Tags

Type your tag names separated by a space and hit enter

Magnetic/pH-sensitive κ-carrageenan/sodium alginate hydrogel nanocomposite beads: preparation, swelling behavior, and drug delivery.
J Biomater Sci Polym Ed. 2014; 25(17):1891-906.JB

Abstract

This work describes the preparation of magnetic and pH-sensitive beads based on κ-carrageenan and sodium alginate for use as drug-targeting carriers. Physical cross-linking using K(+)/Ca(2+) ions was applied to obtain ionic cross-linked magnetic hydrogel beads. The produced magnetite beads were thoroughly characterized by TEM, SEM/EDS, XRD, FTIR, and VSM techniques. While the water absorbency (WA) of magnetic beads was enhanced by increasing the weight ratio of κ-carrageenan, introducing magnetic nanoparticles caused a decrease in WA capacity from 15.4 to 6.3 g/g. Investigation on the swelling of the hydrogel beads in NaCl, KCl, and CaCl2 solutions revealed the disintegration of beads depending on the composition of hydrogel beads and the type of metal cations in swelling media. The swelling ratio of beads indicated pH-dependent properties with maximum water absorbing at pH 7.4. Also, it was found that the strength of pH-sensitivity of magnetic beads was low for beads with the high content of carrageenan component. The in vitro drug release studies from hydrogels exhibited significant behaviors on the subject of physiological-simulated pH values and external magnetic fields. The maximum cumulative releases obtained were 98 and 43% at pH values 7.4 and 1.2, respectively. The Introducing magnetite nanoparticles influenced the cumulative release of drug.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Mahdavinia GR
a Faculty of Science, Department of Chemistry , University of Maragheh , Maragheh 55181-83111 , Iran.
Rahmani Z
No affiliation info available
Karami S
No affiliation info available
Pourjavadi A
No affiliation info available

MeSH

AlginatesCarrageenanDrug CarriersDrug LiberationGlucuronic AcidHexuronic AcidsHydrogel, Polyethylene Glycol DimethacrylateHydrogen-Ion ConcentrationMagnetic FieldsMagnetite NanoparticlesNanocompositesRiboflavin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25197770

Citation

Mahdavinia, Gholam Reza, et al. "Magnetic/pH-sensitive Κ-carrageenan/sodium Alginate Hydrogel Nanocomposite Beads: Preparation, Swelling Behavior, and Drug Delivery." Journal of Biomaterials Science. Polymer Edition, vol. 25, no. 17, 2014, pp. 1891-906.
Mahdavinia GR, Rahmani Z, Karami S, et al. Magnetic/pH-sensitive κ-carrageenan/sodium alginate hydrogel nanocomposite beads: preparation, swelling behavior, and drug delivery. J Biomater Sci Polym Ed. 2014;25(17):1891-906.
Mahdavinia, G. R., Rahmani, Z., Karami, S., & Pourjavadi, A. (2014). Magnetic/pH-sensitive κ-carrageenan/sodium alginate hydrogel nanocomposite beads: preparation, swelling behavior, and drug delivery. Journal of Biomaterials Science. Polymer Edition, 25(17), 1891-906. https://doi.org/10.1080/09205063.2014.956166
Mahdavinia GR, et al. Magnetic/pH-sensitive Κ-carrageenan/sodium Alginate Hydrogel Nanocomposite Beads: Preparation, Swelling Behavior, and Drug Delivery. J Biomater Sci Polym Ed. 2014;25(17):1891-906. PubMed PMID: 25197770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic/pH-sensitive κ-carrageenan/sodium alginate hydrogel nanocomposite beads: preparation, swelling behavior, and drug delivery. AU - Mahdavinia,Gholam Reza, AU - Rahmani,Zeinab, AU - Karami,Shiva, AU - Pourjavadi,Ali, Y1 - 2014/09/08/ PY - 2014/9/9/entrez PY - 2014/9/10/pubmed PY - 2015/6/27/medline KW - drug delivery KW - magnetic beads KW - pH-sensitive KW - sodium alginate KW - κ-carrageenan SP - 1891 EP - 906 JF - Journal of biomaterials science. Polymer edition JO - J Biomater Sci Polym Ed VL - 25 IS - 17 N2 - This work describes the preparation of magnetic and pH-sensitive beads based on κ-carrageenan and sodium alginate for use as drug-targeting carriers. Physical cross-linking using K(+)/Ca(2+) ions was applied to obtain ionic cross-linked magnetic hydrogel beads. The produced magnetite beads were thoroughly characterized by TEM, SEM/EDS, XRD, FTIR, and VSM techniques. While the water absorbency (WA) of magnetic beads was enhanced by increasing the weight ratio of κ-carrageenan, introducing magnetic nanoparticles caused a decrease in WA capacity from 15.4 to 6.3 g/g. Investigation on the swelling of the hydrogel beads in NaCl, KCl, and CaCl2 solutions revealed the disintegration of beads depending on the composition of hydrogel beads and the type of metal cations in swelling media. The swelling ratio of beads indicated pH-dependent properties with maximum water absorbing at pH 7.4. Also, it was found that the strength of pH-sensitivity of magnetic beads was low for beads with the high content of carrageenan component. The in vitro drug release studies from hydrogels exhibited significant behaviors on the subject of physiological-simulated pH values and external magnetic fields. The maximum cumulative releases obtained were 98 and 43% at pH values 7.4 and 1.2, respectively. The Introducing magnetite nanoparticles influenced the cumulative release of drug. SN - 1568-5624 UR - https://www.unboundmedicine.com/medline/citation/25197770/Magnetic/pH_sensitive_��_carrageenan/sodium_alginate_hydrogel_nanocomposite_beads:_preparation_swelling_behavior_and_drug_delivery_ DB - PRIME DP - Unbound Medicine ER -