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Serum 25-hydroxyvitamin d concentration and risk of dementia.
Epidemiology. 2014 Nov; 25(6):799-804.E

Abstract

BACKGROUND

High vitamin D status has been hypothesized to protect against dementia. The aim of the current study was to investigate whether serum 25-hydroxyvitamin D (25(OH)D) level predicts dementia risk.

METHODS

The study was based on the Mini-Finland Health Survey. The study population consisted of 5010 men and women, aged 40-79 years, and free of dementia at baseline. During a 17-year follow up, 151 incident cases of dementia (International Classification of Diseases, revision 8, code 290) occurred, according to population registers. Serum 25(OH)D concentration was determined from serum samples frozen at -20 °C and stored at baseline.

RESULTS

Among women, these with higher serum 25(OH)D concentrations showed a reduced risk of dementia. The hazard ratio between the highest and lowest quartiles of serum 25(OH)D was 0.33 (95% confidence interval = 0.15-0.73) in women and 0.74 (0.29-1.88) in men, after adjustment for age, month of blood draw, education, marital status, physical activity, smoking, alcohol consumption, body mass index, blood pressure, plasma fasting glucose, serum triglycerides, and serum total cholesterol.

CONCLUSIONS

The results are in line with the hypothesis that low vitamin D status may be a risk factor for dementia.

Authors+Show Affiliations

From the aNational Institute for Health and Welfare, Helsinki, Finland; and bUniversity of Eastern Finland, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25215530

Citation

Knekt, Paul, et al. "Serum 25-hydroxyvitamin D Concentration and Risk of Dementia." Epidemiology (Cambridge, Mass.), vol. 25, no. 6, 2014, pp. 799-804.
Knekt P, Sääksjärvi K, Järvinen R, et al. Serum 25-hydroxyvitamin d concentration and risk of dementia. Epidemiology. 2014;25(6):799-804.
Knekt, P., Sääksjärvi, K., Järvinen, R., Marniemi, J., Männistö, S., Kanerva, N., & Heliövaara, M. (2014). Serum 25-hydroxyvitamin d concentration and risk of dementia. Epidemiology (Cambridge, Mass.), 25(6), 799-804. https://doi.org/10.1097/EDE.0000000000000175
Knekt P, et al. Serum 25-hydroxyvitamin D Concentration and Risk of Dementia. Epidemiology. 2014;25(6):799-804. PubMed PMID: 25215530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin d concentration and risk of dementia. AU - Knekt,Paul, AU - Sääksjärvi,Katri, AU - Järvinen,Ritva, AU - Marniemi,Jukka, AU - Männistö,Satu, AU - Kanerva,Noora, AU - Heliövaara,Markku, PY - 2014/9/13/entrez PY - 2014/9/13/pubmed PY - 2015/6/3/medline SP - 799 EP - 804 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 25 IS - 6 N2 - BACKGROUND: High vitamin D status has been hypothesized to protect against dementia. The aim of the current study was to investigate whether serum 25-hydroxyvitamin D (25(OH)D) level predicts dementia risk. METHODS: The study was based on the Mini-Finland Health Survey. The study population consisted of 5010 men and women, aged 40-79 years, and free of dementia at baseline. During a 17-year follow up, 151 incident cases of dementia (International Classification of Diseases, revision 8, code 290) occurred, according to population registers. Serum 25(OH)D concentration was determined from serum samples frozen at -20 °C and stored at baseline. RESULTS: Among women, these with higher serum 25(OH)D concentrations showed a reduced risk of dementia. The hazard ratio between the highest and lowest quartiles of serum 25(OH)D was 0.33 (95% confidence interval = 0.15-0.73) in women and 0.74 (0.29-1.88) in men, after adjustment for age, month of blood draw, education, marital status, physical activity, smoking, alcohol consumption, body mass index, blood pressure, plasma fasting glucose, serum triglycerides, and serum total cholesterol. CONCLUSIONS: The results are in line with the hypothesis that low vitamin D status may be a risk factor for dementia. SN - 1531-5487 UR - https://www.unboundmedicine.com/medline/citation/25215530/Serum_25_hydroxyvitamin_d_concentration_and_risk_of_dementia_ L2 - https://doi.org/10.1097/EDE.0000000000000175 DB - PRIME DP - Unbound Medicine ER -