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Body mass index and the risk of gout: a systematic review and dose-response meta-analysis of prospective studies.

Abstract

PURPOSE

Greater body fatness has been associated with increased risk of gout in several studies; however, the strength of the association has differed between studies, and it is not clear whether the association differs by gender. We conducted a systematic review and meta-analysis of prospective studies to clarify the association between adiposity and risk of gout.

METHODS

PubMed and Embase were searched up to August 30, 2013. Summary relative risks (RRs) were calculated using a random effects model.

RESULTS

Ten prospective studies of body mass index (BMI) and gout risk with 27,944 cases and 215,739 participants were included (median follow-up 10.5 years). The summary RR for a 5 unit increment was 1.55 [95% confidence interval (95% CI) 1.44-1.66, I(2) = 67%] for all studies combined. The heterogeneity was explained by one study, which appeared to be an outlier. The summary RR per 5 BMI units was 1.62 (95% CI 1.33-1.98, I(2) = 79%) for men and 1.49 (95% CI 1.32-1.68, I(2) = 30%) for women, p(heterogeneity) = 0.72. The relative risks were 1.78, 2.67, 3.62, and 4.64 for persons with BMI 25, 30, 35, and 40 compared with persons with a BMI of 20. BMI in young adulthood, waist-to-hip ratio, and weight gain from age 21-25 to midlife were also associated with increased risk, but few studies were included in these analyses.

CONCLUSIONS

Greater body mass index increases risk of gout. Further studies are needed on adiposity throughout the life course, waist-to-hip ratio, and weight changes in relation to gout as there were few studies that had published on these exposures.

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  • Authors+Show Affiliations

    ,

    Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway, d.aune@imperial.ac.uk.

    ,

    Source

    European journal of nutrition 53:8 2014 Dec pg 1591-601

    MeSH

    Adiposity
    Body Mass Index
    Databases, Factual
    Female
    Gout
    Humans
    Male
    Obesity
    Prevalence
    Risk Factors
    Sensitivity and Specificity
    Waist-Hip Ratio
    Weight Gain

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    25209031

    Citation

    Aune, Dagfinn, et al. "Body Mass Index and the Risk of Gout: a Systematic Review and Dose-response Meta-analysis of Prospective Studies." European Journal of Nutrition, vol. 53, no. 8, 2014, pp. 1591-601.
    Aune D, Norat T, Vatten LJ. Body mass index and the risk of gout: a systematic review and dose-response meta-analysis of prospective studies. Eur J Nutr. 2014;53(8):1591-601.
    Aune, D., Norat, T., & Vatten, L. J. (2014). Body mass index and the risk of gout: a systematic review and dose-response meta-analysis of prospective studies. European Journal of Nutrition, 53(8), pp. 1591-601. doi:10.1007/s00394-014-0766-0.
    Aune D, Norat T, Vatten LJ. Body Mass Index and the Risk of Gout: a Systematic Review and Dose-response Meta-analysis of Prospective Studies. Eur J Nutr. 2014;53(8):1591-601. PubMed PMID: 25209031.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body mass index and the risk of gout: a systematic review and dose-response meta-analysis of prospective studies. AU - Aune,Dagfinn, AU - Norat,Teresa, AU - Vatten,Lars J, Y1 - 2014/09/11/ PY - 2014/02/14/received PY - 2014/09/02/accepted PY - 2014/9/12/entrez PY - 2014/9/12/pubmed PY - 2015/8/14/medline SP - 1591 EP - 601 JF - European journal of nutrition JO - Eur J Nutr VL - 53 IS - 8 N2 - PURPOSE: Greater body fatness has been associated with increased risk of gout in several studies; however, the strength of the association has differed between studies, and it is not clear whether the association differs by gender. We conducted a systematic review and meta-analysis of prospective studies to clarify the association between adiposity and risk of gout. METHODS: PubMed and Embase were searched up to August 30, 2013. Summary relative risks (RRs) were calculated using a random effects model. RESULTS: Ten prospective studies of body mass index (BMI) and gout risk with 27,944 cases and 215,739 participants were included (median follow-up 10.5 years). The summary RR for a 5 unit increment was 1.55 [95% confidence interval (95% CI) 1.44-1.66, I(2) = 67%] for all studies combined. The heterogeneity was explained by one study, which appeared to be an outlier. The summary RR per 5 BMI units was 1.62 (95% CI 1.33-1.98, I(2) = 79%) for men and 1.49 (95% CI 1.32-1.68, I(2) = 30%) for women, p(heterogeneity) = 0.72. The relative risks were 1.78, 2.67, 3.62, and 4.64 for persons with BMI 25, 30, 35, and 40 compared with persons with a BMI of 20. BMI in young adulthood, waist-to-hip ratio, and weight gain from age 21-25 to midlife were also associated with increased risk, but few studies were included in these analyses. CONCLUSIONS: Greater body mass index increases risk of gout. Further studies are needed on adiposity throughout the life course, waist-to-hip ratio, and weight changes in relation to gout as there were few studies that had published on these exposures. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/25209031/full_citation L2 - https://dx.doi.org/10.1007/s00394-014-0766-0 DB - PRIME DP - Unbound Medicine ER -