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Low-carbohydrate diets and cardiovascular and total mortality in Japanese: a 29-year follow-up of NIPPON DATA80.
Br J Nutr. 2014 Sep 28; 112(6):916-24.BJ

Abstract

Long-term safety of consuming low-carbohydrate diets (LCD) in Asian populations, whose carbohydrate intake is relatively high, is not known. In the present study, the association of LCD with CVD and total mortality was assessed using data obtained in the NIPPON DATA80 (National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged 1980) during 29 years of follow-up. At baseline in 1980, data were collected from study participants aged ≥ 30 years from randomly selected areas in Japan. LCD scores were calculated based on the percentage of energy as carbohydrate, fat and protein, estimated by 3 d weighed food records. A total of 9200 participants (56% women, mean age 51 years) were followed up. During the follow-up, 1171 CVD deaths (52% in women) and 3443 total deaths (48% in women) occurred. The multivariable-adjusted hazard ratio (HR) for CVD mortality using the Cox model comparing the highest v. lowest deciles of LCD score was 0·60 (95% CI 0·38, 0·94; P(trend) = 0·021) for women and 0·78 (95% CI 0·58, 1·05; P(trend) = 0·079) for women and men combined; the HR for total mortality was 0·74 (95% CI 0·57, 0·95; P(trend) = 0·029) for women and 0·87 (95% CI 0·74, 1·02; P(trend) = 0·090) for women and men combined. None of the associations was statistically significant in men. No differential effects of animal-based and plant-fish-based LCD were observed. In conclusions, moderate diets lower in carbohydrate and higher in protein and fat are significantly inversely associated with CVD and total mortality in women.

Authors+Show Affiliations

Cardiovascular Epidemiology, Kyoto Women's University,35 Imakumano Kitahiyoshi-cho, Higashiyama-ku,Kyoto605-8501,Japan.Department of Health and Nutrition,University of Human Arts and Sciences,Saitama,Japan.Department of Preventive Medicine and Public Health,School of Medicine, Keio University,Tokyo,Japan.Department of Health Science,Shiga University of Medical Science,Otsu,Japan.Department of Health Science,Shiga University of Medical Science,Otsu,Japan.Department of Hygiene and Preventive Medicine,Fukushima Medical University,Fukushima,Japan.Tsuruga City University of Nursing,Tsuruga,Japan.Department of Health Science,Shiga University of Medical Science,Otsu,Japan.Department of Health Science,Shiga University of Medical Science,Otsu,Japan.Department of Health Science,Shiga University of Medical Science,Otsu,Japan.Department of Hygiene and Public Health,Teikyo University School of Medicine,Tokyo,Japan.Department of Health Science,Shiga University of Medical Science,Otsu,Japan.Research Center for Lifestyle-Related Diseases,Tokyo,Japan.Department of Health Science,Shiga University of Medical Science,Otsu,Japan.No affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25201302

Citation

Nakamura, Yasuyuki, et al. "Low-carbohydrate Diets and Cardiovascular and Total Mortality in Japanese: a 29-year Follow-up of NIPPON DATA80." The British Journal of Nutrition, vol. 112, no. 6, 2014, pp. 916-24.
Nakamura Y, Okuda N, Okamura T, et al. Low-carbohydrate diets and cardiovascular and total mortality in Japanese: a 29-year follow-up of NIPPON DATA80. Br J Nutr. 2014;112(6):916-24.
Nakamura, Y., Okuda, N., Okamura, T., Kadota, A., Miyagawa, N., Hayakawa, T., Kita, Y., Fujiyoshi, A., Nagai, M., Takashima, N., Ohkubo, T., Miura, K., Okayama, A., & Ueshima, H. (2014). Low-carbohydrate diets and cardiovascular and total mortality in Japanese: a 29-year follow-up of NIPPON DATA80. The British Journal of Nutrition, 112(6), 916-24. https://doi.org/10.1017/S0007114514001627
Nakamura Y, et al. Low-carbohydrate Diets and Cardiovascular and Total Mortality in Japanese: a 29-year Follow-up of NIPPON DATA80. Br J Nutr. 2014 Sep 28;112(6):916-24. PubMed PMID: 25201302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-carbohydrate diets and cardiovascular and total mortality in Japanese: a 29-year follow-up of NIPPON DATA80. AU - Nakamura,Yasuyuki, AU - Okuda,Nagako, AU - Okamura,Tomonori, AU - Kadota,Aya, AU - Miyagawa,Naoko, AU - Hayakawa,Takehito, AU - Kita,Yoshikuni, AU - Fujiyoshi,Akira, AU - Nagai,Masato, AU - Takashima,Naoyuki, AU - Ohkubo,Takayoshi, AU - Miura,Katsuyuki, AU - Okayama,Akira, AU - Ueshima,Hirotsugu, AU - ,, PY - 2014/9/10/entrez PY - 2014/9/10/pubmed PY - 2014/12/15/medline SP - 916 EP - 24 JF - The British journal of nutrition JO - Br J Nutr VL - 112 IS - 6 N2 - Long-term safety of consuming low-carbohydrate diets (LCD) in Asian populations, whose carbohydrate intake is relatively high, is not known. In the present study, the association of LCD with CVD and total mortality was assessed using data obtained in the NIPPON DATA80 (National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged 1980) during 29 years of follow-up. At baseline in 1980, data were collected from study participants aged ≥ 30 years from randomly selected areas in Japan. LCD scores were calculated based on the percentage of energy as carbohydrate, fat and protein, estimated by 3 d weighed food records. A total of 9200 participants (56% women, mean age 51 years) were followed up. During the follow-up, 1171 CVD deaths (52% in women) and 3443 total deaths (48% in women) occurred. The multivariable-adjusted hazard ratio (HR) for CVD mortality using the Cox model comparing the highest v. lowest deciles of LCD score was 0·60 (95% CI 0·38, 0·94; P(trend) = 0·021) for women and 0·78 (95% CI 0·58, 1·05; P(trend) = 0·079) for women and men combined; the HR for total mortality was 0·74 (95% CI 0·57, 0·95; P(trend) = 0·029) for women and 0·87 (95% CI 0·74, 1·02; P(trend) = 0·090) for women and men combined. None of the associations was statistically significant in men. No differential effects of animal-based and plant-fish-based LCD were observed. In conclusions, moderate diets lower in carbohydrate and higher in protein and fat are significantly inversely associated with CVD and total mortality in women. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25201302/Low_carbohydrate_diets_and_cardiovascular_and_total_mortality_in_Japanese:_a_29_year_follow_up_of_NIPPON_DATA80_ L2 - https://www.cambridge.org/core/product/identifier/S0007114514001627/type/journal_article DB - PRIME DP - Unbound Medicine ER -