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Test meals rich in marine long-chain n-3 polyunsaturated fatty acids increase postprandial chylomicron response.
Nutr Res 2014; 34(8):661-6NR

Abstract

Postprandial lipid abnormalities are considered an independent cardiovascular risk factor. Hence, it is important to find nutritional strategies that are able to positively influence these abnormalities. Since the effect of n-3 polyunsaturated fatty acids (PUFA) and polyphenols on postprandial lipids in humans is still under debate, we evaluated the acute response of triglyceride-rich lipoproteins to test meals that are naturally rich in polyphenols and/or marine long-chain (LC) n-3 PUFAs. We hypothesized that LC n-3 PUFA would have a different effect on chylomicron and very low density lipoproteins when compared with polyphenols or their combination. We randomly assigned 78 individuals who were at high cardiometabolic risk to 4 isoenergetic diets. These diets only differed in amount of LC n-3 PUFA and/or polyphenols. Prior to starting the intervention, each subject underwent a test meal similar to the type of diet assigned: low in LC n-3 PUFA and polyphenols (control), rich in LC n-3 PUFA and low in polyphenols, rich in polyphenols and low in LC n-3 PUFA, or rich in both. Blood samples were taken before and up to 6 hours after the test meal in order to evaluate cholesterol and triglycerides (plasma and triglyceride-rich lipoprotein), apolipoprotein B-48 (large very low density lipoprotein), glucagon-like peptide-1, and free fatty acid plasma levels. The levels of chylomicron cholesterol and triglyceride in response to the test meal rich in LC n-3 PUFA were significantly higher than after the control meal (P = .037 and P = .018); there was no difference in the other variables. In conclusion, this study indicates that acute administration of marine LC n-3 PUFA increases postprandial chylomicron response in contrast with their lowering chronic effects. These differences underline the importance of understanding the acute and chronic effects of nutritional, as well as of other types of, interventions.

Authors+Show Affiliations

Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. Electronic address: rivelles@unina.it.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25193793

Citation

Griffo, E, et al. "Test Meals Rich in Marine Long-chain N-3 Polyunsaturated Fatty Acids Increase Postprandial Chylomicron Response." Nutrition Research (New York, N.Y.), vol. 34, no. 8, 2014, pp. 661-6.
Griffo E, Di Marino L, Patti L, et al. Test meals rich in marine long-chain n-3 polyunsaturated fatty acids increase postprandial chylomicron response. Nutr Res. 2014;34(8):661-6.
Griffo, E., Di Marino, L., Patti, L., Bozzetto, L., Annuzzi, G., Cipriano, P., ... Rivellese, A. A. (2014). Test meals rich in marine long-chain n-3 polyunsaturated fatty acids increase postprandial chylomicron response. Nutrition Research (New York, N.Y.), 34(8), pp. 661-6. doi:10.1016/j.nutres.2014.07.005.
Griffo E, et al. Test Meals Rich in Marine Long-chain N-3 Polyunsaturated Fatty Acids Increase Postprandial Chylomicron Response. Nutr Res. 2014;34(8):661-6. PubMed PMID: 25193793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Test meals rich in marine long-chain n-3 polyunsaturated fatty acids increase postprandial chylomicron response. AU - Griffo,E, AU - Di Marino,L, AU - Patti,L, AU - Bozzetto,L, AU - Annuzzi,G, AU - Cipriano,P, AU - Mangione,A, AU - Della Pepa,G, AU - Cocozza,S, AU - Riccardi,G, AU - Rivellese,A A, Y1 - 2014/07/10/ PY - 2014/02/25/received PY - 2014/06/20/revised PY - 2014/07/03/accepted PY - 2014/9/7/entrez PY - 2014/9/7/pubmed PY - 2015/5/12/medline KW - GLP-1 KW - High-risk subjects KW - Long-chain n-3 polyunsaturated fatty acids KW - Polyphenols KW - Postprandial lipid response SP - 661 EP - 6 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 34 IS - 8 N2 - Postprandial lipid abnormalities are considered an independent cardiovascular risk factor. Hence, it is important to find nutritional strategies that are able to positively influence these abnormalities. Since the effect of n-3 polyunsaturated fatty acids (PUFA) and polyphenols on postprandial lipids in humans is still under debate, we evaluated the acute response of triglyceride-rich lipoproteins to test meals that are naturally rich in polyphenols and/or marine long-chain (LC) n-3 PUFAs. We hypothesized that LC n-3 PUFA would have a different effect on chylomicron and very low density lipoproteins when compared with polyphenols or their combination. We randomly assigned 78 individuals who were at high cardiometabolic risk to 4 isoenergetic diets. These diets only differed in amount of LC n-3 PUFA and/or polyphenols. Prior to starting the intervention, each subject underwent a test meal similar to the type of diet assigned: low in LC n-3 PUFA and polyphenols (control), rich in LC n-3 PUFA and low in polyphenols, rich in polyphenols and low in LC n-3 PUFA, or rich in both. Blood samples were taken before and up to 6 hours after the test meal in order to evaluate cholesterol and triglycerides (plasma and triglyceride-rich lipoprotein), apolipoprotein B-48 (large very low density lipoprotein), glucagon-like peptide-1, and free fatty acid plasma levels. The levels of chylomicron cholesterol and triglyceride in response to the test meal rich in LC n-3 PUFA were significantly higher than after the control meal (P = .037 and P = .018); there was no difference in the other variables. In conclusion, this study indicates that acute administration of marine LC n-3 PUFA increases postprandial chylomicron response in contrast with their lowering chronic effects. These differences underline the importance of understanding the acute and chronic effects of nutritional, as well as of other types of, interventions. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/25193793/Test_meals_rich_in_marine_long_chain_n_3_polyunsaturated_fatty_acids_increase_postprandial_chylomicron_response_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(14)00109-2 DB - PRIME DP - Unbound Medicine ER -