Tags

Type your tag names separated by a space and hit enter

Adenomyomas of the uterine cervix: report of a cohort including endocervical and novel variants [corrected].
Histopathology. 2015 Feb; 66(3):420-9.H

Abstract

AIMS

To report a series of 10 cervical adenomyomas of endocervical type and the first case of a mesonephric adenomyoma.

METHODS AND RESULTS

The patients' ages ranged from 30 to 55 years. Most lesions were grossly polypoid; a minority were intramural or exophytic. In six of seven endocervical adenomyomas received in consultation, adenoma malignum was considered. A variety of benign lesions, including lobular endocervical glandular hyperplasia (LEGH), adenofibroma, endocervicosis and tunnel clusters, were also considered. The endocervical adenomyomas consisted of bland mucinous glands, sometimes with focal epithelial metaplasia, within a prominent smooth muscle stroma. There was usually a focal lobular architecture and sometimes papillary infoldings. A characteristic feature was a rim of stroma surrounding glands, surrounded in turn by smooth muscle. Previously undescribed features were 'symplastic-like' smooth muscle, stromal adipose tissue, gland rupture with mucin extravasation, prominent adenofibroma-like areas and surface cervical intraepithelial neoplasia (CIN). Diffuse oestrogen receptor (ER) immunoreactivity was useful in excluding adenoma malignum and LEGH, which are hormone receptor-negative. The mesonephric adenomyoma consisted of a lobular arrangement of mesonephric glands [ER/progesterone receptor (PR)-negative; vimentin and luminal CD10 immunoreactivity] within a smooth muscle stroma.

CONCLUSIONS

Endocervical and mesonephric adenomyomas are rare lesions which are often misdiagnosed, possibly because of lack of familiarity among pathologists.

Authors+Show Affiliations

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25219586

Citation

Casey, Shauna, and W Glenn McCluggage. "Adenomyomas of the Uterine Cervix: Report of a Cohort Including Endocervical and Novel Variants [corrected]." Histopathology, vol. 66, no. 3, 2015, pp. 420-9.
Casey S, McCluggage WG. Adenomyomas of the uterine cervix: report of a cohort including endocervical and novel variants [corrected]. Histopathology. 2015;66(3):420-9.
Casey, S., & McCluggage, W. G. (2015). Adenomyomas of the uterine cervix: report of a cohort including endocervical and novel variants [corrected]. Histopathology, 66(3), 420-9. https://doi.org/10.1111/his.12546
Casey S, McCluggage WG. Adenomyomas of the Uterine Cervix: Report of a Cohort Including Endocervical and Novel Variants [corrected]. Histopathology. 2015;66(3):420-9. PubMed PMID: 25219586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adenomyomas of the uterine cervix: report of a cohort including endocervical and novel variants [corrected]. AU - Casey,Shauna, AU - McCluggage,W Glenn, Y1 - 2014/11/28/ PY - 2014/07/31/received PY - 2014/09/10/accepted PY - 2014/9/16/entrez PY - 2014/9/16/pubmed PY - 2015/9/15/medline KW - adenomyoma KW - cervix KW - differential diagnosis SP - 420 EP - 9 JF - Histopathology JO - Histopathology VL - 66 IS - 3 N2 - AIMS: To report a series of 10 cervical adenomyomas of endocervical type and the first case of a mesonephric adenomyoma. METHODS AND RESULTS: The patients' ages ranged from 30 to 55 years. Most lesions were grossly polypoid; a minority were intramural or exophytic. In six of seven endocervical adenomyomas received in consultation, adenoma malignum was considered. A variety of benign lesions, including lobular endocervical glandular hyperplasia (LEGH), adenofibroma, endocervicosis and tunnel clusters, were also considered. The endocervical adenomyomas consisted of bland mucinous glands, sometimes with focal epithelial metaplasia, within a prominent smooth muscle stroma. There was usually a focal lobular architecture and sometimes papillary infoldings. A characteristic feature was a rim of stroma surrounding glands, surrounded in turn by smooth muscle. Previously undescribed features were 'symplastic-like' smooth muscle, stromal adipose tissue, gland rupture with mucin extravasation, prominent adenofibroma-like areas and surface cervical intraepithelial neoplasia (CIN). Diffuse oestrogen receptor (ER) immunoreactivity was useful in excluding adenoma malignum and LEGH, which are hormone receptor-negative. The mesonephric adenomyoma consisted of a lobular arrangement of mesonephric glands [ER/progesterone receptor (PR)-negative; vimentin and luminal CD10 immunoreactivity] within a smooth muscle stroma. CONCLUSIONS: Endocervical and mesonephric adenomyomas are rare lesions which are often misdiagnosed, possibly because of lack of familiarity among pathologists. SN - 1365-2559 UR - https://www.unboundmedicine.com/medline/citation/25219586/Adenomyomas_of_the_uterine_cervix:_report_of_a_cohort_including_endocervical_and_novel_variants_[corrected]_ L2 - https://doi.org/10.1111/his.12546 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.