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The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012).
Balkan Med J. 2013 Mar; 30(1):4-7.BM

Abstract

At the end of the 19(th) century, it was envisaged by Santiago Ramon y Cajal, but not, proven, that life at the neuronal level requires trophic support. The proof was obtained in the early 1950's by work initiated by Rita Levi-Montalcini (RLM) discovering the nerve growth factor (NGF). Today, NGF and its relatives, collectively designated neurotrophins, are well recognized as mediators of multiple biological phenomena in health and disease, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other neurotrophins are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, from Alzheimer's and other neurodegenerative diseases to atherosclerosis and other cardiometabolic diseases. Recent studies demonstrated the therapeutic potentials of NGF in these diseases, including ocular and cutaneous diseases. Furthermore, NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma, and urinary bladder syndromes. Altogether, NGF's multiple potential in health and disease is briefly described here.

Authors+Show Affiliations

Institute of Cell Biology and Neurobiology, National Research Council (CNR), Rome, Italy.Laboratory of Cell Biology, Medical University, Varna, Bulgaria.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25207059

Citation

Aloe, Luigi, and George N. Chaldakov. "The Multiple Life of Nerve Growth Factor: Tribute to Rita Levi-montalcini (1909-2012)." Balkan Medical Journal, vol. 30, no. 1, 2013, pp. 4-7.
Aloe L, Chaldakov GN. The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012). Balkan Med J. 2013;30(1):4-7.
Aloe, L., & Chaldakov, G. N. (2013). The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012). Balkan Medical Journal, 30(1), 4-7. https://doi.org/10.5152/balkanmedj.2013.003
Aloe L, Chaldakov GN. The Multiple Life of Nerve Growth Factor: Tribute to Rita Levi-montalcini (1909-2012). Balkan Med J. 2013;30(1):4-7. PubMed PMID: 25207059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012). AU - Aloe,Luigi, AU - Chaldakov,George N, Y1 - 2013/02/28/ PY - 2013/02/26/received PY - 2013/03/06/accepted PY - 2014/9/11/entrez PY - 2013/3/1/pubmed PY - 2013/3/1/medline KW - Nerve growth factor KW - TrkA KW - disease KW - neuronal cells KW - non-neuronal cells KW - p75NTR KW - therapy SP - 4 EP - 7 JF - Balkan medical journal JO - Balkan Med J VL - 30 IS - 1 N2 - At the end of the 19(th) century, it was envisaged by Santiago Ramon y Cajal, but not, proven, that life at the neuronal level requires trophic support. The proof was obtained in the early 1950's by work initiated by Rita Levi-Montalcini (RLM) discovering the nerve growth factor (NGF). Today, NGF and its relatives, collectively designated neurotrophins, are well recognized as mediators of multiple biological phenomena in health and disease, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other neurotrophins are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, from Alzheimer's and other neurodegenerative diseases to atherosclerosis and other cardiometabolic diseases. Recent studies demonstrated the therapeutic potentials of NGF in these diseases, including ocular and cutaneous diseases. Furthermore, NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma, and urinary bladder syndromes. Altogether, NGF's multiple potential in health and disease is briefly described here. SN - 2146-3123 UR - https://www.unboundmedicine.com/medline/citation/25207059/The_multiple_life_of_nerve_growth_factor:_tribute_to_rita_levi_montalcini__1909_2012__ L2 - https://doi.org/10.5152/balkanmedj.2013.003 DB - PRIME DP - Unbound Medicine ER -
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