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Oxidation of microcystin-LR by ferrate(VI): kinetics, degradation pathways, and toxicity assessments.
Environ Sci Technol. 2014 Oct 21; 48(20):12164-72.ES

Abstract

The presence of the potent cyanotoxin, microcystin-LR (MC-LR), in drinking water sources poses a serious risk to public health. The kinetics of the reactivity of ferrate(VI) (Fe(VI)O4(2-), Fe(VI)) with MC-LR and model compounds (sorbic acid, sorbic alcohol, and glycine anhydride) are reported over a range of solution pH. The degradation of MC-LR followed second-order kinetics with the bimolecular rate constant (kMCLR+Fe(VI)) decreasing from 1.3 ± 0.1 × 10(2) M(-1) s(-1) at pH 7.5 to 8.1 ± 0.08 M(-1) s(-1) at pH 10.0. The specific rate constants for the individual ferrate species were determined and compared with a number of common chemical oxidants employed for water treatment. Detailed product studies using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) indicated the oxidized products (OPs) were primarily the result of hydroxylation of the aromatic ring, double bond of the methyldehydroalanine (Mdha) amino acid residue, and diene functionality. Products studies also indicate fragmentation of the cyclic MC-LR structure occurs under the reaction conditions. The analysis of protein phosphatase (PP1) activity suggested that the degradation byproducts of MC-LR did not possess significant biological toxicity. Fe(VI) was effective for the degradation MC-LR in water containing carbonate ions and fulvic acid (FA) and in lake water samples, but higher Fe(VI) dosages would be needed to completely remove MC-LR in lake water compared to deionized water.

Authors+Show Affiliations

Department of Chemistry and Biochemistry, Florida International University , 11200 SW Eighth Street, Miami, Florida 33199, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25215438

Citation

Jiang, Wenjun, et al. "Oxidation of microcystin-LR By ferrate(VI): Kinetics, Degradation Pathways, and Toxicity Assessments." Environmental Science & Technology, vol. 48, no. 20, 2014, pp. 12164-72.
Jiang W, Chen L, Batchu SR, et al. Oxidation of microcystin-LR by ferrate(VI): kinetics, degradation pathways, and toxicity assessments. Environ Sci Technol. 2014;48(20):12164-72.
Jiang, W., Chen, L., Batchu, S. R., Gardinali, P. R., Jasa, L., Marsalek, B., Zboril, R., Dionysiou, D. D., O'Shea, K. E., & Sharma, V. K. (2014). Oxidation of microcystin-LR by ferrate(VI): kinetics, degradation pathways, and toxicity assessments. Environmental Science & Technology, 48(20), 12164-72. https://doi.org/10.1021/es5030355
Jiang W, et al. Oxidation of microcystin-LR By ferrate(VI): Kinetics, Degradation Pathways, and Toxicity Assessments. Environ Sci Technol. 2014 Oct 21;48(20):12164-72. PubMed PMID: 25215438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidation of microcystin-LR by ferrate(VI): kinetics, degradation pathways, and toxicity assessments. AU - Jiang,Wenjun, AU - Chen,Long, AU - Batchu,Sudha Rani, AU - Gardinali,Piero R, AU - Jasa,Libor, AU - Marsalek,Blahoslav, AU - Zboril,Radek, AU - Dionysiou,Dionysios D, AU - O'Shea,Kevin E, AU - Sharma,Virender K, Y1 - 2014/10/02/ PY - 2014/9/13/entrez PY - 2014/9/13/pubmed PY - 2015/12/30/medline SP - 12164 EP - 72 JF - Environmental science & technology JO - Environ Sci Technol VL - 48 IS - 20 N2 - The presence of the potent cyanotoxin, microcystin-LR (MC-LR), in drinking water sources poses a serious risk to public health. The kinetics of the reactivity of ferrate(VI) (Fe(VI)O4(2-), Fe(VI)) with MC-LR and model compounds (sorbic acid, sorbic alcohol, and glycine anhydride) are reported over a range of solution pH. The degradation of MC-LR followed second-order kinetics with the bimolecular rate constant (kMCLR+Fe(VI)) decreasing from 1.3 ± 0.1 × 10(2) M(-1) s(-1) at pH 7.5 to 8.1 ± 0.08 M(-1) s(-1) at pH 10.0. The specific rate constants for the individual ferrate species were determined and compared with a number of common chemical oxidants employed for water treatment. Detailed product studies using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) indicated the oxidized products (OPs) were primarily the result of hydroxylation of the aromatic ring, double bond of the methyldehydroalanine (Mdha) amino acid residue, and diene functionality. Products studies also indicate fragmentation of the cyclic MC-LR structure occurs under the reaction conditions. The analysis of protein phosphatase (PP1) activity suggested that the degradation byproducts of MC-LR did not possess significant biological toxicity. Fe(VI) was effective for the degradation MC-LR in water containing carbonate ions and fulvic acid (FA) and in lake water samples, but higher Fe(VI) dosages would be needed to completely remove MC-LR in lake water compared to deionized water. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/25215438/Oxidation_of_microcystin_LR_by_ferrate_VI_:_kinetics_degradation_pathways_and_toxicity_assessments_ L2 - https://doi.org/10.1021/es5030355 DB - PRIME DP - Unbound Medicine ER -