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Do children make you happier? Sustained child-wish and mental health in women 11-17 years after fertility treatment.
Hum Reprod 2014; 29(10):2238-46HR

Abstract

STUDY QUESTION

Are fertility treatment-related factors, parenthood status and sustained child-wish associated with women's long-term mental health?

SUMMARY ANSWER

Sustaining a child-wish is more strongly associated with women's long-term mental health than fertility treatment-related factors and parenthood status.

WHAT IS KNOWN ALREADY

About one-third of the couples starting fertility treatment do not achieve parenthood and have to adjust to an unfulfilled child-wish. In women, remaining childless after treatment is associated with less favourable mental health. It is unclear if this is only related to their childlessness or if adjustment after unsuccessful treatment is affected by other variables. These include diagnostic and treatment-related factors (cause of fertility problems, age at first consultation, type and number of treatments) and the psychological ability to come to terms with the unfulfilled child-wish. Differentiating the relative contribution of these factors to women's long-term mental health will provide useful knowledge to support patients adjusting to negative treatment outcomes.

STUDY DESIGN, SIZE, DURATION

A cross-sectional study with a nationally representative sample of 7148 women who started fertility treatment at any of the 12 IVF hospitals in the Netherlands from 1995 through 2000. Of 16 482 women who were invited to participate, 7148 (43.4%) provided psychological data.

PARTICIPANTS/MATERIALS, SETTING, METHODS

The average age of women was 47 years and the average age at first fertility consultation was 30 years. Fifty-one per cent of women did IUI and 85% did IVF/ICSI. Ninety per cent of women were married/cohabiting, 20.9% remained childless and 5.9% had a child-wish. Women completed a questionnaire assessing diagnostic and treatment factors (retrospective data), parenthood status, sustained child-wish and mental health.

MAIN RESULTS AND THE ROLE OF CHANCE

A multiple regression analysis controlling for background variables showed that, first, male factor (P < 0.05) and/or idiopathic infertility (P < 0.001) were associated with better mental health. Secondly, starting fertility treatment at an older age was associated with better mental health (P < 0.01). Thirdly, the interaction between parenthood status and sustained child-wish was significant (P < 0.01). Having a child-wish was associated with worse mental health for women with (β = -0.058, P < 0.01) and without children (β =-0.136, P < 0.001), but associations were stronger for the latter. Predictive factors accounted for <5% of the variation in mental health status in the study population.

LIMITATIONS, REASONS FOR CAUTION

The sample was large and nationally representative. Response rate was in line with other studies but women without psychological data were less likely to have biological children and 15.9% of non-responders considered the questionnaire to be too confronting or to elicit too emotional memories. This could reflect an underestimation of the proportion of women with a sustained child-wish.

WIDER IMPLICATIONS OF THE FINDINGS

Sustaining a child-wish is a more important risk for long-term adjustment problems than parenthood status. Women adjust better when they start treatment at older ages and know they were not responsible for the cause of the fertility problem. Fertility staff can play an important role in preparing patients for the possibility of treatment failure and the associated grief process. They can also inform patients about the positive effect of refocusing their life goals.

STUDY FUNDING/COMPETING INTERESTS

This study was supported by a grant from the Dutch Cancer Society (2006-3631). No competing interests exist.

TRIAL REGISTRATION NUMBER

N/A.

Authors+Show Affiliations

Cardiff Fertility Studies Research Group, School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, Wales CF10 3AT, UK gameiros@cardiff.ac.uk.Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam CX 1066, The Netherlands.Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam CX 1066, The Netherlands.Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, PO-Box 9101, Nijmegen HB 6500, The Netherlands.Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam CX 1066, The Netherlands.Department of Medical Psychology, Radboud University Nijmegen, Medical Centre, PO Box 9101, Nijmegen HB 6500, The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25205751

