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Effects of exogenous glucagon-like peptide-1 on the blood pressure, heart rate, mesenteric blood flow, and glycemic responses to intraduodenal glucose in healthy older subjects.
J Clin Endocrinol Metab. 2014 Dec; 99(12):E2628-34.JC

Abstract

CONTEXT

Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR).

OBJECTIVE

To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects.

DESIGN

A double-blind randomized trial was conducted.

SETTING

Community-dwelling residents attended a clinical research laboratory.

PATIENTS

Ten healthy "older" subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied.

INTERVENTIONS

Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = -30-60 min). Between t = 0-60 min, ID glucose was infused at 3 kcal/min.

MAIN OUTCOME MEASURES

BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured.

RESULTS

During the fasting period (t = -30-0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0-60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05).

CONCLUSIONS

In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.

Authors+Show Affiliations

Discipline of Medicine (L.G.T., M.H., C.F.-B., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia; National Health and Medical Research Council Centre of Research Excellence in Translating Nutritional Science to Good Health (L.G.T., M.H., C.F.-B., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia; and Section for Gastroenterology (T.H.), Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25210879

Citation

Trahair, Laurence G., et al. "Effects of Exogenous Glucagon-like Peptide-1 On the Blood Pressure, Heart Rate, Mesenteric Blood Flow, and Glycemic Responses to Intraduodenal Glucose in Healthy Older Subjects." The Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 12, 2014, pp. E2628-34.
Trahair LG, Horowitz M, Hausken T, et al. Effects of exogenous glucagon-like peptide-1 on the blood pressure, heart rate, mesenteric blood flow, and glycemic responses to intraduodenal glucose in healthy older subjects. J Clin Endocrinol Metab. 2014;99(12):E2628-34.
Trahair, L. G., Horowitz, M., Hausken, T., Feinle-Bisset, C., Rayner, C. K., & Jones, K. L. (2014). Effects of exogenous glucagon-like peptide-1 on the blood pressure, heart rate, mesenteric blood flow, and glycemic responses to intraduodenal glucose in healthy older subjects. The Journal of Clinical Endocrinology and Metabolism, 99(12), E2628-34. https://doi.org/10.1210/jc.2014-2475
Trahair LG, et al. Effects of Exogenous Glucagon-like Peptide-1 On the Blood Pressure, Heart Rate, Mesenteric Blood Flow, and Glycemic Responses to Intraduodenal Glucose in Healthy Older Subjects. J Clin Endocrinol Metab. 2014;99(12):E2628-34. PubMed PMID: 25210879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of exogenous glucagon-like peptide-1 on the blood pressure, heart rate, mesenteric blood flow, and glycemic responses to intraduodenal glucose in healthy older subjects. AU - Trahair,Laurence G, AU - Horowitz,Michael, AU - Hausken,Trygve, AU - Feinle-Bisset,Christine, AU - Rayner,Christopher K, AU - Jones,Karen L, PY - 2014/9/12/entrez PY - 2014/9/12/pubmed PY - 2015/10/8/medline SP - E2628 EP - 34 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 99 IS - 12 N2 - CONTEXT: Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR). OBJECTIVE: To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects. DESIGN: A double-blind randomized trial was conducted. SETTING: Community-dwelling residents attended a clinical research laboratory. PATIENTS: Ten healthy "older" subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied. INTERVENTIONS: Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = -30-60 min). Between t = 0-60 min, ID glucose was infused at 3 kcal/min. MAIN OUTCOME MEASURES: BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured. RESULTS: During the fasting period (t = -30-0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0-60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05). CONCLUSIONS: In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/25210879/Effects_of_exogenous_glucagon_like_peptide_1_on_the_blood_pressure_heart_rate_mesenteric_blood_flow_and_glycemic_responses_to_intraduodenal_glucose_in_healthy_older_subjects_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2014-2475 DB - PRIME DP - Unbound Medicine ER -