Tags

Type your tag names separated by a space and hit enter

The longitudinal association of the diurnal cortisol rhythm with internalizing and externalizing problems in pre-schoolers. The Generation R Study.
Psychoneuroendocrinology. 2014 Dec; 50:118-29.P

Abstract

BACKGROUND

Studies investigating the association between diurnal cortisol rhythm and behavioural problems in young children have yielded inconsistent results. We tested the hypothesis that variations in diurnal cortisol rhythm in pre-schoolers are already related to problem behaviour early in life with a cross-sectional and longitudinal design.

METHODS

This study was embedded in Generation R, a population-based cohort from foetal life onwards. Parents collected saliva samples from their infant at 5 moments during 1 day. In 322 infants aged 12-20 months, we determined the diurnal cortisol rhythm by calculating the area under the curve (AUC), the cortisol awakening response (CAR), and the diurnal slope. Problem behaviour was assessed at ages 1.5 and 3 years with the Child Behavior Checklist/1.5-5 years.

RESULTS

No cross-sectional associations between the cortisol composite measures and problem behaviour were found at 1.5 years. However, cortisol predicted change in internalizing problems as assessed from 1.5 to 3 years, but not change in externalizing problems. Children with higher AUC levels, flatter slopes and a more positive CAR at baseline were more likely to score higher on the Internalizing Problems scale (β per nmol/L AUC: 0.08, 95% CI: 0.00; 0.17, p=0.04; β per nmol/L/h slope: 0.57, 95% CI: 0.17; 0.98, p=0.006; β per nmol/L CAR: 0.04, 95% CI: 0.01; 0.08, p=0.02) at follow-up.

CONCLUSIONS

Variations in diurnal cortisol rhythm are associated with change in internalizing problems in pre-schoolers. The results suggest that variations in diurnal cortisol patterns early in life precede internalizing problems.

Authors+Show Affiliations

The Generation R Study Group, Erasmus MC-University Medical Center, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.The Generation R Study Group, Erasmus MC-University Medical Center, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.The Generation R Study Group, Erasmus MC-University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.Department of Child and Adolescent Psychiatry, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.Department of Child and Adolescent Psychiatry, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands. Electronic address: h.tiemeier@erasmusmc.nl.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25202831

Citation

Saridjan, Nathalie S., et al. "The Longitudinal Association of the Diurnal Cortisol Rhythm With Internalizing and Externalizing Problems in Pre-schoolers. the Generation R Study." Psychoneuroendocrinology, vol. 50, 2014, pp. 118-29.
Saridjan NS, Velders FP, Jaddoe VW, et al. The longitudinal association of the diurnal cortisol rhythm with internalizing and externalizing problems in pre-schoolers. The Generation R Study. Psychoneuroendocrinology. 2014;50:118-29.
Saridjan, N. S., Velders, F. P., Jaddoe, V. W., Hofman, A., Verhulst, F. C., & Tiemeier, H. (2014). The longitudinal association of the diurnal cortisol rhythm with internalizing and externalizing problems in pre-schoolers. The Generation R Study. Psychoneuroendocrinology, 50, 118-29. https://doi.org/10.1016/j.psyneuen.2014.08.008
Saridjan NS, et al. The Longitudinal Association of the Diurnal Cortisol Rhythm With Internalizing and Externalizing Problems in Pre-schoolers. the Generation R Study. Psychoneuroendocrinology. 2014;50:118-29. PubMed PMID: 25202831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The longitudinal association of the diurnal cortisol rhythm with internalizing and externalizing problems in pre-schoolers. The Generation R Study. AU - Saridjan,Nathalie S, AU - Velders,Fleur P, AU - Jaddoe,Vincent W V, AU - Hofman,Albert, AU - Verhulst,Frank C, AU - Tiemeier,Henning, Y1 - 2014/08/22/ PY - 2014/02/09/received PY - 2014/07/30/revised PY - 2014/08/02/accepted PY - 2014/9/10/entrez PY - 2014/9/10/pubmed PY - 2015/8/1/medline KW - Cohort KW - Cortisol KW - Diurnal rhythm KW - HPA axis KW - Infants KW - Longitudinal KW - Problem behaviour SP - 118 EP - 29 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 50 N2 - BACKGROUND: Studies investigating the association between diurnal cortisol rhythm and behavioural problems in young children have yielded inconsistent results. We tested the hypothesis that variations in diurnal cortisol rhythm in pre-schoolers are already related to problem behaviour early in life with a cross-sectional and longitudinal design. METHODS: This study was embedded in Generation R, a population-based cohort from foetal life onwards. Parents collected saliva samples from their infant at 5 moments during 1 day. In 322 infants aged 12-20 months, we determined the diurnal cortisol rhythm by calculating the area under the curve (AUC), the cortisol awakening response (CAR), and the diurnal slope. Problem behaviour was assessed at ages 1.5 and 3 years with the Child Behavior Checklist/1.5-5 years. RESULTS: No cross-sectional associations between the cortisol composite measures and problem behaviour were found at 1.5 years. However, cortisol predicted change in internalizing problems as assessed from 1.5 to 3 years, but not change in externalizing problems. Children with higher AUC levels, flatter slopes and a more positive CAR at baseline were more likely to score higher on the Internalizing Problems scale (β per nmol/L AUC: 0.08, 95% CI: 0.00; 0.17, p=0.04; β per nmol/L/h slope: 0.57, 95% CI: 0.17; 0.98, p=0.006; β per nmol/L CAR: 0.04, 95% CI: 0.01; 0.08, p=0.02) at follow-up. CONCLUSIONS: Variations in diurnal cortisol rhythm are associated with change in internalizing problems in pre-schoolers. The results suggest that variations in diurnal cortisol patterns early in life precede internalizing problems. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/25202831/The_longitudinal_association_of_the_diurnal_cortisol_rhythm_with_internalizing_and_externalizing_problems_in_pre_schoolers__The_Generation_R_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(14)00313-8 DB - PRIME DP - Unbound Medicine ER -