Citation

Gameiro, Sofia, et al. "Do Children Make You Happier? Sustained Child-wish and Mental Health in Women 11-17 Years After Fertility Treatment." Human Reproduction (Oxford, England), vol. 29, no. 10, 2014, pp. 2238-46.
Gameiro S, van den Belt-Dusebout AW, Bleiker E, et al. Do children make you happier? Sustained child-wish and mental health in women 11-17 years after fertility treatment. Hum Reprod. 2014;29(10):2238-46.
Gameiro, S., van den Belt-Dusebout, A. W., Bleiker, E., Braat, D., van Leeuwen, F. E., & Verhaak, C. M. (2014). Do children make you happier? Sustained child-wish and mental health in women 11-17 years after fertility treatment. Human Reproduction (Oxford, England), 29(10), pp. 2238-46. doi:10.1093/humrep/deu178.
Gameiro S, et al. Do Children Make You Happier? Sustained Child-wish and Mental Health in Women 11-17 Years After Fertility Treatment. Hum Reprod. 2014 Oct 10;29(10):2238-46. PubMed PMID: 25205751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do children make you happier? Sustained child-wish and mental health in women 11-17 years after fertility treatment. AU - Gameiro,Sofia, AU - van den Belt-Dusebout,Alexandra W, AU - Bleiker,Eveline, AU - Braat,Didi, AU - van Leeuwen,Flora E, AU - Verhaak,Christianne M, Y1 - 2014/09/09/ PY - 2014/9/11/entrez PY - 2014/9/11/pubmed PY - 2015/6/11/medline KW - child-wish KW - fertility treatment KW - mental health KW - parenthood status SP - 2238 EP - 46 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 29 IS - 10 N2 - STUDY QUESTION: Are fertility treatment-related factors, parenthood status and sustained child-wish associated with women's long-term mental health? SUMMARY ANSWER: Sustaining a child-wish is more strongly associated with women's long-term mental health than fertility treatment-related factors and parenthood status. WHAT IS KNOWN ALREADY: About one-third of the couples starting fertility treatment do not achieve parenthood and have to adjust to an unfulfilled child-wish. In women, remaining childless after treatment is associated with less favourable mental health. It is unclear if this is only related to their childlessness or if adjustment after unsuccessful treatment is affected by other variables. These include diagnostic and treatment-related factors (cause of fertility problems, age at first consultation, type and number of treatments) and the psychological ability to come to terms with the unfulfilled child-wish. Differentiating the relative contribution of these factors to women's long-term mental health will provide useful knowledge to support patients adjusting to negative treatment outcomes. STUDY DESIGN, SIZE, DURATION: A cross-sectional study with a nationally representative sample of 7148 women who started fertility treatment at any of the 12 IVF hospitals in the Netherlands from 1995 through 2000. Of 16 482 women who were invited to participate, 7148 (43.4%) provided psychological data. PARTICIPANTS/MATERIALS, SETTING, METHODS: The average age of women was 47 years and the average age at first fertility consultation was 30 years. Fifty-one per cent of women did IUI and 85% did IVF/ICSI. Ninety per cent of women were married/cohabiting, 20.9% remained childless and 5.9% had a child-wish. Women completed a questionnaire assessing diagnostic and treatment factors (retrospective data), parenthood status, sustained child-wish and mental health. MAIN RESULTS AND THE ROLE OF CHANCE: A multiple regression analysis controlling for background variables showed that, first, male factor (P < 0.05) and/or idiopathic infertility (P < 0.001) were associated with better mental health. Secondly, starting fertility treatment at an older age was associated with better mental health (P < 0.01). Thirdly, the interaction between parenthood status and sustained child-wish was significant (P < 0.01). Having a child-wish was associated with worse mental health for women with (β = -0.058, P < 0.01) and without children (β =-0.136, P < 0.001), but associations were stronger for the latter. Predictive factors accounted for <5% of the variation in mental health status in the study population. LIMITATIONS, REASONS FOR CAUTION: The sample was large and nationally representative. Response rate was in line with other studies but women without psychological data were less likely to have biological children and 15.9% of non-responders considered the questionnaire to be too confronting or to elicit too emotional memories. This could reflect an underestimation of the proportion of women with a sustained child-wish. WIDER IMPLICATIONS OF THE FINDINGS: Sustaining a child-wish is a more important risk for long-term adjustment problems than parenthood status. Women adjust better when they start treatment at older ages and know they were not responsible for the cause of the fertility problem. Fertility staff can play an important role in preparing patients for the possibility of treatment failure and the associated grief process. They can also inform patients about the positive effect of refocusing their life goals. STUDY FUNDING/COMPETING INTERESTS: This study was supported by a grant from the Dutch Cancer Society (2006-3631). No competing interests exist. TRIAL REGISTRATION NUMBER: N/A. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/25205751/Do_children_make_you_happier_Sustained_child_wish_and_mental_health_in_women_11_17_years_after_fertility_treatment_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deu178 DB - PRIME DP - Unbound Medicine ER -