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Comparison of brain perfusion SPECT parameters accuracy for seizure localization in extratemporal lobe epilepsy with discordant pre-surgical data.
Ann Nucl Med 2015; 29(1):21-8AN

Abstract

OBJECTIVE

Extratemporal lobe epilepsy is difficult to localize. We aimed to define the best parameter(s) of SPECT for confirmation of seizure origin among the region of maximum cerebral perfusion in ictal phase (MP), maximum change of cerebral perfusion from interictal to ictal phase (MC), and maximum extent of hyperperfusion in ictal phase (ME) of (99m)Tc ECD brain perfusion SPECT as well as combined SPECT parameters, and combined SPECT and MRI for seizure localization in extratemporal lobe epilepsy.

MATERIALS AND METHODS

Twenty intractable extratemporal lobe epilepsy patients who had (99m)Tc-ECD brain SPECT were reviewed. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of single SPECT parameter, combined SPECT parameters, and combined SPECT and MRI parameters for localization of seizure origin were calculated using pathology and surgical outcomes (Engel class I and II) as gold standards.

RESULTS

Combined SPECT parameters provided more specificity, PPV and accuracy than single SPECT parameters. The best combined SPECT parameters was MP+MC with 80.6 % accuracy, 92.4 % specificity and 43.8 % PPV. Combination of SPECT parameter with MRI (ME+MRI) was the most sensitive (41.7 %), specific (97.5 %), accurate (88.2 %) parameter and had highest PPV (76.9 %) and NPV (89.3 %) for seizure localization. It improved specificity and PPV when compared to MRI alone.

CONCLUSION

Combined SPECT parameters improved the specificity and accuracy in seizure localization. The most specific and accurate SPECT combination is MP+MC. The combined SPECT parameter with MRI further improved sensitivity, specificity, accuracy, PPV and NPV. The authors recommend using SPECT combination, MP+MC, when MRI is negative and ME+MRI when there is MRI lesion.

Authors+Show Affiliations

Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand, supatporn@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25212388

Citation

Tepmongkol, Supatporn, et al. "Comparison of Brain Perfusion SPECT Parameters Accuracy for Seizure Localization in Extratemporal Lobe Epilepsy With Discordant Pre-surgical Data." Annals of Nuclear Medicine, vol. 29, no. 1, 2015, pp. 21-8.
Tepmongkol S, Tangtrairattanakul K, Lerdlum S, et al. Comparison of brain perfusion SPECT parameters accuracy for seizure localization in extratemporal lobe epilepsy with discordant pre-surgical data. Ann Nucl Med. 2015;29(1):21-8.
Tepmongkol, S., Tangtrairattanakul, K., Lerdlum, S., & Desudchit, T. (2015). Comparison of brain perfusion SPECT parameters accuracy for seizure localization in extratemporal lobe epilepsy with discordant pre-surgical data. Annals of Nuclear Medicine, 29(1), pp. 21-8. doi:10.1007/s12149-014-0905-y.
Tepmongkol S, et al. Comparison of Brain Perfusion SPECT Parameters Accuracy for Seizure Localization in Extratemporal Lobe Epilepsy With Discordant Pre-surgical Data. Ann Nucl Med. 2015;29(1):21-8. PubMed PMID: 25212388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of brain perfusion SPECT parameters accuracy for seizure localization in extratemporal lobe epilepsy with discordant pre-surgical data. AU - Tepmongkol,Supatporn, AU - Tangtrairattanakul,Kanokporn, AU - Lerdlum,Sukalaya, AU - Desudchit,Tayard, Y1 - 2014/09/12/ PY - 2014/06/03/received PY - 2014/09/04/accepted PY - 2014/9/13/entrez PY - 2014/9/13/pubmed PY - 2015/9/22/medline SP - 21 EP - 8 JF - Annals of nuclear medicine JO - Ann Nucl Med VL - 29 IS - 1 N2 - OBJECTIVE: Extratemporal lobe epilepsy is difficult to localize. We aimed to define the best parameter(s) of SPECT for confirmation of seizure origin among the region of maximum cerebral perfusion in ictal phase (MP), maximum change of cerebral perfusion from interictal to ictal phase (MC), and maximum extent of hyperperfusion in ictal phase (ME) of (99m)Tc ECD brain perfusion SPECT as well as combined SPECT parameters, and combined SPECT and MRI for seizure localization in extratemporal lobe epilepsy. MATERIALS AND METHODS: Twenty intractable extratemporal lobe epilepsy patients who had (99m)Tc-ECD brain SPECT were reviewed. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of single SPECT parameter, combined SPECT parameters, and combined SPECT and MRI parameters for localization of seizure origin were calculated using pathology and surgical outcomes (Engel class I and II) as gold standards. RESULTS: Combined SPECT parameters provided more specificity, PPV and accuracy than single SPECT parameters. The best combined SPECT parameters was MP+MC with 80.6 % accuracy, 92.4 % specificity and 43.8 % PPV. Combination of SPECT parameter with MRI (ME+MRI) was the most sensitive (41.7 %), specific (97.5 %), accurate (88.2 %) parameter and had highest PPV (76.9 %) and NPV (89.3 %) for seizure localization. It improved specificity and PPV when compared to MRI alone. CONCLUSION: Combined SPECT parameters improved the specificity and accuracy in seizure localization. The most specific and accurate SPECT combination is MP+MC. The combined SPECT parameter with MRI further improved sensitivity, specificity, accuracy, PPV and NPV. The authors recommend using SPECT combination, MP+MC, when MRI is negative and ME+MRI when there is MRI lesion. SN - 1864-6433 UR - https://www.unboundmedicine.com/medline/citation/25212388/Comparison_of_brain_perfusion_SPECT_parameters_accuracy_for_seizure_localization_in_extratemporal_lobe_epilepsy_with_discordant_pre_surgical_data_ L2 - https://dx.doi.org/10.1007/s12149-014-0905-y DB - PRIME DP - Unbound Medicine ER -