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Tea consumption and lung cancer risk: a meta-analysis of case-control and cohort studies.

Abstract

OBJECTIVE

Recent epidemiologic studies, especially cohort and case-control studies, have yielded inconsistent findings regarding the association between tea consumption and risk for lung cancer. The aim of this study was to assess a potential relationship between tea consumption and the incidence of lung cancer worldwide.

METHODS

A systematic literature search of PubMed, Web of Science, the Cochrane Library, Google Scholar, the Chinese Biomedical Database, and Wanfang Database was conducted from 1966 to January 2014 by two investigators. All cohort studies and case-control studies that evaluated the association of tea and lung cancer were included. Summary relative risks (RR) and the corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. Quality assessments were performed using the Newcastle-Ottawa Scale. Heterogeneity was assessed using the Q and I(2) tests, and the source of heterogeneity was detected by meta-regression analysis. Publication bias was evaluated with Egger's regression symmetry test. Subgroup analyses and sensitivity analysis were performed.

RESULTS

Thirty-eight lung cancer studies (26 case-control studies and 12 cohort studies) with 59,041 cases and 396,664 controls were included. Overall tea consumption was significantly associated with decreased risk for lung cancer (RR, 0.78; 95% CI, 0.70-0.87). Subgroup analyses showed that tea consumption was associated with reduced risk for lung cancer in women (RR, 0.76; 95% CI, 0.62-0.93), case-control studies (RR 0.72; 95% CI 0.63-0.83), Western studies (RR, 0.85; 95% CI, 0.75-0.97), and studies in China and Japan (RR, 0.74; 95% CI, 0.62-0.88). Both green tea (RR, 0.75; 95% CI, 0.62-0.91) and black tea (RR, 0.82; 95% CI, 0.71-0.94) were significantly associated with reduced lung cancer risk. No significant association was found in men or in cohort studies.

CONCLUSION

Tea consumption may offer some protection against lung cancer.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Nutrition and Healthy Food, Tongji University School of Medicine, Shanghai, China. Electronic address: Lanfangwlf@tongji.edu.cn.

    ,

    Institute of Nutrition and Healthy Food, Tongji University School of Medicine, Shanghai, China.

    ,

    Institute of Nutrition and Healthy Food, Tongji University School of Medicine, Shanghai, China.

    ,

    Department of Pathogen Biology, Tongji University School of Medicine, Shanghai, China.

    Department of Preventive Medicine, Tongji University School of Medicine, Shanghai, China.

    Source

    MeSH

    Camellia sinensis
    Humans
    Lung Neoplasms
    Plant Preparations
    Risk
    Tea

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25194612

    Citation

    Wang, Lanfang, et al. "Tea Consumption and Lung Cancer Risk: a Meta-analysis of Case-control and Cohort Studies." Nutrition (Burbank, Los Angeles County, Calif.), vol. 30, no. 10, 2014, pp. 1122-7.
    Wang L, Zhang X, Liu J, et al. Tea consumption and lung cancer risk: a meta-analysis of case-control and cohort studies. Nutrition. 2014;30(10):1122-7.
    Wang, L., Zhang, X., Liu, J., Shen, L., & Li, Z. (2014). Tea consumption and lung cancer risk: a meta-analysis of case-control and cohort studies. Nutrition (Burbank, Los Angeles County, Calif.), 30(10), pp. 1122-7. doi:10.1016/j.nut.2014.02.023.
    Wang L, et al. Tea Consumption and Lung Cancer Risk: a Meta-analysis of Case-control and Cohort Studies. Nutrition. 2014;30(10):1122-7. PubMed PMID: 25194612.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Tea consumption and lung cancer risk: a meta-analysis of case-control and cohort studies. AU - Wang,Lanfang, AU - Zhang,Xingwei, AU - Liu,Jing, AU - Shen,Li, AU - Li,Zhiqiang, Y1 - 2014/03/12/ PY - 2013/09/24/received PY - 2014/02/20/revised PY - 2014/02/25/accepted PY - 2014/9/8/entrez PY - 2014/9/10/pubmed PY - 2015/5/13/medline KW - Lung cancer KW - Meta-analysis KW - Tea SP - 1122 EP - 7 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 30 IS - 10 N2 - OBJECTIVE: Recent epidemiologic studies, especially cohort and case-control studies, have yielded inconsistent findings regarding the association between tea consumption and risk for lung cancer. The aim of this study was to assess a potential relationship between tea consumption and the incidence of lung cancer worldwide. METHODS: A systematic literature search of PubMed, Web of Science, the Cochrane Library, Google Scholar, the Chinese Biomedical Database, and Wanfang Database was conducted from 1966 to January 2014 by two investigators. All cohort studies and case-control studies that evaluated the association of tea and lung cancer were included. Summary relative risks (RR) and the corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. Quality assessments were performed using the Newcastle-Ottawa Scale. Heterogeneity was assessed using the Q and I(2) tests, and the source of heterogeneity was detected by meta-regression analysis. Publication bias was evaluated with Egger's regression symmetry test. Subgroup analyses and sensitivity analysis were performed. RESULTS: Thirty-eight lung cancer studies (26 case-control studies and 12 cohort studies) with 59,041 cases and 396,664 controls were included. Overall tea consumption was significantly associated with decreased risk for lung cancer (RR, 0.78; 95% CI, 0.70-0.87). Subgroup analyses showed that tea consumption was associated with reduced risk for lung cancer in women (RR, 0.76; 95% CI, 0.62-0.93), case-control studies (RR 0.72; 95% CI 0.63-0.83), Western studies (RR, 0.85; 95% CI, 0.75-0.97), and studies in China and Japan (RR, 0.74; 95% CI, 0.62-0.88). Both green tea (RR, 0.75; 95% CI, 0.62-0.91) and black tea (RR, 0.82; 95% CI, 0.71-0.94) were significantly associated with reduced lung cancer risk. No significant association was found in men or in cohort studies. CONCLUSION: Tea consumption may offer some protection against lung cancer. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25194612/Tea_consumption_and_lung_cancer_risk:_a_meta_analysis_of_case_control_and_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(14)00128-2 DB - PRIME DP - Unbound Medicine ER -