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Benefits of foods supplemented with vegetable oils rich in α-linolenic, stearidonic or docosahexaenoic acid in hypertriglyceridemic subjects: a double-blind, randomized, controlled trail.
Eur J Nutr. 2015 Sep; 54(6):881-93.EJ

Abstract

PURPOSE

The aim of the study was to investigate the influence of foods enriched with vegetable oils varying in their n-3 polyunsaturated fatty acids profile on cardiovascular risk factors for hypertriglyceridemic subjects.

METHODS

Fifty-nine hypertriglyceridemic subjects (triglycerides ≥ 1.5 mmol/L) were included in the randomized, double-blind, placebo-controlled, crossover study. The placebo group received sunflower oil [linoleic acid (LA) group; 10 g LA/day]. The intervention groups received linseed oil [α-linolenic acid (ALA) group; 7 g ALA/day], echium oil [stearidonic acid (SDA) group; 2 g SDA/day] or microalgae oil [docosahexaenoic acid (DHA) group; 2 g DHA/day] over 10 weeks. Blood samples were collected at baseline and at the end of each period.

RESULTS

Total cholesterol (TC) and low-density-lipoprotein cholesterol decreased significantly in the LA and ALA groups (LA: P ≤ 0.01, ALA: P ≤ 0.05). No changes in blood lipids were observed in the SDA group. Significant increases in TC and high-density-lipoprotein cholesterol occurred in the DHA group (P ≤ 0.05). In the ALA and SDA groups, the content of eicosapentaenoic acid in erythrocyte lipids increased significantly (P ≤ 0.05) after 10 weeks (ALA group: 38 ± 37 %, SDA group: 73 ± 59 %).

CONCLUSION

Foods enriched with different vegetable oils rich in ALA or SDA are able to increase the n-3 long-chain polyunsaturated fatty acids content in erythrocyte lipids; echium oil is more potent in comparison with linseed oil. Blood lipids were beneficially modified through the consumption of food products enriched with sunflower, linseed and microalgae oils, whereas echium oil did not affect blood lipids. ClinicalTrials.gov: NCT01437930.

Authors+Show Affiliations

Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str. 24, 07743, Jena, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25216712

Citation

Dittrich, Manja, et al. "Benefits of Foods Supplemented With Vegetable Oils Rich in Α-linolenic, Stearidonic or Docosahexaenoic Acid in Hypertriglyceridemic Subjects: a Double-blind, Randomized, Controlled Trail." European Journal of Nutrition, vol. 54, no. 6, 2015, pp. 881-93.
Dittrich M, Jahreis G, Bothor K, et al. Benefits of foods supplemented with vegetable oils rich in α-linolenic, stearidonic or docosahexaenoic acid in hypertriglyceridemic subjects: a double-blind, randomized, controlled trail. Eur J Nutr. 2015;54(6):881-93.
Dittrich, M., Jahreis, G., Bothor, K., Drechsel, C., Kiehntopf, M., Blüher, M., & Dawczynski, C. (2015). Benefits of foods supplemented with vegetable oils rich in α-linolenic, stearidonic or docosahexaenoic acid in hypertriglyceridemic subjects: a double-blind, randomized, controlled trail. European Journal of Nutrition, 54(6), 881-93. https://doi.org/10.1007/s00394-014-0764-2
Dittrich M, et al. Benefits of Foods Supplemented With Vegetable Oils Rich in Α-linolenic, Stearidonic or Docosahexaenoic Acid in Hypertriglyceridemic Subjects: a Double-blind, Randomized, Controlled Trail. Eur J Nutr. 2015;54(6):881-93. PubMed PMID: 25216712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefits of foods supplemented with vegetable oils rich in α-linolenic, stearidonic or docosahexaenoic acid in hypertriglyceridemic subjects: a double-blind, randomized, controlled trail. AU - Dittrich,Manja, AU - Jahreis,Gerhard, AU - Bothor,Kristin, AU - Drechsel,Carina, AU - Kiehntopf,Michael, AU - Blüher,Matthias, AU - Dawczynski,Christine, Y1 - 2014/09/13/ PY - 2014/03/03/received PY - 2014/08/26/accepted PY - 2014/9/14/entrez PY - 2014/9/14/pubmed PY - 2016/5/19/medline SP - 881 EP - 93 JF - European journal of nutrition JO - Eur J Nutr VL - 54 IS - 6 N2 - PURPOSE: The aim of the study was to investigate the influence of foods enriched with vegetable oils varying in their n-3 polyunsaturated fatty acids profile on cardiovascular risk factors for hypertriglyceridemic subjects. METHODS: Fifty-nine hypertriglyceridemic subjects (triglycerides ≥ 1.5 mmol/L) were included in the randomized, double-blind, placebo-controlled, crossover study. The placebo group received sunflower oil [linoleic acid (LA) group; 10 g LA/day]. The intervention groups received linseed oil [α-linolenic acid (ALA) group; 7 g ALA/day], echium oil [stearidonic acid (SDA) group; 2 g SDA/day] or microalgae oil [docosahexaenoic acid (DHA) group; 2 g DHA/day] over 10 weeks. Blood samples were collected at baseline and at the end of each period. RESULTS: Total cholesterol (TC) and low-density-lipoprotein cholesterol decreased significantly in the LA and ALA groups (LA: P ≤ 0.01, ALA: P ≤ 0.05). No changes in blood lipids were observed in the SDA group. Significant increases in TC and high-density-lipoprotein cholesterol occurred in the DHA group (P ≤ 0.05). In the ALA and SDA groups, the content of eicosapentaenoic acid in erythrocyte lipids increased significantly (P ≤ 0.05) after 10 weeks (ALA group: 38 ± 37 %, SDA group: 73 ± 59 %). CONCLUSION: Foods enriched with different vegetable oils rich in ALA or SDA are able to increase the n-3 long-chain polyunsaturated fatty acids content in erythrocyte lipids; echium oil is more potent in comparison with linseed oil. Blood lipids were beneficially modified through the consumption of food products enriched with sunflower, linseed and microalgae oils, whereas echium oil did not affect blood lipids. ClinicalTrials.gov: NCT01437930. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/25216712/Benefits_of_foods_supplemented_with_vegetable_oils_rich_in_α_linolenic_stearidonic_or_docosahexaenoic_acid_in_hypertriglyceridemic_subjects:_a_double_blind_randomized_controlled_trail_ DB - PRIME DP - Unbound Medicine ER -