaddasi, M., Esmaeili, M., Pourkhodadad, S., & Nayebzadeh, H. (2014). The role of the central histaminergic receptors in the exercise-induced improvements of the spatial learning and memory in rats. Brain Research, 1587, 112-8. https://doi.org/10.1016/j.brainres.2014.08.065
Taati M, et al. The Role of the Central Histaminergic Receptors in the Exercise-induced Improvements of the Spatial Learning and Memory in Rats. Brain Res. 2014 Oct 31;1587:112-8. PubMed PMID: 25192644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the central histaminergic receptors in the exercise-induced improvements of the spatial learning and memory in rats. AU - Taati,Majid, AU - Moghaddasi,Mehrnoush, AU - Esmaeili,Masoumeh, AU - Pourkhodadad,Soheila, AU - Nayebzadeh,Hassan, Y1 - 2014/09/01/ PY - 2014/05/17/received PY - 2014/08/02/revised PY - 2014/08/23/accepted PY - 2014/9/7/entrez PY - 2014/9/7/pubmed PY - 2015/7/18/medline KW - Exercise KW - Histaminergic receptors KW - Spatial learning KW - Spatial memory SP - 112 EP - 8 JF - Brain research JO - Brain Res VL - 1587 N2 - While it is well known that exercise can improve cognitive performance, the underlying mechanisms are not fully understood. There is now evidence that histamine can modulate learning and memory in different types of behavioral tasks. The present study was designed to examine the possible role of central histamine H1 and H2 receptors in forced treadmill running-induced enhancement of learning and memory in rats. For this purpose the animals received intracerebroventricularly chlorpheniramine (H1 receptor blocker) and cimetidine (H2 receptor blocker) before each day of fifteen consecutive days of exercise. Then their learning and memory were tested on the water maze task using a four-trial-per-day for 4 consecutive days. A probe trial was performed after the last training day. Our data showed that cimetidine reversed the exercise-induced improvement in learning and memory in rats; however, this was not the case regarding chlorpheniramine. Our findings indicate that central histamine H2 receptors play an important role in mediating the beneficial effects of forced exercise on learning and memory. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/25192644/The_role_of_the_central_histaminergic_receptors_in_the_exercise_induced_improvements_of_the_spatial_learning_and_memory_in_rats_ DB - PRIME DP - Unbound Medicine ER -