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Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders.
Intern Med J. 2014 Sep; 44(9):911-5.IM

Abstract

Wernicke encephalopathy is an acute, reversible neuropsychiatric emergency due to thiamine deficiency. Urgent and adequate thiamine replacement is necessary to avoid death or progression to Korsakoff syndrome with largely irreversible brain damage. Wernicke Korsakoff syndrome refers to a condition where features of Wernicke encephalopathy are mixed with those of Korsakoff syndrome. Although thiamine is the cornerstone of treatment of Wernicke encephalopathy, there are no universally accepted guidelines with regard to its optimal dose, mode of administration, frequency of administration or duration of treatment. Currently, different dose recommendations are being made. We present recommendations for the assessment and treatment of Wernicke encephalopathy based on literature review and our clinical experience.

Authors+Show Affiliations

Northern Sydney Drug and Alcohol Service, Royal North Shore Hospital, Sydney, New South Wales, Australia.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25201422

Citation

Latt, N, and G Dore. "Thiamine in the Treatment of Wernicke Encephalopathy in Patients With Alcohol Use Disorders." Internal Medicine Journal, vol. 44, no. 9, 2014, pp. 911-5.
Latt N, Dore G. Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders. Intern Med J. 2014;44(9):911-5.
Latt, N., & Dore, G. (2014). Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders. Internal Medicine Journal, 44(9), 911-5. https://doi.org/10.1111/imj.12522
Latt N, Dore G. Thiamine in the Treatment of Wernicke Encephalopathy in Patients With Alcohol Use Disorders. Intern Med J. 2014;44(9):911-5. PubMed PMID: 25201422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders. AU - Latt,N, AU - Dore,G, PY - 2013/11/11/received PY - 2014/06/17/accepted PY - 2014/9/10/entrez PY - 2014/9/10/pubmed PY - 2015/5/28/medline KW - Wernicke encephalopathy KW - alcohol use disorder KW - thiamine SP - 911 EP - 5 JF - Internal medicine journal JO - Intern Med J VL - 44 IS - 9 N2 - Wernicke encephalopathy is an acute, reversible neuropsychiatric emergency due to thiamine deficiency. Urgent and adequate thiamine replacement is necessary to avoid death or progression to Korsakoff syndrome with largely irreversible brain damage. Wernicke Korsakoff syndrome refers to a condition where features of Wernicke encephalopathy are mixed with those of Korsakoff syndrome. Although thiamine is the cornerstone of treatment of Wernicke encephalopathy, there are no universally accepted guidelines with regard to its optimal dose, mode of administration, frequency of administration or duration of treatment. Currently, different dose recommendations are being made. We present recommendations for the assessment and treatment of Wernicke encephalopathy based on literature review and our clinical experience. SN - 1445-5994 UR - https://www.unboundmedicine.com/medline/citation/25201422/Thiamine_in_the_treatment_of_Wernicke_encephalopathy_in_patients_with_alcohol_use_disorders_ L2 - https://doi.org/10.1111/imj.12522 DB - PRIME DP - Unbound Medicine ER -