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Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study.
Int J Cancer 2015; 136(5):E396-409IJ

Abstract

There is limited prospective data on the relationship between consumption of vegetables and fruits and the risk of head-neck cancer (HNC) subtypes [i.e., oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC) and laryngeal cancer (LC)]. Therefore, we investigated these associations within the Netherlands Cohort Study, in which 120,852 participants completed a 150-item food frequency questionnaire at baseline in 1986. After 20.3 years of follow-up, 415 cases of HNC (131 OCC, 88 OHPC, three oral cavity/pharynx unspecified or overlapping and 193 LC) and 3,898 subcohort members were available for case-cohort analysis using Cox proportional hazards models. Total vegetable and fruit consumption was inversely associated with risk of HNC overall [multivariable-adjusted rate ratios for highest vs. lowest quartile: 0.61, 95% confidence interval (CI) 0.44-0.85, p trend 0.002] and all HNC subtypes, with the strongest associations for OCC. Total vegetable intake and total fruit intake were also associated with a decreased risk of HNC overall and HNC subtypes. No significant interaction was found between vegetable and fruit intake and alcohol consumption or cigarette smoking. In conclusion, in this large-scale cohort study, consumption of vegetables and fruits was associated with a decreased risk of HNC overall and all subtypes. Consumption of vegetables and fruits (or of specific groups of them) may protect against HNC and its subtypes.

Authors+Show Affiliations

Department of Epidemiology, GROW - School for Oncology & Developmental Biology, Maastricht University, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25220255

Citation

Maasland, Denise H E., et al. "Consumption of Vegetables and Fruits and Risk of Subtypes of Head-neck Cancer in the Netherlands Cohort Study." International Journal of Cancer, vol. 136, no. 5, 2015, pp. E396-409.
Maasland DH, van den Brandt PA, Kremer B, et al. Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study. Int J Cancer. 2015;136(5):E396-409.
Maasland, D. H., van den Brandt, P. A., Kremer, B., Goldbohm, R. A., & Schouten, L. J. (2015). Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study. International Journal of Cancer, 136(5), pp. E396-409. doi:10.1002/ijc.29219.
Maasland DH, et al. Consumption of Vegetables and Fruits and Risk of Subtypes of Head-neck Cancer in the Netherlands Cohort Study. Int J Cancer. 2015 Mar 1;136(5):E396-409. PubMed PMID: 25220255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study. AU - Maasland,Denise H E, AU - van den Brandt,Piet A, AU - Kremer,Bernd, AU - Goldbohm,R Alexandra, AU - Schouten,Leo J, Y1 - 2014/10/08/ PY - 2013/12/23/received PY - 2014/07/18/revised PY - 2014/08/11/accepted PY - 2014/9/16/entrez PY - 2014/9/16/pubmed PY - 2015/2/27/medline KW - cohort studies KW - etiology KW - fruits KW - head-neck cancer KW - vegetables SP - E396 EP - 409 JF - International journal of cancer JO - Int. J. Cancer VL - 136 IS - 5 N2 - There is limited prospective data on the relationship between consumption of vegetables and fruits and the risk of head-neck cancer (HNC) subtypes [i.e., oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC) and laryngeal cancer (LC)]. Therefore, we investigated these associations within the Netherlands Cohort Study, in which 120,852 participants completed a 150-item food frequency questionnaire at baseline in 1986. After 20.3 years of follow-up, 415 cases of HNC (131 OCC, 88 OHPC, three oral cavity/pharynx unspecified or overlapping and 193 LC) and 3,898 subcohort members were available for case-cohort analysis using Cox proportional hazards models. Total vegetable and fruit consumption was inversely associated with risk of HNC overall [multivariable-adjusted rate ratios for highest vs. lowest quartile: 0.61, 95% confidence interval (CI) 0.44-0.85, p trend 0.002] and all HNC subtypes, with the strongest associations for OCC. Total vegetable intake and total fruit intake were also associated with a decreased risk of HNC overall and HNC subtypes. No significant interaction was found between vegetable and fruit intake and alcohol consumption or cigarette smoking. In conclusion, in this large-scale cohort study, consumption of vegetables and fruits was associated with a decreased risk of HNC overall and all subtypes. Consumption of vegetables and fruits (or of specific groups of them) may protect against HNC and its subtypes. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/25220255/Consumption_of_vegetables_and_fruits_and_risk_of_subtypes_of_head_neck_cancer_in_the_Netherlands_Cohort_Study_ L2 - https://doi.org/10.1002/ijc.29219 DB - PRIME DP - Unbound Medicine ER -