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Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes.
Mol Genet Genomics. 2015 Feb; 290(1):173-85.MG

Abstract

Ecl1 family genes (ecl1 (+), ecl2 (+), and ecl3 (+)) have been identified as extenders of the chronological lifespan in Schizosaccharomyces pombe. Here, we found that the triple-deletion mutant (∆ecl1/2/3) had a defect in sexual development after entry into the stationary phase, although the mutant essentially showed normal mating and sporulation under nitrogen starvation or carbon limitation. In this study, we showed that limitation of zinc or iron can be a signal for sexual development of S. pombe cells grown in Edinburgh minimal medium until the stationary phase and that Ecl1 family genes are important for this process. Because the ∆ecl1/2/3 mutant diminishes the zinc depletion-dependent gene expression, Ecl1 family proteins may function as zinc sensors in the process of sexual development.

Authors+Show Affiliations

Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-Ku, Nagoya, 464-8601, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25204792

Citation

Ohtsuka, Hokuto, et al. "Sexual Development of Schizosaccharomyces Pombe Is Induced By Zinc or Iron Limitation Through Ecl1 Family Genes." Molecular Genetics and Genomics : MGG, vol. 290, no. 1, 2015, pp. 173-85.
Ohtsuka H, Ishida M, Naito C, et al. Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes. Mol Genet Genomics. 2015;290(1):173-85.
Ohtsuka, H., Ishida, M., Naito, C., Murakami, H., & Aiba, H. (2015). Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes. Molecular Genetics and Genomics : MGG, 290(1), 173-85. https://doi.org/10.1007/s00438-014-0911-8
Ohtsuka H, et al. Sexual Development of Schizosaccharomyces Pombe Is Induced By Zinc or Iron Limitation Through Ecl1 Family Genes. Mol Genet Genomics. 2015;290(1):173-85. PubMed PMID: 25204792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes. AU - Ohtsuka,Hokuto, AU - Ishida,Maiko, AU - Naito,Chikako, AU - Murakami,Hiroshi, AU - Aiba,Hirofumi, Y1 - 2014/09/10/ PY - 2013/12/26/received PY - 2014/08/26/accepted PY - 2014/9/11/entrez PY - 2014/9/11/pubmed PY - 2015/4/7/medline SP - 173 EP - 85 JF - Molecular genetics and genomics : MGG JO - Mol Genet Genomics VL - 290 IS - 1 N2 - Ecl1 family genes (ecl1 (+), ecl2 (+), and ecl3 (+)) have been identified as extenders of the chronological lifespan in Schizosaccharomyces pombe. Here, we found that the triple-deletion mutant (∆ecl1/2/3) had a defect in sexual development after entry into the stationary phase, although the mutant essentially showed normal mating and sporulation under nitrogen starvation or carbon limitation. In this study, we showed that limitation of zinc or iron can be a signal for sexual development of S. pombe cells grown in Edinburgh minimal medium until the stationary phase and that Ecl1 family genes are important for this process. Because the ∆ecl1/2/3 mutant diminishes the zinc depletion-dependent gene expression, Ecl1 family proteins may function as zinc sensors in the process of sexual development. SN - 1617-4623 UR - https://www.unboundmedicine.com/medline/citation/25204792/Sexual_development_of_Schizosaccharomyces_pombe_is_induced_by_zinc_or_iron_limitation_through_Ecl1_family_genes_ L2 - https://doi.org/10.1007/s00438-014-0911-8 DB - PRIME DP - Unbound Medicine ER -