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Nonsense-mediated mRNA decay modulates immune receptor levels to regulate plant antibacterial defense.
Cell Host Microbe. 2014 Sep 10; 16(3):376-90.CH

Abstract

Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to constitutive immune response activation and enhanced antibacterial resistance, but the underlying mechanisms are unknown. Here we show that NMD contributes to innate immunity in Arabidopsis by controlling the turnover of numerous TIR domain-containing, nucleotide-binding, leucine-rich repeat (TNL) immune receptor-encoding mRNAs. Autoimmunity resulting from NMD impairment depends on TNL signaling pathway components and can be triggered through deregulation of a single TNL gene, RPS6. Bacterial infection of plants causes host-programmed inhibition of NMD, leading to stabilization of NMD-regulated TNL transcripts. Conversely, constitutive NMD activity prevents TNL stabilization and impairs plant defense, demonstrating that host-regulated NMD contributes to disease resistance. Thus, NMD shapes plant innate immunity by controlling the threshold for activation of TNL resistance pathways.

Authors+Show Affiliations

Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr.-Bohr-Gasse 3, 1030 Vienna, Austria. Electronic address: jiradet.gloggnitzer@gmi.oeaw.ac.at.Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr.-Bohr-Gasse 3, 1030 Vienna, Austria.Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Cologne, Germany.Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr.-Bohr-Gasse 3, 1030 Vienna, Austria.Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr.-Bohr-Gasse 3, 1030 Vienna, Austria.Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr.-Bohr-Gasse 3, 1030 Vienna, Austria.Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Cologne, Germany.Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr.-Bohr-Gasse 3, 1030 Vienna, Austria.Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr.-Bohr-Gasse 3, 1030 Vienna, Austria.Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Cologne, Germany; Institut Jean-Pierre Bourgin, UMR1318, INRA-AgroParisTech, 78000 Versailles, France.Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Cologne, Germany.Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr.-Bohr-Gasse 3, 1030 Vienna, Austria; CEITEC, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic. Electronic address: karel.riha@ceitec.muni.cz.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25211079

Citation

Gloggnitzer, Jiradet, et al. "Nonsense-mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense." Cell Host & Microbe, vol. 16, no. 3, 2014, pp. 376-90.
Gloggnitzer J, Akimcheva S, Srinivasan A, et al. Nonsense-mediated mRNA decay modulates immune receptor levels to regulate plant antibacterial defense. Cell Host Microbe. 2014;16(3):376-90.
Gloggnitzer, J., Akimcheva, S., Srinivasan, A., Kusenda, B., Riehs, N., Stampfl, H., Bautor, J., Dekrout, B., Jonak, C., Jiménez-Gómez, J. M., Parker, J. E., & Riha, K. (2014). Nonsense-mediated mRNA decay modulates immune receptor levels to regulate plant antibacterial defense. Cell Host & Microbe, 16(3), 376-90. https://doi.org/10.1016/j.chom.2014.08.010
Gloggnitzer J, et al. Nonsense-mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense. Cell Host Microbe. 2014 Sep 10;16(3):376-90. PubMed PMID: 25211079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonsense-mediated mRNA decay modulates immune receptor levels to regulate plant antibacterial defense. AU - Gloggnitzer,Jiradet, AU - Akimcheva,Svetlana, AU - Srinivasan,Arunkumar, AU - Kusenda,Branislav, AU - Riehs,Nina, AU - Stampfl,Hansjörg, AU - Bautor,Jaqueline, AU - Dekrout,Bettina, AU - Jonak,Claudia, AU - Jiménez-Gómez,José M, AU - Parker,Jane E, AU - Riha,Karel, PY - 2014/03/25/received PY - 2014/07/29/revised PY - 2014/08/24/accepted PY - 2014/9/12/entrez PY - 2014/9/12/pubmed PY - 2015/6/17/medline SP - 376 EP - 90 JF - Cell host & microbe JO - Cell Host Microbe VL - 16 IS - 3 N2 - Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to constitutive immune response activation and enhanced antibacterial resistance, but the underlying mechanisms are unknown. Here we show that NMD contributes to innate immunity in Arabidopsis by controlling the turnover of numerous TIR domain-containing, nucleotide-binding, leucine-rich repeat (TNL) immune receptor-encoding mRNAs. Autoimmunity resulting from NMD impairment depends on TNL signaling pathway components and can be triggered through deregulation of a single TNL gene, RPS6. Bacterial infection of plants causes host-programmed inhibition of NMD, leading to stabilization of NMD-regulated TNL transcripts. Conversely, constitutive NMD activity prevents TNL stabilization and impairs plant defense, demonstrating that host-regulated NMD contributes to disease resistance. Thus, NMD shapes plant innate immunity by controlling the threshold for activation of TNL resistance pathways. SN - 1934-6069 UR - https://www.unboundmedicine.com/medline/citation/25211079/Nonsense_mediated_mRNA_decay_modulates_immune_receptor_levels_to_regulate_plant_antibacterial_defense_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1931-3128(14)00302-3 DB - PRIME DP - Unbound Medicine ER -