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Association between fruit and vegetable intake and risk for glioma: a meta-analysis.

Abstract

OBJECTIVE

Epidemiologic studies evaluating the association between the intake of vegetables and fruit and the risk for glioma have produced inconsistent results. Therefore, the aim of this study was to test the hypothesis that higher vegetable and fruit intake may have a protective effect on risk for glioma.

METHODS

Pertinent studies were identified by a search in PubMed, Web of Knowledge, and Wan Fang Med Online up to January 2014. Random-effect model was used to combine study-specific results. Publication bias was estimated using Begg's funnel plot and Egger's regression asymmetry test.

RESULTS

Fifteen studies involving 5562 cases focusing on vegetable intake and 17 studies involving 3994 cases of fruit intake compared with the risk for glioma were included in this meta-analysis. The combined relative risk (RR) of glioma associated with vegetable intake was 0.775 (95% confidence interval [CI], 0.688-0.872) overall, and the association for subgroup analysis by study design, sources of control, ethnicity, and number of cases was consistent with overall data. For fruit intake and glioma risk, significant protective associations were found in an Asian population (RR, 0.573; 95% CI, 0.346-0.947), but not in a white population. No publication bias was found.

CONCLUSIONS

This analysis indicated that intake of vegetables might have a protective effect on glioma. The intake of fruit might have a protective effect on glioma in the Asian population; however, the results need to be confirmed.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: Chty11927@163.com.

    Source

    MeSH

    Asian Continental Ancestry Group
    Diet
    European Continental Ancestry Group
    Feeding Behavior
    Fruit
    Glioma
    Humans
    Vegetables

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    25194962

    Citation

    Li, Ying. "Association Between Fruit and Vegetable Intake and Risk for Glioma: a Meta-analysis." Nutrition (Burbank, Los Angeles County, Calif.), vol. 30, no. 11-12, 2014, pp. 1272-8.
    Li Y. Association between fruit and vegetable intake and risk for glioma: a meta-analysis. Nutrition. 2014;30(11-12):1272-8.
    Li, Y. (2014). Association between fruit and vegetable intake and risk for glioma: a meta-analysis. Nutrition (Burbank, Los Angeles County, Calif.), 30(11-12), pp. 1272-8. doi:10.1016/j.nut.2014.03.027.
    Li Y. Association Between Fruit and Vegetable Intake and Risk for Glioma: a Meta-analysis. Nutrition. 2014;30(11-12):1272-8. PubMed PMID: 25194962.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between fruit and vegetable intake and risk for glioma: a meta-analysis. A1 - Li,Ying, Y1 - 2014/04/13/ PY - 2014/03/02/received PY - 2014/03/29/revised PY - 2014/03/31/accepted PY - 2014/9/8/entrez PY - 2014/9/10/pubmed PY - 2015/6/2/medline KW - Fruit KW - Glioma KW - Meta-analysis KW - Vegetables SP - 1272 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 30 IS - 11-12 N2 - OBJECTIVE: Epidemiologic studies evaluating the association between the intake of vegetables and fruit and the risk for glioma have produced inconsistent results. Therefore, the aim of this study was to test the hypothesis that higher vegetable and fruit intake may have a protective effect on risk for glioma. METHODS: Pertinent studies were identified by a search in PubMed, Web of Knowledge, and Wan Fang Med Online up to January 2014. Random-effect model was used to combine study-specific results. Publication bias was estimated using Begg's funnel plot and Egger's regression asymmetry test. RESULTS: Fifteen studies involving 5562 cases focusing on vegetable intake and 17 studies involving 3994 cases of fruit intake compared with the risk for glioma were included in this meta-analysis. The combined relative risk (RR) of glioma associated with vegetable intake was 0.775 (95% confidence interval [CI], 0.688-0.872) overall, and the association for subgroup analysis by study design, sources of control, ethnicity, and number of cases was consistent with overall data. For fruit intake and glioma risk, significant protective associations were found in an Asian population (RR, 0.573; 95% CI, 0.346-0.947), but not in a white population. No publication bias was found. CONCLUSIONS: This analysis indicated that intake of vegetables might have a protective effect on glioma. The intake of fruit might have a protective effect on glioma in the Asian population; however, the results need to be confirmed. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25194962/Association_between_fruit_and_vegetable_intake_and_risk_for_glioma:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(14)00189-0 DB - PRIME DP - Unbound Medicine ER -