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How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume?
J Pediatr Endocrinol Metab. 2015 Mar; 28(3-4):275-8.JP

Abstract

AIM

To investigate whether autoimmune thyroiditis (AIT) in children with type 1 diabetes mellitus (DM1) has any influence on glycemic control, lipid profile or thyroid volume.

METHODS

A total of 330 patients with DM1 and AIT (DM1+AIT group) were compared with 309 children with DM1 without AIT (control group). Patients were treated in four Polish academic pediatric diabetes centers from 2008 to 2012: Warsaw, Lodz, Katowice and Gdansk. All patients underwent measurements of thyroid-stimulating hormone (TSH), free thyroxine, anti-thyroid peroxidase (anti-TPO) antibody, anti-thyroglobulin (anti-TG) antibody and HbA1c levels, and thyroid ultrasound examination.

RESULTS

Among AIT+DM1 patients, 62% (n=205) were female, whereas in the control group 60.8% (n=188) were male (p<0.0001). Children with AIT+DM1 had lower a BMI-SDS (mean difference of -0.5, 95% CI -0.68 to -0.33; p<0.0001), had a higher SDS thyroid volume (0.27, 95% CI 0.03-0.51; p=0.014) and needed less insulin (-0.15, 95% CI -0.20 to -0.11 U/kg body weight per day; p<0.0001) in comparison with the control group. AIT patients had higher HbA1c levels (0.66, 95% CI 0.36%-0.96%, p<0.0001), lower HDL-cholesterol levels (-3.68, 95% CI -1.41 to -5.94 mg/dL, p=0.002) and higher triglyceride levels (7.16, 95% CI 1.22-13.10 mg/dL, p=0.02). Patients with positive anti-TPO and anti-TG antibodies were older (by 1.95 years, 95% CI 0.98-2.92 years, p=0.006) and had longer DM1 duration (by 1.64 years, 95% CI 0.76-2.52 years, p=0.006). Presence of anti-TPO antibodies was associated with higher TSH levels (odds ratio 2.34, 95% CI 1.36-4.04; p=0.007).

CONCLUSION

AIT accompanying DM1 is associated with worse glycemic control and lipid profile as well as a lower daily insulin requirement. The female gender is more likely to develop AIT and hypothyroidism.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

25210750

Citation

Korzeniowska, Katarzyna, et al. "How Does Autoimmune Thyroiditis in Children With Type 1 Diabetes Mellitus Influence Glycemic Control, Lipid Profile and Thyroid Volume?" Journal of Pediatric Endocrinology & Metabolism : JPEM, vol. 28, no. 3-4, 2015, pp. 275-8.
Korzeniowska K, Ramotowska A, Szypowska A, et al. How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume? J Pediatr Endocrinol Metab. 2015;28(3-4):275-8.
Korzeniowska, K., Ramotowska, A., Szypowska, A., Szadkowska, A., Fendler, W., Kalina-Faska, B., Młynarski, W., Jarosz-Chobot, P., & Myśliwiec, M. (2015). How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume? Journal of Pediatric Endocrinology & Metabolism : JPEM, 28(3-4), 275-8. https://doi.org/10.1515/jpem-2013-0455
Korzeniowska K, et al. How Does Autoimmune Thyroiditis in Children With Type 1 Diabetes Mellitus Influence Glycemic Control, Lipid Profile and Thyroid Volume. J Pediatr Endocrinol Metab. 2015;28(3-4):275-8. PubMed PMID: 25210750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume? AU - Korzeniowska,Katarzyna, AU - Ramotowska,Anna, AU - Szypowska,Agnieszka, AU - Szadkowska,Agnieszka, AU - Fendler,Wojciech, AU - Kalina-Faska,Barbara, AU - Młynarski,Wojciech, AU - Jarosz-Chobot,Przemyslawa, AU - Myśliwiec,Malgorzata, PY - 2013/12/03/received PY - 2014/08/14/accepted PY - 2014/9/12/entrez PY - 2014/9/12/pubmed PY - 2016/3/25/medline SP - 275 EP - 8 JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J. Pediatr. Endocrinol. Metab. VL - 28 IS - 3-4 N2 - AIM: To investigate whether autoimmune thyroiditis (AIT) in children with type 1 diabetes mellitus (DM1) has any influence on glycemic control, lipid profile or thyroid volume. METHODS: A total of 330 patients with DM1 and AIT (DM1+AIT group) were compared with 309 children with DM1 without AIT (control group). Patients were treated in four Polish academic pediatric diabetes centers from 2008 to 2012: Warsaw, Lodz, Katowice and Gdansk. All patients underwent measurements of thyroid-stimulating hormone (TSH), free thyroxine, anti-thyroid peroxidase (anti-TPO) antibody, anti-thyroglobulin (anti-TG) antibody and HbA1c levels, and thyroid ultrasound examination. RESULTS: Among AIT+DM1 patients, 62% (n=205) were female, whereas in the control group 60.8% (n=188) were male (p<0.0001). Children with AIT+DM1 had lower a BMI-SDS (mean difference of -0.5, 95% CI -0.68 to -0.33; p<0.0001), had a higher SDS thyroid volume (0.27, 95% CI 0.03-0.51; p=0.014) and needed less insulin (-0.15, 95% CI -0.20 to -0.11 U/kg body weight per day; p<0.0001) in comparison with the control group. AIT patients had higher HbA1c levels (0.66, 95% CI 0.36%-0.96%, p<0.0001), lower HDL-cholesterol levels (-3.68, 95% CI -1.41 to -5.94 mg/dL, p=0.002) and higher triglyceride levels (7.16, 95% CI 1.22-13.10 mg/dL, p=0.02). Patients with positive anti-TPO and anti-TG antibodies were older (by 1.95 years, 95% CI 0.98-2.92 years, p=0.006) and had longer DM1 duration (by 1.64 years, 95% CI 0.76-2.52 years, p=0.006). Presence of anti-TPO antibodies was associated with higher TSH levels (odds ratio 2.34, 95% CI 1.36-4.04; p=0.007). CONCLUSION: AIT accompanying DM1 is associated with worse glycemic control and lipid profile as well as a lower daily insulin requirement. The female gender is more likely to develop AIT and hypothyroidism. SN - 2191-0251 UR - https://www.unboundmedicine.com/medline/citation/25210750/How_does_autoimmune_thyroiditis_in_children_with_type_1_diabetes_mellitus_influence_glycemic_control_lipid_profile_and_thyroid_volume L2 - https://www.degruyter.com/doi/10.1515/jpem-2013-0455 DB - PRIME DP - Unbound Medicine ER -