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Comparative metabolic effects of three types of combined oral contraceptive pills in Chinese women.
Contraception. 1989 Jan; 39(1):21-35.C

Abstract

The results of a prospective longitudinal controlled study comparing some metabolic effects of a low-dose levonorgestrel-ethinyl oestradiol combined oral contraceptive (Microgynon 30), a desogestrel-ethinyl oestradiol-containing pill (Marvelon) and a levonorgestrel-ethinyl oestradiol triphasic preparation (Triquilar) after one year of treatment in ethnic Chinese women are presented. Serum cholesterol levels are similar for the three pills at 6 and 12 months of treatment. Marvelon and Triquilar users showed rises in triglyceride levels while Microgynon 30 users had no change after one year of treatment. Lipoprotein fractions showed favourable changes in Triquilar and Marvelon users with significant rise in HDL fractions at 6 and 12 months; Microgynon 30 users had equivocal changes in HDL fractions. Carbohydrate metabolism as reflected by glucose tolerance showed deterioration with all 3 pills, being least with Microgynon 30 and greatest with Marvelon at 12 months.

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Authors+Show Affiliations

Prasad RN
Department of Obstetrics and Gynecology, National University of Singapore, National University Hospital.
Liew D
No affiliation info available
Ratnam SS
No affiliation info available

MeSH

AdolescentAdultCarbohydrate MetabolismChinaCholesterolDesogestrelEthinyl EstradiolEthinyl Estradiol-Norgestrel CombinationFemaleHumansLipid MetabolismLipoproteinsLongitudinal StudiesNorgestrelNorpregnenesProspective StudiesSingaporeTriglycerides

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2521321

Citation

Prasad, R N., et al. "Comparative Metabolic Effects of Three Types of Combined Oral Contraceptive Pills in Chinese Women." Contraception, vol. 39, no. 1, 1989, pp. 21-35.
Prasad RN, Liew D, Ratnam SS. Comparative metabolic effects of three types of combined oral contraceptive pills in Chinese women. Contraception. 1989;39(1):21-35.
Prasad, R. N., Liew, D., & Ratnam, S. S. (1989). Comparative metabolic effects of three types of combined oral contraceptive pills in Chinese women. Contraception, 39(1), 21-35.
Prasad RN, Liew D, Ratnam SS. Comparative Metabolic Effects of Three Types of Combined Oral Contraceptive Pills in Chinese Women. Contraception. 1989;39(1):21-35. PubMed PMID: 2521321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative metabolic effects of three types of combined oral contraceptive pills in Chinese women. AU - Prasad,R N, AU - Liew,D, AU - Ratnam,S S, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez KW - Asia KW - Biology KW - Carbohydrate Metabolic Effects KW - China KW - Cholesterol KW - Comparative Studies KW - Contraception KW - Contraceptive Agents, Estrogen--side effects KW - Contraceptive Agents, Female--side effects KW - Contraceptive Agents, Progestin--side effects KW - Contraceptive Agents--side effects KW - Contraceptive Methods--side effects KW - Developing Countries KW - Eastern Asia KW - Ethinyl Estradiol--side effects KW - Family Planning KW - Glucose Metabolism Effects KW - Hematological Effects KW - Hemic System KW - Levonorgestrel--side effects KW - Lipid Metabolic Effects KW - Lipids KW - Metabolic Effects KW - Oral Contraceptives, Combined--side effects KW - Oral Contraceptives, Phasic--side effects KW - Oral Contraceptives--side effects KW - Physiology KW - Research Methodology KW - Serum Protein Effects KW - Studies SP - 21 EP - 35 JF - Contraception JO - Contraception VL - 39 IS - 1 N2 - The results of a prospective longitudinal controlled study comparing some metabolic effects of a low-dose levonorgestrel-ethinyl oestradiol combined oral contraceptive (Microgynon 30), a desogestrel-ethinyl oestradiol-containing pill (Marvelon) and a levonorgestrel-ethinyl oestradiol triphasic preparation (Triquilar) after one year of treatment in ethnic Chinese women are presented. Serum cholesterol levels are similar for the three pills at 6 and 12 months of treatment. Marvelon and Triquilar users showed rises in triglyceride levels while Microgynon 30 users had no change after one year of treatment. Lipoprotein fractions showed favourable changes in Triquilar and Marvelon users with significant rise in HDL fractions at 6 and 12 months; Microgynon 30 users had equivocal changes in HDL fractions. Carbohydrate metabolism as reflected by glucose tolerance showed deterioration with all 3 pills, being least with Microgynon 30 and greatest with Marvelon at 12 months. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/2521321/Comparative_metabolic_effects_of_three_types_of_combined_oral_contraceptive_pills_in_Chinese_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(89)90013-9 DB - PRIME DP - Unbound Medicine ER -