Tags

Type your tag names separated by a space and hit enter

The good and bad effects of statins on insulin sensitivity and secretion.
Endocr Res. 2014; 39(4):137-43.ER

Abstract

AIMS

Statins are the main lipid-lowering treatment in both primary and secondary prevention populations. Whether statins deteriorates glycemic control, predisposing to the onset of diabetes mellitus has been a matter of recent concern. Statins may accelerate progression to diabetes via molecular mechanisms that impact insulin sensitivity and secretion. In this review, we debate the relative effect of statins in driving insulin resistance and the impairment of insulin secretion.

METHODS

Narrative overview of the literature synthesizing the findings of literature was retrieved from searches of computerized databases, hand searches, and authoritative texts employing the key words "Statins", "Randomized Clinical Trial", "Insulin sensitivity", "Insulin resistance", "Insulin Secretion", "Diabetes Mellitus" alone and/or in combination.

RESULTS

The weight of clinical evidence suggests a worsening effect of statins on insulin resistance and secretion, anyway basic science studies did not find a clear molecular explanation, providing conflicting evidence regarding both the beneficial and the adverse effects of statin therapy on insulin sensitivity.

CONCLUSIONS

Although most of the clinical studies suggest a worsening of insulin resistance and secretion, the cardiovascular benefits of statin therapy outweigh the risk of developing insulin resistance, thus the data suggest the need to treat dyslipidemia and to make patients aware of the possible risk of developing type 2 diabetes or, if they already are diabetic, of worsening their metabolic control.

Authors+Show Affiliations

Department of Clinical Medicine and Surgery, University "Federico II" , Naples , Italy .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25208056

Citation

Muscogiuri, Giovanna, et al. "The Good and Bad Effects of Statins On Insulin Sensitivity and Secretion." Endocrine Research, vol. 39, no. 4, 2014, pp. 137-43.
Muscogiuri G, Sarno G, Gastaldelli A, et al. The good and bad effects of statins on insulin sensitivity and secretion. Endocr Res. 2014;39(4):137-43.
Muscogiuri, G., Sarno, G., Gastaldelli, A., Savastano, S., Ascione, A., Colao, A., & Orio, F. (2014). The good and bad effects of statins on insulin sensitivity and secretion. Endocrine Research, 39(4), 137-43. https://doi.org/10.3109/07435800.2014.952018
Muscogiuri G, et al. The Good and Bad Effects of Statins On Insulin Sensitivity and Secretion. Endocr Res. 2014;39(4):137-43. PubMed PMID: 25208056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The good and bad effects of statins on insulin sensitivity and secretion. AU - Muscogiuri,Giovanna, AU - Sarno,Gerardo, AU - Gastaldelli,Amalia, AU - Savastano,Silvia, AU - Ascione,Antonio, AU - Colao,Annamaria, AU - Orio,Francesco, Y1 - 2014/09/10/ PY - 2014/9/11/entrez PY - 2014/9/11/pubmed PY - 2015/6/13/medline KW - Cardiovascular disease KW - dyslipidemia KW - insulin resistance KW - insulin secretion KW - statins KW - type 2 diabetes SP - 137 EP - 43 JF - Endocrine research JO - Endocr. Res. VL - 39 IS - 4 N2 - AIMS: Statins are the main lipid-lowering treatment in both primary and secondary prevention populations. Whether statins deteriorates glycemic control, predisposing to the onset of diabetes mellitus has been a matter of recent concern. Statins may accelerate progression to diabetes via molecular mechanisms that impact insulin sensitivity and secretion. In this review, we debate the relative effect of statins in driving insulin resistance and the impairment of insulin secretion. METHODS: Narrative overview of the literature synthesizing the findings of literature was retrieved from searches of computerized databases, hand searches, and authoritative texts employing the key words "Statins", "Randomized Clinical Trial", "Insulin sensitivity", "Insulin resistance", "Insulin Secretion", "Diabetes Mellitus" alone and/or in combination. RESULTS: The weight of clinical evidence suggests a worsening effect of statins on insulin resistance and secretion, anyway basic science studies did not find a clear molecular explanation, providing conflicting evidence regarding both the beneficial and the adverse effects of statin therapy on insulin sensitivity. CONCLUSIONS: Although most of the clinical studies suggest a worsening of insulin resistance and secretion, the cardiovascular benefits of statin therapy outweigh the risk of developing insulin resistance, thus the data suggest the need to treat dyslipidemia and to make patients aware of the possible risk of developing type 2 diabetes or, if they already are diabetic, of worsening their metabolic control. SN - 1532-4206 UR - https://www.unboundmedicine.com/medline/citation/25208056/The_good_and_bad_effects_of_statins_on_insulin_sensitivity_and_secretion_ L2 - http://www.tandfonline.com/doi/full/10.3109/07435800.2014.952018 DB - PRIME DP - Unbound Medicine ER -