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Association between chemokine receptor 5 delta32 polymorphism and susceptibility to cancer: a meta-analysis.
J Recept Signal Transduct Res. 2015; 35(6):509-15.JR

Abstract

OBJECTIVE

To explore whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to cancer.

METHODS

A meta-analysis was conducted on the association between the CCR5-Δ32 polymorphism and cancer using (i) allele contrast and (ii) the dominant model.

RESULTS

Thirteen articles, including 16 comparative studies on a total of 3087 patients and 3735 controls, were included in the meta-analysis. These studies encompassed breast cancer (n = 3), bladder cancer (n = 3), cervical cancer (n = 2), pancreatic cancer (n = 2), prostate cancer (n = 2), head and neck cancer (n = 2), lymphoma (n = 1), gallbladder cancer (n = 1), skin cancer (n = 1) and mixed cancer (n = 1). The meta-analysis revealed an association between cancer and the CCR5-Δ32 allele (OR = 1.368, 95% CI = 1.064-1.758, p = 0.014), and stratification by ethnicity showed an association between the CCR5-Δ32 allele and cancer in Indians (OR = 2.480, 95% CI = 1.247-4.932, p = 0.010). The meta-analysis also revealed an association between breast cancer and the CCR5-Δ32 allele (OR = 1.689, 95% CI = 1.012-2.821, p = 0.045). However, allele contrast and the dominant model failed to reveal an association between the CCR5-Δ32 polymorphism and bladder cancer, cervical cancer, pancreatic cancer, prostate cancer, and head and neck cancer.

CONCLUSIONS

This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with susceptibility to cancer in Indians and is associated with breast cancer.

Authors+Show Affiliations

a Division of Rheumatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Korea.a Division of Rheumatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Korea.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25203595

Citation

Lee, Young Ho, and Gwan Gyu Song. "Association Between Chemokine Receptor 5 Delta32 Polymorphism and Susceptibility to Cancer: a Meta-analysis." Journal of Receptor and Signal Transduction Research, vol. 35, no. 6, 2015, pp. 509-15.
Lee YH, Song GG. Association between chemokine receptor 5 delta32 polymorphism and susceptibility to cancer: a meta-analysis. J Recept Signal Transduct Res. 2015;35(6):509-15.
Lee, Y. H., & Song, G. G. (2015). Association between chemokine receptor 5 delta32 polymorphism and susceptibility to cancer: a meta-analysis. Journal of Receptor and Signal Transduction Research, 35(6), 509-15. https://doi.org/10.3109/10799893.2014.960934
Lee YH, Song GG. Association Between Chemokine Receptor 5 Delta32 Polymorphism and Susceptibility to Cancer: a Meta-analysis. J Recept Signal Transduct Res. 2015;35(6):509-15. PubMed PMID: 25203595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between chemokine receptor 5 delta32 polymorphism and susceptibility to cancer: a meta-analysis. AU - Lee,Young Ho, AU - Song,Gwan Gyu, Y1 - 2014/09/09/ PY - 2014/9/10/entrez PY - 2014/9/10/pubmed PY - 2016/8/12/medline KW - CCR5 KW - Cancer KW - meta-analysis KW - polymorphism SP - 509 EP - 15 JF - Journal of receptor and signal transduction research JO - J. Recept. Signal Transduct. Res. VL - 35 IS - 6 N2 - OBJECTIVE: To explore whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to cancer. METHODS: A meta-analysis was conducted on the association between the CCR5-Δ32 polymorphism and cancer using (i) allele contrast and (ii) the dominant model. RESULTS: Thirteen articles, including 16 comparative studies on a total of 3087 patients and 3735 controls, were included in the meta-analysis. These studies encompassed breast cancer (n = 3), bladder cancer (n = 3), cervical cancer (n = 2), pancreatic cancer (n = 2), prostate cancer (n = 2), head and neck cancer (n = 2), lymphoma (n = 1), gallbladder cancer (n = 1), skin cancer (n = 1) and mixed cancer (n = 1). The meta-analysis revealed an association between cancer and the CCR5-Δ32 allele (OR = 1.368, 95% CI = 1.064-1.758, p = 0.014), and stratification by ethnicity showed an association between the CCR5-Δ32 allele and cancer in Indians (OR = 2.480, 95% CI = 1.247-4.932, p = 0.010). The meta-analysis also revealed an association between breast cancer and the CCR5-Δ32 allele (OR = 1.689, 95% CI = 1.012-2.821, p = 0.045). However, allele contrast and the dominant model failed to reveal an association between the CCR5-Δ32 polymorphism and bladder cancer, cervical cancer, pancreatic cancer, prostate cancer, and head and neck cancer. CONCLUSIONS: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with susceptibility to cancer in Indians and is associated with breast cancer. SN - 1532-4281 UR - https://www.unboundmedicine.com/medline/citation/25203595/Association_between_chemokine_receptor_5_delta32_polymorphism_and_susceptibility_to_cancer:_a_meta_analysis_ L2 - http://www.tandfonline.com/doi/full/10.3109/10799893.2014.960934 DB - PRIME DP - Unbound Medicine ER -