Tags

Type your tag names separated by a space and hit enter

Oral lichenoid lesions and serum antinuclear antibodies in Thai patients.
J Oral Pathol Med. 2015 Jul; 44(6):468-74.JO

Abstract

OBJECTIVES

The aim of this study was to investigate the presence of serum antinuclear antibodies (ANA) in Thai oral lichenoid drug reaction (OLDR) and oral lichen planus (OLP) patients.

MATERIALS AND METHODS

This study comprised 20 patients diagnosed with OLDR, 23 patients with OLP, and 24 healthy control subjects. Participants' blood samples were assayed for ANA staining patterns and serum ANA titer levels by immunofluorescence using human epithelial type 2 (HEp-2) as a substrate. The serum ANA titer levels were defined as low (1:40-1:80), medium (1:160-1:320), and high (>1:640).

RESULTS

Serum ANA were detected in 73.9%, 70%, and 25% of OLP, OLDR, and control subjects, respectively. There was a statistically significant difference between the number of serum-ANA-positive subjects in the OLP or OLDR groups and the control group (P < 0.01), but no significant difference between the OLP and OLDR groups. The speckled pattern was the most commonly found staining pattern, present in 60.9%, 55.0%, and 20.8% of the OLP, OLDR, and control subjects, respectively. The number of subjects with low ANA titers in the OLP and OLDR groups was significantly higher than that of the control group (P < 0.01). Medium ANA titers were found in 15%, 4.4%, and 4.2% of the OLDR, OLP, and control subjects, respectively, while high ANA titers were not found in any group.

CONCLUSIONS

The number of serum-ANA-positive OLP and OLDR patients was significantly higher than the control group. Speckled pattern and low titer levels were the most common findings in both OLP and OLDR groups.

Authors+Show Affiliations

Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25213373

Citation

Prucktrakul, Chalakorn, et al. "Oral Lichenoid Lesions and Serum Antinuclear Antibodies in Thai Patients." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 44, no. 6, 2015, pp. 468-74.
Prucktrakul C, Youngnak-Piboonratanakit P, Kanjanabuch P, et al. Oral lichenoid lesions and serum antinuclear antibodies in Thai patients. J Oral Pathol Med. 2015;44(6):468-74.
Prucktrakul, C., Youngnak-Piboonratanakit, P., Kanjanabuch, P., Prueksrisakul, T., & Thongprasom, K. (2015). Oral lichenoid lesions and serum antinuclear antibodies in Thai patients. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(6), 468-74. https://doi.org/10.1111/jop.12257
Prucktrakul C, et al. Oral Lichenoid Lesions and Serum Antinuclear Antibodies in Thai Patients. J Oral Pathol Med. 2015;44(6):468-74. PubMed PMID: 25213373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral lichenoid lesions and serum antinuclear antibodies in Thai patients. AU - Prucktrakul,Chalakorn, AU - Youngnak-Piboonratanakit,Pornpan, AU - Kanjanabuch,Patnarin, AU - Prueksrisakul,Titipong, AU - Thongprasom,Kobkan, Y1 - 2014/09/12/ PY - 2014/07/27/accepted PY - 2014/9/13/entrez PY - 2014/9/13/pubmed PY - 2016/8/16/medline KW - Thai KW - antinuclear antibodies KW - oral lichen planus KW - oral lichenoid drug reaction SP - 468 EP - 74 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 44 IS - 6 N2 - OBJECTIVES: The aim of this study was to investigate the presence of serum antinuclear antibodies (ANA) in Thai oral lichenoid drug reaction (OLDR) and oral lichen planus (OLP) patients. MATERIALS AND METHODS: This study comprised 20 patients diagnosed with OLDR, 23 patients with OLP, and 24 healthy control subjects. Participants' blood samples were assayed for ANA staining patterns and serum ANA titer levels by immunofluorescence using human epithelial type 2 (HEp-2) as a substrate. The serum ANA titer levels were defined as low (1:40-1:80), medium (1:160-1:320), and high (>1:640). RESULTS: Serum ANA were detected in 73.9%, 70%, and 25% of OLP, OLDR, and control subjects, respectively. There was a statistically significant difference between the number of serum-ANA-positive subjects in the OLP or OLDR groups and the control group (P < 0.01), but no significant difference between the OLP and OLDR groups. The speckled pattern was the most commonly found staining pattern, present in 60.9%, 55.0%, and 20.8% of the OLP, OLDR, and control subjects, respectively. The number of subjects with low ANA titers in the OLP and OLDR groups was significantly higher than that of the control group (P < 0.01). Medium ANA titers were found in 15%, 4.4%, and 4.2% of the OLDR, OLP, and control subjects, respectively, while high ANA titers were not found in any group. CONCLUSIONS: The number of serum-ANA-positive OLP and OLDR patients was significantly higher than the control group. Speckled pattern and low titer levels were the most common findings in both OLP and OLDR groups. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/25213373/Oral_lichenoid_lesions_and_serum_antinuclear_antibodies_in_Thai_patients_ L2 - https://doi.org/10.1111/jop.12257 DB - PRIME DP - Unbound Medicine ER -