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Primary syphilis of the oropharynx: an unusual location of a chancre.
Int J STD AIDS. 2015 Aug; 26(9):679-81.IJ

Abstract

A 33-year-old man presented with a two-week history of an asymptomatic ulcer of the oropharynx and submandibular lymph nodes swelling. Laboratory examinations were normal, but serological tests revealed positivity for rapid plasma reagin, Treponema pallidum haemagglutination assay and anti-T. pallidum IgM antibodies. Since the patient denied any homosexual relationship, a biopsy of the lesion was performed, which confirmed primary syphilis. The patient received an intramuscular injection of Benzathine Penicillin G (2.4 MU) with complete resolution of the lesion. Extragenital chancres occur in at least 5% of patients with primary syphilis, and the oral mucosa is the most frequent location as a consequence of orogenital/oroanal contact with an infectious lesion. Because of their transient nature, these oral ulcerations are often underestimated by the patient or by any unsuspecting clinician. Health professionals should consider the recent sexual history of their patients and should be prepared to recognise oral and systemic manifestations of sexually transmitted infections.

Authors+Show Affiliations

DISSAL, Department of Dermatology, IRCCS A.O.U. San Martino-IST, Genoa, Italy.DISSAL, Department of Dermatology, IRCCS A.O.U. San Martino-IST, Genoa, Italy giuliaciccarese@libero.it.DISSAL, Department of Dermatology, IRCCS A.O.U. San Martino-IST, Genoa, Italy.Dermatopathology Section, Azienda Ospedaliera Città della Salute e della Scienza, Turin, Italy.DISSAL, Department of Dermatology, IRCCS A.O.U. San Martino-IST, Genoa, Italy.DISSAL, Department of Dermatology, IRCCS A.O.U. San Martino-IST, Genoa, Italy.DISSAL, Department of Dermatology, IRCCS A.O.U. San Martino-IST, Genoa, Italy.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25193247

Citation

Drago, Francesco, et al. "Primary Syphilis of the Oropharynx: an Unusual Location of a Chancre." International Journal of STD & AIDS, vol. 26, no. 9, 2015, pp. 679-81.
Drago F, Ciccarese G, Cogorno L, et al. Primary syphilis of the oropharynx: an unusual location of a chancre. Int J STD AIDS. 2015;26(9):679-81.
Drago, F., Ciccarese, G., Cogorno, L., Tomasini, C. F., Cozzani, E. C., Riva, S. F., & Parodi, A. (2015). Primary syphilis of the oropharynx: an unusual location of a chancre. International Journal of STD & AIDS, 26(9), 679-81. https://doi.org/10.1177/0956462414551235
Drago F, et al. Primary Syphilis of the Oropharynx: an Unusual Location of a Chancre. Int J STD AIDS. 2015;26(9):679-81. PubMed PMID: 25193247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary syphilis of the oropharynx: an unusual location of a chancre. AU - Drago,Francesco, AU - Ciccarese,Giulia, AU - Cogorno,Ludovica, AU - Tomasini,Carlo F, AU - Cozzani,Emanuele C, AU - Riva,Silvia F, AU - Parodi,Aurora, Y1 - 2014/09/04/ PY - 2014/06/17/received PY - 2014/08/14/accepted PY - 2014/9/7/entrez PY - 2014/9/7/pubmed PY - 2016/5/19/medline KW - Treponema pallidum KW - extragenital chancres KW - oral ulcerations KW - primary syphilis KW - sexually transmitted infection SP - 679 EP - 81 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 26 IS - 9 N2 - A 33-year-old man presented with a two-week history of an asymptomatic ulcer of the oropharynx and submandibular lymph nodes swelling. Laboratory examinations were normal, but serological tests revealed positivity for rapid plasma reagin, Treponema pallidum haemagglutination assay and anti-T. pallidum IgM antibodies. Since the patient denied any homosexual relationship, a biopsy of the lesion was performed, which confirmed primary syphilis. The patient received an intramuscular injection of Benzathine Penicillin G (2.4 MU) with complete resolution of the lesion. Extragenital chancres occur in at least 5% of patients with primary syphilis, and the oral mucosa is the most frequent location as a consequence of orogenital/oroanal contact with an infectious lesion. Because of their transient nature, these oral ulcerations are often underestimated by the patient or by any unsuspecting clinician. Health professionals should consider the recent sexual history of their patients and should be prepared to recognise oral and systemic manifestations of sexually transmitted infections. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/25193247/Primary_syphilis_of_the_oropharynx:_an_unusual_location_of_a_chancre_ L2 - https://journals.sagepub.com/doi/10.1177/0956462414551235?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -