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The -323P0/P10 factor VII gene polymorphism and the risk of recurrent miscarriage.
Ginekol Pol. 2014 Aug; 85(8):594-9.GP

Abstract

OBJECTIVES

Genetically determined disturbances in the activity of coagulation factor VII may lead to obstetric complications. The aim of the study was to evaluate the correlation between -323P0/P10 factor VII gene polymorphism and the risk of recurrent miscarriage.

MATERIAL AND METHODS

The study group consisted of 152 women with a history of > or = 2 miscarriages. The control group comprised 180 women with no history of miscarriage and > or = 1 pregnancy who gave birth to a healthy newborn at term. The study group was further subdivided twice into two subgroups: 1174 patients with a history of 2 miscarriages and 38 subjects with a history of > or = 3 miscarriages, and 123 patients with miscarriages < 13 gw. and 29 with miscarriages < 21 gw. Genetic analysis was performed with the use of PCR/RFLP.

RESULTS

Overrepresentation of P0/P0 genotype and lower frequency of P0/P10 genotype was noted in the study group as compared to controls (P0/P0: 80.26 vs. 76.67%, p = 0.25; P0/P10: 18.42 vs. 22.78%, p = 0.20). A higher presentation of P0/P0 genotype and P0 allele, lower frequency of P0/P10 genotype and P10 allele was observed in the subgroup of women with > or = 3 miscarriages as compared to controls (P0/P0: 8.84 vs. 76.67%, p = 0.12; P0: 93.42 vs. 88.06%, p = 0.12; P0/P10:13.16 vs. 22.78%, p = 0.13; P10: 11.94 vs. 6.58%, p = 0.12).

CONCLUSIONS

The obtained results suggest a probable protective role of -323P10 allele against the risk of miscarriage in women with > or = 3 recurrent pregnancy losses.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25219139

Citation

Barlik, Magdalena, et al. "The -323P0/P10 Factor VII Gene Polymorphism and the Risk of Recurrent Miscarriage." Ginekologia Polska, vol. 85, no. 8, 2014, pp. 594-9.
Barlik M, Seremak-Mrozikiewicz A, Wolski H, et al. The -323P0/P10 factor VII gene polymorphism and the risk of recurrent miscarriage. Ginekol Pol. 2014;85(8):594-9.
Barlik, M., Seremak-Mrozikiewicz, A., Wolski, H., Bogacz, A., Mrozikiewicz, P. M., Czerny, B., & Drews, K. (2014). The -323P0/P10 factor VII gene polymorphism and the risk of recurrent miscarriage. Ginekologia Polska, 85(8), 594-9.
Barlik M, et al. The -323P0/P10 Factor VII Gene Polymorphism and the Risk of Recurrent Miscarriage. Ginekol Pol. 2014;85(8):594-9. PubMed PMID: 25219139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The -323P0/P10 factor VII gene polymorphism and the risk of recurrent miscarriage. AU - Barlik,Magdalena, AU - Seremak-Mrozikiewicz,Agnieszka, AU - Wolski,Hubert, AU - Bogacz,Anna, AU - Mrozikiewicz,Przemysław M, AU - Czerny,Bogusław, AU - Drews,Krzysztof, PY - 2014/9/16/entrez PY - 2014/9/16/pubmed PY - 2014/10/1/medline SP - 594 EP - 9 JF - Ginekologia polska JO - Ginekol Pol VL - 85 IS - 8 N2 - OBJECTIVES: Genetically determined disturbances in the activity of coagulation factor VII may lead to obstetric complications. The aim of the study was to evaluate the correlation between -323P0/P10 factor VII gene polymorphism and the risk of recurrent miscarriage. MATERIAL AND METHODS: The study group consisted of 152 women with a history of > or = 2 miscarriages. The control group comprised 180 women with no history of miscarriage and > or = 1 pregnancy who gave birth to a healthy newborn at term. The study group was further subdivided twice into two subgroups: 1174 patients with a history of 2 miscarriages and 38 subjects with a history of > or = 3 miscarriages, and 123 patients with miscarriages < 13 gw. and 29 with miscarriages < 21 gw. Genetic analysis was performed with the use of PCR/RFLP. RESULTS: Overrepresentation of P0/P0 genotype and lower frequency of P0/P10 genotype was noted in the study group as compared to controls (P0/P0: 80.26 vs. 76.67%, p = 0.25; P0/P10: 18.42 vs. 22.78%, p = 0.20). A higher presentation of P0/P0 genotype and P0 allele, lower frequency of P0/P10 genotype and P10 allele was observed in the subgroup of women with > or = 3 miscarriages as compared to controls (P0/P0: 8.84 vs. 76.67%, p = 0.12; P0: 93.42 vs. 88.06%, p = 0.12; P0/P10:13.16 vs. 22.78%, p = 0.13; P10: 11.94 vs. 6.58%, p = 0.12). CONCLUSIONS: The obtained results suggest a probable protective role of -323P10 allele against the risk of miscarriage in women with > or = 3 recurrent pregnancy losses. SN - 0017-0011 UR - https://www.unboundmedicine.com/medline/citation/25219139/The__323P0/P10_factor_VII_gene_polymorphism_and_the_risk_of_recurrent_miscarriage_ L2 - http://www.diseaseinfosearch.org/result/9210 DB - PRIME DP - Unbound Medicine ER -