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Ursolic acid induces neural regeneration after sciatic nerve injury.
Neural Regen Res 2013; 8(27):2510-9NR

Abstract

In this study, we aimed to explore the role of ursolic acid in the neural regeneration of the injured sciatic nerve. BALB/c mice were used to establish models of sciatic nerve injury through unilateral sciatic nerve complete transection and microscopic anastomosis at 0.5 cm below the ischial tube-rosity. The successfully generated model mice were treated with 10, 5, or 2.5 mg/kg ursolic acid via intraperitoneal injection. Enzyme-linked immunosorbent assay results showed that serum S100 protein expression level gradually increased at 1-4 weeks after sciatic nerve injury, and significantly decreased at 8 weeks. As such, ursolic acid has the capacity to significantly increase S100 protein expression levels. Real-time quantitative PCR showed that S100 mRNA expression in the L4-6 segments on the injury side was increased after ursolic acid treatment. In addition, the muscular mass index in the soleus muscle was also increased in mice treated with ursolic acid. Toluidine blue staining revealed that the quantity and average diameter of myelinated nerve fibers in the injured sciatic nerve were significantly increased after treatment with ursolic acid. 10 and 5 mg/kg of ursolic acid produced stronger effects than 2.5 mg/kg of ursolic acid. Our findings indicate that ursolic acid can dose-dependently increase S100 expression and promote neural regeneration in BALB/c mice following sciatic nerve injury.

Authors+Show Affiliations

Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25206561

Citation

Liu, Biao, et al. "Ursolic Acid Induces Neural Regeneration After Sciatic Nerve Injury." Neural Regeneration Research, vol. 8, no. 27, 2013, pp. 2510-9.
Liu B, Liu Y, Yang G, et al. Ursolic acid induces neural regeneration after sciatic nerve injury. Neural Regen Res. 2013;8(27):2510-9.
Liu, B., Liu, Y., Yang, G., Xu, Z., & Chen, J. (2013). Ursolic acid induces neural regeneration after sciatic nerve injury. Neural Regeneration Research, 8(27), pp. 2510-9. doi:10.3969/j.issn.1673-5374.2013.27.002.
Liu B, et al. Ursolic Acid Induces Neural Regeneration After Sciatic Nerve Injury. Neural Regen Res. 2013 Sep 25;8(27):2510-9. PubMed PMID: 25206561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ursolic acid induces neural regeneration after sciatic nerve injury. AU - Liu,Biao, AU - Liu,Yan, AU - Yang,Guang, AU - Xu,Zemin, AU - Chen,Jiajun, PY - 2013/03/25/received PY - 2013/07/01/accepted PY - 2014/9/11/entrez PY - 2014/9/11/pubmed PY - 2014/9/11/medline KW - S100 KW - grants-supported paper KW - muscular atrophy KW - nerve myelin sheath KW - neural regeneration KW - neuroregeneration KW - peripheral nerve injury KW - sciatic nerve KW - traditional Chinese medicine KW - triterpenoid KW - ursolic acid SP - 2510 EP - 9 JF - Neural regeneration research JO - Neural Regen Res VL - 8 IS - 27 N2 - In this study, we aimed to explore the role of ursolic acid in the neural regeneration of the injured sciatic nerve. BALB/c mice were used to establish models of sciatic nerve injury through unilateral sciatic nerve complete transection and microscopic anastomosis at 0.5 cm below the ischial tube-rosity. The successfully generated model mice were treated with 10, 5, or 2.5 mg/kg ursolic acid via intraperitoneal injection. Enzyme-linked immunosorbent assay results showed that serum S100 protein expression level gradually increased at 1-4 weeks after sciatic nerve injury, and significantly decreased at 8 weeks. As such, ursolic acid has the capacity to significantly increase S100 protein expression levels. Real-time quantitative PCR showed that S100 mRNA expression in the L4-6 segments on the injury side was increased after ursolic acid treatment. In addition, the muscular mass index in the soleus muscle was also increased in mice treated with ursolic acid. Toluidine blue staining revealed that the quantity and average diameter of myelinated nerve fibers in the injured sciatic nerve were significantly increased after treatment with ursolic acid. 10 and 5 mg/kg of ursolic acid produced stronger effects than 2.5 mg/kg of ursolic acid. Our findings indicate that ursolic acid can dose-dependently increase S100 expression and promote neural regeneration in BALB/c mice following sciatic nerve injury. SN - 1673-5374 UR - https://www.unboundmedicine.com/medline/citation/25206561/Ursolic_acid_induces_neural_regeneration_after_sciatic_nerve_injury_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25206561/ DB - PRIME DP - Unbound Medicine ER -