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Critical illness polyneuropathy and myopathy: a systematic review.
Neural Regen Res. 2014 Jan 01; 9(1):101-10.NR

Abstract

Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles, respectively. Clinically, they manifest as limb and respiratory muscle weakness. Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation. Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event. Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy. Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population. The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical, diagnostic, differentiating, and treatment information for this debilitating neurological disease.

Authors+Show Affiliations

Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China ; Department of Neurology, the Second Part, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China ; Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, MA, USA.Department of Radiotherapy, Oncology Center, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.Department of Vascular Surgery, People's Hospital of Jilin Province, Changchun 130000, Jilin Province, China.Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25206749

Citation

Zhou, Chunkui, et al. "Critical Illness Polyneuropathy and Myopathy: a Systematic Review." Neural Regeneration Research, vol. 9, no. 1, 2014, pp. 101-10.
Zhou C, Wu L, Ni F, et al. Critical illness polyneuropathy and myopathy: a systematic review. Neural Regen Res. 2014;9(1):101-10.
Zhou, C., Wu, L., Ni, F., Ji, W., Wu, J., & Zhang, H. (2014). Critical illness polyneuropathy and myopathy: a systematic review. Neural Regeneration Research, 9(1), 101-10. https://doi.org/10.4103/1673-5374.125337
Zhou C, et al. Critical Illness Polyneuropathy and Myopathy: a Systematic Review. Neural Regen Res. 2014 Jan 1;9(1):101-10. PubMed PMID: 25206749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Critical illness polyneuropathy and myopathy: a systematic review. AU - Zhou,Chunkui, AU - Wu,Limin, AU - Ni,Fengming, AU - Ji,Wei, AU - Wu,Jiang, AU - Zhang,Hongliang, PY - 2013/11/25/accepted PY - 2014/9/11/entrez PY - 2014/9/11/pubmed PY - 2014/9/11/medline KW - Guillain-Barré syndrome KW - NSFC grant KW - critical illness myopathy KW - critical illness polyneuropathy KW - intensive care unit KW - multiple organ failure KW - nerve regeneration KW - neural regeneration KW - neurodegenerative diseases KW - sepsis SP - 101 EP - 10 JF - Neural regeneration research JO - Neural Regen Res VL - 9 IS - 1 N2 - Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles, respectively. Clinically, they manifest as limb and respiratory muscle weakness. Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation. Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event. Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy. Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population. The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical, diagnostic, differentiating, and treatment information for this debilitating neurological disease. SN - 1673-5374 UR - https://www.unboundmedicine.com/medline/citation/25206749/full_citation L2 - http://www.nrronline.org/article.asp?issn=1673-5374;year=2014;volume=9;issue=1;spage=101;epage=110;aulast=Zhou DB - PRIME DP - Unbound Medicine ER -
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